966C
CRYSTAL STRUCTURE OF FIBROBLAST COLLAGENASE-1 COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN A 265 |
Chain | Residue |
A | RS21 |
A | HIS218 |
A | HIS222 |
A | HIS228 |
A | HOH297 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN A 266 |
Chain | Residue |
A | HIS196 |
A | HIS168 |
A | ASP170 |
A | HIS183 |
A | PHE185 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 267 |
Chain | Residue |
A | ASP175 |
A | GLY176 |
A | GLY178 |
A | ASN180 |
A | ASP198 |
A | GLU201 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 268 |
Chain | Residue |
A | ASP158 |
A | GLY190 |
A | GLY192 |
A | ASP194 |
A | HOH310 |
A | HOH353 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA A 269 |
Chain | Residue |
A | ASP124 |
A | GLU199 |
A | GLU201 |
A | HOH278 |
A | HOH279 |
site_id | AC6 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE RS2 A 1 |
Chain | Residue |
A | ASN180 |
A | LEU181 |
A | ALA182 |
A | PHE207 |
A | ARG208 |
A | GLU209 |
A | HIS218 |
A | GLU219 |
A | HIS222 |
A | HIS228 |
A | LEU235 |
A | TYR237 |
A | SER239 |
A | TYR240 |
A | THR241 |
A | ZN265 |
A | HOH297 |
A | HOH336 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHELGHSL |
Chain | Residue | Details |
A | VAL215-LEU224 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: |
Chain | Residue | Details |
A | GLU219 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP124 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP158 | |
A | GLY190 | |
A | ASP194 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | HIS168 | |
A | HIS183 | |
A | HIS196 | |
A | HIS218 | |
A | HIS222 | |
A | HIS228 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP170 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP175 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLY176 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLY178 | |
A | ASN180 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLY192 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP198 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLU199 |
site_id | SWS_FT_FI12 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLU201 |
site_id | SWS_FT_FI13 |
Number of Residues | 1 |
Details | SITE: Not glycosylated => ECO:0000269|PubMed:10092871 |
Chain | Residue | Details |
A | ASN143 |
site_id | SWS_FT_FI14 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10092871 |
Chain | Residue | Details |
A | ASN120 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | MET236 | |
A | GLU219 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | GLU219 |