8ZVQ
Cryo-EM Structure of Human Hormone-sensitive Lipase (HSL)
Functional Information from PROSITE/UniProt
| site_id | PS01173 |
| Number of Residues | 17 |
| Details | LIPASE_GDXG_HIS Lipolytic enzymes "G-D-X-G" family, putative histidine active site. IVhFHGGGFvaqTsrSH |
| Chain | Residue | Details |
| A | ILE346-HIS362 |
| site_id | PS01174 |
| Number of Residues | 13 |
| Details | LIPASE_GDXG_SER Lipolytic enzymes "G-D-X-G" family, putative serine active site. IcLAGDSAGGnLC |
| Chain | Residue | Details |
| A | ILE418-CYS430 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:Q8BLF1, ECO:0000255|PROSITE-ProRule:PRU10038 |
| Chain | Residue | Details |
| A | SER424 | |
| B | SER424 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:Q8BLF1 |
| Chain | Residue | Details |
| A | ASP693 | |
| A | HIS723 | |
| B | ASP693 | |
| B | HIS723 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P16386 |
| Chain | Residue | Details |
| A | SER552 | |
| B | SER552 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by AMPK => ECO:0000250|UniProtKB:P16386 |
| Chain | Residue | Details |
| A | SER554 | |
| B | SER554 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P15304 |
| Chain | Residue | Details |
| A | SER596 | |
| A | SER628 | |
| A | SER649 | |
| A | SER650 | |
| B | SER596 | |
| B | SER628 | |
| B | SER649 | |
| B | SER650 |
