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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9ARX

Local refinement of 5-HT2AR bound to 5-HT in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001587molecular_functionGq/11-coupled serotonin receptor activity
A0001618molecular_functionvirus receptor activity
A0001659biological_processtemperature homeostasis
A0002720biological_processpositive regulation of cytokine production involved in immune response
A0004930molecular_functionG protein-coupled receptor activity
A0004993molecular_functionG protein-coupled serotonin receptor activity
A0005515molecular_functionprotein binding
A0005883cellular_componentneurofilament
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0006096biological_processglycolytic process
A0006874biological_processintracellular calcium ion homeostasis
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007208biological_processphospholipase C-activating serotonin receptor signaling pathway
A0007210biological_processserotonin receptor signaling pathway
A0007268biological_processchemical synaptic transmission
A0007613biological_processmemory
A0008284biological_processpositive regulation of cell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0010513biological_processpositive regulation of phosphatidylinositol biosynthetic process
A0014059biological_processregulation of dopamine secretion
A0014824biological_processartery smooth muscle contraction
A0014832biological_processurinary bladder smooth muscle contraction
A0030296molecular_functionprotein tyrosine kinase activator activity
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030594molecular_functionneurotransmitter receptor activity
A0031410cellular_componentcytoplasmic vesicle
A0031652biological_processpositive regulation of heat generation
A0042220biological_processresponse to cocaine
A0042734cellular_componentpresynaptic membrane
A0042802molecular_functionidentical protein binding
A0043025cellular_componentneuronal cell body
A0043198cellular_componentdendritic shaft
A0043267biological_processnegative regulation of potassium ion transport
A0043525biological_processpositive regulation of neuron apoptotic process
A0044380biological_processprotein localization to cytoskeleton
A0044877molecular_functionprotein-containing complex binding
A0045211cellular_componentpostsynaptic membrane
A0045600biological_processpositive regulation of fat cell differentiation
A0045821biological_processpositive regulation of glycolytic process
A0045907biological_processpositive regulation of vasoconstriction
A0046718biological_processsymbiont entry into host cell
A0046960biological_processsensitization
A0048148biological_processbehavioral response to cocaine
A0050729biological_processpositive regulation of inflammatory response
A0050951biological_processsensory perception of temperature stimulus
A0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
A0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051378molecular_functionserotonin binding
A0051967biological_processnegative regulation of synaptic transmission, glutamatergic
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070852cellular_componentcell body fiber
A0071886molecular_function1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
A0098664biological_processG protein-coupled serotonin receptor signaling pathway
A0098666cellular_componentG protein-coupled serotonin receptor complex
A0098793cellular_componentpresynapse
A0098978cellular_componentglutamatergic synapse
A0099171biological_processpresynaptic modulation of chemical synaptic transmission
A0099589molecular_functionserotonin receptor activity
A1900119biological_processpositive regulation of execution phase of apoptosis
A1901731biological_processpositive regulation of platelet aggregation
A2000573biological_processpositive regulation of DNA biosynthetic process
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASImHLCAISLDRYVaI
ChainResidueDetails
AALA161-ILE177
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues32
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues24
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"36171289","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsMotif: {"description":"DRY motif; important for ligand-induced conformation changes","evidences":[{"source":"UniProtKB","id":"P41595","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsMotif: {"description":"NPxxY motif; important for ligand-induced conformation changes and signaling","evidences":[{"source":"UniProtKB","id":"P41595","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35084960","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WC4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35084960","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7WC4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsSite: {"description":"Hydrophobic barrier that decreases the speed of ligand binding and dissociation","evidences":[{"source":"PubMed","id":"28129538","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

244693

PDB entries from 2025-11-12

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