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9AS3

Local refinement of 5-HT2AR bound to LSD in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001587molecular_functionGq/11-coupled serotonin receptor activity
A0001618molecular_functionvirus receptor activity
A0001659biological_processtemperature homeostasis
A0002720biological_processpositive regulation of cytokine production involved in immune response
A0004930molecular_functionG protein-coupled receptor activity
A0004993molecular_functionG protein-coupled serotonin receptor activity
A0005515molecular_functionprotein binding
A0005883cellular_componentneurofilament
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0006096biological_processglycolytic process
A0006874biological_processintracellular calcium ion homeostasis
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007208biological_processphospholipase C-activating serotonin receptor signaling pathway
A0007210biological_processserotonin receptor signaling pathway
A0007268biological_processchemical synaptic transmission
A0007613biological_processmemory
A0008284biological_processpositive regulation of cell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0010513biological_processpositive regulation of phosphatidylinositol biosynthetic process
A0014059biological_processregulation of dopamine secretion
A0014824biological_processartery smooth muscle contraction
A0014832biological_processurinary bladder smooth muscle contraction
A0016020cellular_componentmembrane
A0030296molecular_functionprotein tyrosine kinase activator activity
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030594molecular_functionneurotransmitter receptor activity
A0031410cellular_componentcytoplasmic vesicle
A0031652biological_processpositive regulation of heat generation
A0042220biological_processresponse to cocaine
A0042734cellular_componentpresynaptic membrane
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043025cellular_componentneuronal cell body
A0043198cellular_componentdendritic shaft
A0043267biological_processnegative regulation of potassium ion transport
A0043525biological_processpositive regulation of neuron apoptotic process
A0044380biological_processprotein localization to cytoskeleton
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0045600biological_processpositive regulation of fat cell differentiation
A0045821biological_processpositive regulation of glycolytic process
A0045907biological_processpositive regulation of vasoconstriction
A0046718biological_processsymbiont entry into host cell
A0046960biological_processsensitization
A0048148biological_processbehavioral response to cocaine
A0050729biological_processpositive regulation of inflammatory response
A0050951biological_processsensory perception of temperature stimulus
A0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
A0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051378molecular_functionserotonin binding
A0051967biological_processnegative regulation of synaptic transmission, glutamatergic
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070852cellular_componentcell body fiber
A0071886molecular_function1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
A0098664biological_processG protein-coupled serotonin receptor signaling pathway
A0098666cellular_componentG protein-coupled serotonin receptor complex
A0098793cellular_componentpresynapse
A0098978cellular_componentglutamatergic synapse
A0099171biological_processpresynaptic modulation of chemical synaptic transmission
A0099589molecular_functionserotonin receptor activity
A1900119biological_processpositive regulation of execution phase of apoptosis
A1901731biological_processpositive regulation of platelet aggregation
A2000573biological_processpositive regulation of DNA biosynthetic process
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASImHLCAISLDRYVaI
ChainResidueDetails
AALA161-ILE177

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues110
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN
ChainResidueDetails
AMET1-LEU80
AGLY138-LYS146
AGLN216-ASP232
ACYS349-ASP356

site_idSWS_FT_FI2
Number of Residues16
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN
ChainResidueDetails
ATHR81-MET97

site_idSWS_FT_FI3
Number of Residues183
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN
ChainResidueDetails
AALA98-TYR111
AASP172-LYS191
ALYS259-CYS322
APHE383-VAL471

site_idSWS_FT_FI4
Number of Residues25
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN
ChainResidueDetails
APHE112-TYR137

site_idSWS_FT_FI5
Number of Residues24
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN
ChainResidueDetails
ALEU147-LEU171

site_idSWS_FT_FI6
Number of Residues23
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN
ChainResidueDetails
AALA192-LEU215

site_idSWS_FT_FI7
Number of Residues25
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN
ChainResidueDetails
AASN233-ILE258

site_idSWS_FT_FI8
Number of Residues25
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN
ChainResidueDetails
ALYS323-ILE348

site_idSWS_FT_FI9
Number of Residues25
DetailsTRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN
ChainResidueDetails
AVAL357-LEU382

site_idSWS_FT_FI10
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:35084960, ECO:0007744|PDB:7WC4
ChainResidueDetails
AASP155

site_idSWS_FT_FI11
Number of Residues1
DetailsBINDING: BINDING => ECO:0000305|PubMed:35084960, ECO:0007744|PDB:7WC4
ChainResidueDetails
AASN343

site_idSWS_FT_FI12
Number of Residues1
DetailsSITE: Hydrophobic barrier that decreases the speed of ligand binding and dissociation => ECO:0000269|PubMed:28129538
ChainResidueDetails
ALEU229

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:24637012
ChainResidueDetails
ASER280

site_idSWS_FT_FI14
Number of Residues5
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN8
AASN38
AASN44
AASN51
AASN54

237992

PDB entries from 2025-06-25

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