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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9AS8

Global reconstruction of 5-HT2AR bound to psilocin in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001587molecular_functionGq/11-coupled serotonin receptor activity
A0001618molecular_functionvirus receptor activity
A0001659biological_processtemperature homeostasis
A0002720biological_processpositive regulation of cytokine production involved in immune response
A0004930molecular_functionG protein-coupled receptor activity
A0004993molecular_functionG protein-coupled serotonin receptor activity
A0005515molecular_functionprotein binding
A0005883cellular_componentneurofilament
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0006096biological_processglycolytic process
A0006874biological_processintracellular calcium ion homeostasis
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007208biological_processphospholipase C-activating serotonin receptor signaling pathway
A0007210biological_processserotonin receptor signaling pathway
A0007268biological_processchemical synaptic transmission
A0007613biological_processmemory
A0008284biological_processpositive regulation of cell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0010513biological_processpositive regulation of phosphatidylinositol biosynthetic process
A0014059biological_processregulation of dopamine secretion
A0014824biological_processartery smooth muscle contraction
A0014832biological_processurinary bladder smooth muscle contraction
A0016020cellular_componentmembrane
A0030296molecular_functionprotein tyrosine kinase activator activity
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030594molecular_functionneurotransmitter receptor activity
A0031410cellular_componentcytoplasmic vesicle
A0031652biological_processpositive regulation of heat generation
A0042220biological_processresponse to cocaine
A0042734cellular_componentpresynaptic membrane
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043025cellular_componentneuronal cell body
A0043198cellular_componentdendritic shaft
A0043267biological_processnegative regulation of potassium ion transport
A0043525biological_processpositive regulation of neuron apoptotic process
A0044380biological_processprotein localization to cytoskeleton
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0045600biological_processpositive regulation of fat cell differentiation
A0045821biological_processpositive regulation of glycolytic process
A0045907biological_processpositive regulation of vasoconstriction
A0046718biological_processsymbiont entry into host cell
A0046960biological_processsensitization
A0048148biological_processbehavioral response to cocaine
A0050729biological_processpositive regulation of inflammatory response
A0050951biological_processsensory perception of temperature stimulus
A0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
A0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051378molecular_functionserotonin binding
A0051967biological_processnegative regulation of synaptic transmission, glutamatergic
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070852cellular_componentcell body fiber
A0071886molecular_function1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
A0098664biological_processG protein-coupled serotonin receptor signaling pathway
A0098666cellular_componentG protein-coupled serotonin receptor complex
A0098793cellular_componentpresynapse
A0098978cellular_componentglutamatergic synapse
A0099171biological_processpresynaptic modulation of chemical synaptic transmission
A0099589molecular_functionserotonin receptor activity
A1900119biological_processpositive regulation of execution phase of apoptosis
A1901731biological_processpositive regulation of platelet aggregation
A2000573biological_processpositive regulation of DNA biosynthetic process
C0001750cellular_componentphotoreceptor outer segment
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
C0007265biological_processRas protein signal transduction
C0008283biological_processcell population proliferation
C0016020cellular_componentmembrane
C0030159molecular_functionsignaling receptor complex adaptor activity
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0050909biological_processsensory perception of taste
C0051020molecular_functionGTPase binding
C0060041biological_processretina development in camera-type eye
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
C0097381cellular_componentphotoreceptor disc membrane
C1903561cellular_componentextracellular vesicle
D0005515molecular_functionprotein binding
D0005834cellular_componentheterotrimeric G-protein complex
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
D0016020cellular_componentmembrane
D0031681molecular_functionG-protein beta-subunit binding
D0045202cellular_componentsynapse
D0048144biological_processfibroblast proliferation
D0070062cellular_componentextracellular exosome
D0071380biological_processcellular response to prostaglandin E stimulus
D0071870biological_processcellular response to catecholamine stimulus
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASImHLCAISLDRYVaI
ChainResidueDetails
AALA161-ILE177
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
CLEU70-SER84
CILE157-ILE171
CLEU285-ALA299
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues32
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues24
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsMotif: {"description":"DRY motif; important for ligand-induced conformation changes","evidences":[{"source":"UniProtKB","id":"P41595","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsMotif: {"description":"NPxxY motif; important for ligand-induced conformation changes and signaling","evidences":[{"source":"UniProtKB","id":"P41595","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35084960","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WC4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35084960","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7WC4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsSite: {"description":"Hydrophobic barrier that decreases the speed of ligand binding and dissociation","evidences":[{"source":"PubMed","id":"28129538","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues48
DetailsRepeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues45
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues40
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues41
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues43
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues41
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues30
DetailsRepeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues1
DetailsModified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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