8ZYQ
Cryo-EM Structure of pimozide-bound hERG Channel
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005249 | molecular_function | voltage-gated potassium channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005249 | molecular_function | voltage-gated potassium channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005249 | molecular_function | voltage-gated potassium channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005249 | molecular_function | voltage-gated potassium channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3716 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET211-THR613 | |
| C | ARG472-LYS495 | |
| C | TYR542-ALA547 | |
| D | MET211-THR613 | |
| D | ARG472-LYS495 | |
| D | TYR542-ALA547 | |
| A | ARG472-LYS495 | |
| A | TYR542-ALA547 | |
| B | MET211-THR613 | |
| B | ARG472-LYS495 | |
| B | TYR542-ALA547 | |
| C | MET211-THR613 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S1 => ECO:0000255 |
| Chain | Residue | Details |
| A | SER404-PHE424 | |
| B | SER404-PHE424 | |
| C | SER404-PHE424 | |
| D | SER404-PHE424 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 300 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | THR425-GLN450 | |
| C | SER517-LEU520 | |
| C | TYR569-TYR611 | |
| C | ASN633-LYS638 | |
| D | THR425-GLN450 | |
| D | SER517-LEU520 | |
| D | TYR569-TYR611 | |
| D | ASN633-LYS638 | |
| A | SER517-LEU520 | |
| A | TYR569-TYR611 | |
| A | ASN633-LYS638 | |
| B | THR425-GLN450 | |
| B | SER517-LEU520 | |
| B | TYR569-TYR611 | |
| B | ASN633-LYS638 | |
| C | THR425-GLN450 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S2 => ECO:0000255 |
| Chain | Residue | Details |
| A | PRO451-PHE471 | |
| B | PRO451-PHE471 | |
| C | PRO451-PHE471 | |
| D | PRO451-PHE471 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S3 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY496-GLY516 | |
| B | GLY496-GLY516 | |
| C | GLY496-GLY516 | |
| D | GLY496-GLY516 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE521-ARG541 | |
| B | ILE521-ARG541 | |
| C | ILE521-ARG541 | |
| D | ILE521-ARG541 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S5 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA548-TRP568 | |
| B | ALA548-TRP568 | |
| C | ALA548-TRP568 | |
| D | ALA548-TRP568 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 80 |
| Details | INTRAMEM: Pore-forming; Name=Segment H5 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL612-PRO632 | |
| B | VAL612-PRO632 | |
| C | VAL612-PRO632 | |
| D | VAL612-PRO632 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S6 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE639-VAL659 | |
| B | ILE639-VAL659 | |
| C | ILE639-VAL659 | |
| D | ILE639-VAL659 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | CYS449 | |
| D | CYS449 | |
| D | SER1002 | |
| A | SER1002 | |
| B | CYS449 | |
| B | SER1002 | |
| C | CYS449 | |
| C | SER1002 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 16 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O35219 |
| Chain | Residue | Details |
| A | ALA453 | |
| C | TYR493 | |
| C | PHE494 | |
| D | ALA453 | |
| D | TYR493 | |
| D | PHE494 | |
| A | TYR493 | |
| A | PHE494 | |
| B | ALA453 | |
| B | TYR493 | |
| B | PHE494 | |
| C | ALA453 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | LEU530 | |
| B | LEU530 | |
| C | LEU530 | |
| D | LEU530 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O08962 |
| Chain | Residue | Details |
| A | SER351 | |
| B | SER351 | |
| C | SER351 | |
| D | SER351 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:O35219 |
| Chain | Residue | Details |
| A | ARG879 | |
| B | ARG879 | |
| C | ARG879 | |
| D | ARG879 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12063277 |
| Chain | Residue | Details |
| A | ASN598 | |
| B | ASN598 | |
| C | ASN598 | |
| D | ASN598 |
