8ZVQ

Cryo-EM Structure of Human Hormone-sensitive Lipase (HSL)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008203	biological_process	cholesterol metabolic process
A	0016042	biological_process	lipid catabolic process
A	0016298	molecular_function	lipase activity
A	0016787	molecular_function	hydrolase activity
B	0008203	biological_process	cholesterol metabolic process
B	0016042	biological_process	lipid catabolic process
B	0016298	molecular_function	lipase activity
B	0016787	molecular_function	hydrolase activity

Functional Information from PROSITE/UniProt

site_id	PS01173
Number of Residues	17
Details	LIPASE_GDXG_HIS Lipolytic enzymes "G-D-X-G" family, putative histidine active site. IVhFHGGGFvaqTsrSH

Chain	Residue	Details
A	ILE346-HIS362

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site_id	PS01174
Number of Residues	13
Details	LIPASE_GDXG_SER Lipolytic enzymes "G-D-X-G" family, putative serine active site. IcLAGDSAGGnLC

Chain	Residue	Details
A	ILE418-CYS430

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Motif: {"description":"Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole","evidences":[{"source":"UniProtKB","id":"Q5NUF3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"Q8BLF1","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU10038","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"Q8BLF1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P15304","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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