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8ZYY

Cryo-EM structure of neurotensin receptor 1 in complex with beta-arrestin1 and SBI-553 (complex 2)

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
B0000139cellular_componentGolgi membrane
B0000785cellular_componentchromatin
B0001664molecular_functionG protein-coupled receptor binding
B0001934biological_processpositive regulation of protein phosphorylation
B0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
B0002031biological_processG protein-coupled receptor internalization
B0002092biological_processpositive regulation of receptor internalization
B0003713molecular_functiontranscription coactivator activity
B0004402molecular_functionhistone acetyltransferase activity
B0004857molecular_functionenzyme inhibitor activity
B0005096molecular_functionGTPase activator activity
B0005159molecular_functioninsulin-like growth factor receptor binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005905cellular_componentclathrin-coated pit
B0006357biological_processregulation of transcription by RNA polymerase II
B0006511biological_processubiquitin-dependent protein catabolic process
B0007600biological_processsensory perception
B0009968biological_processnegative regulation of signal transduction
B0010613biological_processpositive regulation of cardiac muscle hypertrophy
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0016567biological_processprotein ubiquitination
B0016604cellular_componentnuclear body
B0019899molecular_functionenzyme binding
B0030659cellular_componentcytoplasmic vesicle membrane
B0030666cellular_componentendocytic vesicle membrane
B0031143cellular_componentpseudopodium
B0031397biological_processnegative regulation of protein ubiquitination
B0031410cellular_componentcytoplasmic vesicle
B0031625molecular_functionubiquitin protein ligase binding
B0031701molecular_functionangiotensin receptor binding
B0032088biological_processnegative regulation of NF-kappaB transcription factor activity
B0032715biological_processnegative regulation of interleukin-6 production
B0032717biological_processnegative regulation of interleukin-8 production
B0035025biological_processpositive regulation of Rho protein signal transduction
B0042995cellular_componentcell projection
B0043149biological_processstress fiber assembly
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0045746biological_processnegative regulation of Notch signaling pathway
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0060090molecular_functionmolecular adaptor activity
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B1902533biological_processpositive regulation of intracellular signal transduction
B1990763molecular_functionarrestin family protein binding
R0001659biological_processtemperature homeostasis
R0003085biological_processnegative regulation of systemic arterial blood pressure
R0003254biological_processregulation of membrane depolarization
R0004930molecular_functionG protein-coupled receptor activity
R0005515molecular_functionprotein binding
R0005783cellular_componentendoplasmic reticulum
R0005794cellular_componentGolgi apparatus
R0005886cellular_componentplasma membrane
R0006171biological_processcAMP biosynthetic process
R0006950biological_processresponse to stress
R0007165biological_processsignal transduction
R0007186biological_processG protein-coupled receptor signaling pathway
R0007218biological_processneuropeptide signaling pathway
R0007268biological_processchemical synaptic transmission
R0007612biological_processlearning
R0008306biological_processassociative learning
R0008344biological_processadult locomotory behavior
R0009898cellular_componentcytoplasmic side of plasma membrane
R0009986cellular_componentcell surface
R0010628biological_processpositive regulation of gene expression
R0014049biological_processpositive regulation of glutamate secretion
R0014054biological_processpositive regulation of gamma-aminobutyric acid secretion
R0016020cellular_componentmembrane
R0016492molecular_functionG protein-coupled neurotensin receptor activity
R0030424cellular_componentaxon
R0030425cellular_componentdendrite
R0032094biological_processresponse to food
R0032280cellular_componentsymmetric synapse
R0032960biological_processregulation of inositol trisphosphate biosynthetic process
R0033993biological_processresponse to lipid
R0040017biological_processpositive regulation of locomotion
R0042597cellular_componentperiplasmic space
R0042802molecular_functionidentical protein binding
R0043025cellular_componentneuronal cell body
R0043065biological_processpositive regulation of apoptotic process
R0043066biological_processnegative regulation of apoptotic process
R0043195cellular_componentterminal bouton
R0043197cellular_componentdendritic spine
R0043198cellular_componentdendritic shaft
R0043204cellular_componentperikaryon
R0043576biological_processregulation of respiratory gaseous exchange
R0043679cellular_componentaxon terminus
R0044309cellular_componentneuron spine
R0044877molecular_functionprotein-containing complex binding
R0045121cellular_componentmembrane raft
R0046872molecular_functionmetal ion binding
R0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
R0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
R0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
R0060732biological_processpositive regulation of inositol phosphate biosynthetic process
R0070779biological_processD-aspartate import across plasma membrane
R0071545biological_processinositol phosphate catabolic process
R0071625biological_processvocalization behavior
R0090238biological_processpositive regulation of arachidonate secretion
R0097151biological_processpositive regulation of inhibitory postsynaptic potential
R0098712biological_processL-glutamate import across plasma membrane
R1990708biological_processconditioned place preference
R2000822biological_processregulation of behavioral fear response
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ATAlNVASLSVERYLaI
ChainResidueDetails
RALA154-ILE170

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
ChainResidueDetails
DTYR224-HIS230
QTYR213-HIS219

site_idPS00295
Number of Residues19
DetailsARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL
ChainResidueDetails
BPHE60-LEU78

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues41
DetailsRegion: {"description":"Interaction with CHRM2","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues11
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8BWG8","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues32
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues36
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues23
DetailsRegion: {"description":"Neurotensin binding","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues1
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"21725197","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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