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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

966C

CRYSTAL STRUCTURE OF FIBROBLAST COLLAGENASE-1 COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0031012	cellular_component	extracellular matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 265

Chain	Residue
A	RS21
A	HIS218
A	HIS222
A	HIS228
A	HOH297

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 266

Chain	Residue
A	HIS196
A	HIS168
A	ASP170
A	HIS183
A	PHE185

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 267

Chain	Residue
A	ASP175
A	GLY176
A	GLY178
A	ASN180
A	ASP198
A	GLU201

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 268

Chain	Residue
A	ASP158
A	GLY190
A	GLY192
A	ASP194
A	HOH310
A	HOH353

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 269

Chain	Residue
A	ASP124
A	GLU199
A	GLU201
A	HOH278
A	HOH279

site_id	AC6
Number of Residues	18
Details	BINDING SITE FOR RESIDUE RS2 A 1

Chain	Residue
A	ASN180
A	LEU181
A	ALA182
A	PHE207
A	ARG208
A	GLU209
A	HIS218
A	GLU219
A	HIS222
A	HIS228
A	LEU235
A	TYR237
A	SER239
A	TYR240
A	THR241
A	ZN265
A	HOH297
A	HOH336

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHELGHSL

Chain	Residue	Details
A	VAL215-LEU224

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE:

Chain	Residue	Details
A	GLU219

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:8031754, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	ASP124

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	ASP158
A	GLY190
A	ASP194

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0000269\|PubMed:9484219, ECO:0007744\|PDB:1AYK, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2AYK, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3AYK, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:4AYK, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	HIS168
A	HIS183
A	HIS196
A	HIS218
A	HIS222
A	HIS228

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0000269\|PubMed:9484219, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2AYK, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	ASP170

site_id	SWS_FT_FI6
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	ASP175

site_id	SWS_FT_FI7
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0000269\|PubMed:9484219, ECO:0007744\|PDB:1AYK, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2AYK, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:4AYK, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	GLY176

site_id	SWS_FT_FI8
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0000269\|PubMed:9484219, ECO:0007744\|PDB:1AYK, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2AYK, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	GLY178
A	ASN180

site_id	SWS_FT_FI9
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	GLY192

site_id	SWS_FT_FI10
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3AYK, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:4AYK, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	ASP198

site_id	SWS_FT_FI11
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:8031754, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	GLU199

site_id	SWS_FT_FI12
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:7656013, ECO:0000269\|PubMed:8031754, ECO:0000269\|PubMed:8090713, ECO:0000269\|PubMed:8278810, ECO:0000269\|PubMed:9484219, ECO:0007744\|PDB:1AYK, ECO:0007744\|PDB:1CGE, ECO:0007744\|PDB:1CGF, ECO:0007744\|PDB:1CGL, ECO:0007744\|PDB:1HFC, ECO:0007744\|PDB:1SU3, ECO:0007744\|PDB:2AYK, ECO:0007744\|PDB:2CLT, ECO:0007744\|PDB:2J0T, ECO:0007744\|PDB:2TCL, ECO:0007744\|PDB:3AYK, ECO:0007744\|PDB:3SHI, ECO:0007744\|PDB:4AUO, ECO:0007744\|PDB:966C

Chain	Residue	Details
A	GLU201

site_id	SWS_FT_FI13
Number of Residues	1
Details	SITE: Not glycosylated => ECO:0000269\|PubMed:10092871

Chain	Residue	Details
A	ASN143

site_id	SWS_FT_FI14
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:10092871

Chain	Residue	Details
A	ASN120

218853

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