8ZUK

Cluster structure of the BAFF-BAFFR-TRAF3 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0001817	biological_process	regulation of cytokine production
a	0005164	molecular_function	tumor necrosis factor receptor binding
a	0007165	biological_process	signal transduction
a	0008063	biological_process	Toll signaling pathway
a	0008270	molecular_function	zinc ion binding
a	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
a	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
a	0042981	biological_process	regulation of apoptotic process
a	0045087	biological_process	innate immune response
a	0050688	biological_process	regulation of defense response to virus
A	0001817	biological_process	regulation of cytokine production
A	0005164	molecular_function	tumor necrosis factor receptor binding
A	0007165	biological_process	signal transduction
A	0008063	biological_process	Toll signaling pathway
A	0008270	molecular_function	zinc ion binding
A	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
A	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
A	0042981	biological_process	regulation of apoptotic process
A	0045087	biological_process	innate immune response
A	0050688	biological_process	regulation of defense response to virus
b	0002250	biological_process	adaptive immune response
b	0002376	biological_process	immune system process
b	0005886	cellular_component	plasma membrane
b	0009897	cellular_component	external side of plasma membrane
b	0016020	cellular_component	membrane
b	0030890	biological_process	positive regulation of B cell proliferation
b	0031295	biological_process	T cell costimulation
b	0031296	biological_process	B cell costimulation
b	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
b	0038023	molecular_function	signaling receptor activity
b	0042102	biological_process	positive regulation of T cell proliferation
B	0001817	biological_process	regulation of cytokine production
B	0005164	molecular_function	tumor necrosis factor receptor binding
B	0007165	biological_process	signal transduction
B	0008063	biological_process	Toll signaling pathway
B	0008270	molecular_function	zinc ion binding
B	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
B	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
B	0042981	biological_process	regulation of apoptotic process
B	0045087	biological_process	innate immune response
B	0050688	biological_process	regulation of defense response to virus
c	0002250	biological_process	adaptive immune response
c	0002376	biological_process	immune system process
c	0005886	cellular_component	plasma membrane
c	0009897	cellular_component	external side of plasma membrane
c	0016020	cellular_component	membrane
c	0030890	biological_process	positive regulation of B cell proliferation
c	0031295	biological_process	T cell costimulation
c	0031296	biological_process	B cell costimulation
c	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
c	0038023	molecular_function	signaling receptor activity
c	0042102	biological_process	positive regulation of T cell proliferation
C	0001817	biological_process	regulation of cytokine production
C	0005164	molecular_function	tumor necrosis factor receptor binding
C	0007165	biological_process	signal transduction
C	0008063	biological_process	Toll signaling pathway
C	0008270	molecular_function	zinc ion binding
C	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
C	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
C	0042981	biological_process	regulation of apoptotic process
C	0045087	biological_process	innate immune response
C	0050688	biological_process	regulation of defense response to virus
d	0002250	biological_process	adaptive immune response
d	0002376	biological_process	immune system process
d	0005886	cellular_component	plasma membrane
d	0009897	cellular_component	external side of plasma membrane
d	0016020	cellular_component	membrane
d	0030890	biological_process	positive regulation of B cell proliferation
d	0031295	biological_process	T cell costimulation
d	0031296	biological_process	B cell costimulation
d	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
d	0038023	molecular_function	signaling receptor activity
d	0042102	biological_process	positive regulation of T cell proliferation
D	0002250	biological_process	adaptive immune response
D	0002376	biological_process	immune system process
D	0005886	cellular_component	plasma membrane
D	0009897	cellular_component	external side of plasma membrane
D	0016020	cellular_component	membrane
D	0030890	biological_process	positive regulation of B cell proliferation
D	0031295	biological_process	T cell costimulation
D	0031296	biological_process	B cell costimulation
D	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
D	0038023	molecular_function	signaling receptor activity
D	0042102	biological_process	positive regulation of T cell proliferation
e	0001817	biological_process	regulation of cytokine production
e	0005164	molecular_function	tumor necrosis factor receptor binding
e	0007165	biological_process	signal transduction
e	0008063	biological_process	Toll signaling pathway
e	0008270	molecular_function	zinc ion binding
e	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
e	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
e	0042981	biological_process	regulation of apoptotic process
e	0045087	biological_process	innate immune response
e	0050688	biological_process	regulation of defense response to virus
E	0002250	biological_process	adaptive immune response
E	0002376	biological_process	immune system process
E	0005886	cellular_component	plasma membrane
E	0009897	cellular_component	external side of plasma membrane
E	0016020	cellular_component	membrane
E	0030890	biological_process	positive regulation of B cell proliferation
E	0031295	biological_process	T cell costimulation
E	0031296	biological_process	B cell costimulation
E	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
E	0038023	molecular_function	signaling receptor activity
E	0042102	biological_process	positive regulation of T cell proliferation
f	0001817	biological_process	regulation of cytokine production
f	0005164	molecular_function	tumor necrosis factor receptor binding
f	0007165	biological_process	signal transduction
f	0008063	biological_process	Toll signaling pathway
f	0008270	molecular_function	zinc ion binding
f	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
f	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
f	0042981	biological_process	regulation of apoptotic process
f	0045087	biological_process	innate immune response
f	0050688	biological_process	regulation of defense response to virus
F	0002250	biological_process	adaptive immune response
F	0002376	biological_process	immune system process
F	0005886	cellular_component	plasma membrane
F	0009897	cellular_component	external side of plasma membrane
F	0016020	cellular_component	membrane
F	0030890	biological_process	positive regulation of B cell proliferation
F	0031295	biological_process	T cell costimulation
F	0031296	biological_process	B cell costimulation
F	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
F	0038023	molecular_function	signaling receptor activity
F	0042102	biological_process	positive regulation of T cell proliferation
g	0001817	biological_process	regulation of cytokine production
g	0005164	molecular_function	tumor necrosis factor receptor binding
g	0007165	biological_process	signal transduction
g	0008063	biological_process	Toll signaling pathway
g	0008270	molecular_function	zinc ion binding
g	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
g	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
g	0042981	biological_process	regulation of apoptotic process
g	0045087	biological_process	innate immune response
g	0050688	biological_process	regulation of defense response to virus
G	0001817	biological_process	regulation of cytokine production
G	0005164	molecular_function	tumor necrosis factor receptor binding
G	0007165	biological_process	signal transduction
G	0008063	biological_process	Toll signaling pathway
G	0008270	molecular_function	zinc ion binding
G	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
G	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
G	0042981	biological_process	regulation of apoptotic process
G	0045087	biological_process	innate immune response
G	0050688	biological_process	regulation of defense response to virus
h	0002250	biological_process	adaptive immune response
h	0002376	biological_process	immune system process
h	0005886	cellular_component	plasma membrane
h	0009897	cellular_component	external side of plasma membrane
h	0016020	cellular_component	membrane
h	0030890	biological_process	positive regulation of B cell proliferation
h	0031295	biological_process	T cell costimulation
h	0031296	biological_process	B cell costimulation
h	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
h	0038023	molecular_function	signaling receptor activity
h	0042102	biological_process	positive regulation of T cell proliferation
H	0001817	biological_process	regulation of cytokine production
H	0005164	molecular_function	tumor necrosis factor receptor binding
H	0007165	biological_process	signal transduction
H	0008063	biological_process	Toll signaling pathway
H	0008270	molecular_function	zinc ion binding
H	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
H	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
H	0042981	biological_process	regulation of apoptotic process
H	0045087	biological_process	innate immune response
H	0050688	biological_process	regulation of defense response to virus
i	0002250	biological_process	adaptive immune response
i	0002376	biological_process	immune system process
i	0005886	cellular_component	plasma membrane
i	0009897	cellular_component	external side of plasma membrane
i	0016020	cellular_component	membrane
i	0030890	biological_process	positive regulation of B cell proliferation
i	0031295	biological_process	T cell costimulation
i	0031296	biological_process	B cell costimulation
i	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
i	0038023	molecular_function	signaling receptor activity
i	0042102	biological_process	positive regulation of T cell proliferation
I	0001817	biological_process	regulation of cytokine production
I	0005164	molecular_function	tumor necrosis factor receptor binding
I	0007165	biological_process	signal transduction
I	0008063	biological_process	Toll signaling pathway
I	0008270	molecular_function	zinc ion binding
I	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
I	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
I	0042981	biological_process	regulation of apoptotic process
I	0045087	biological_process	innate immune response
I	0050688	biological_process	regulation of defense response to virus
j	0002250	biological_process	adaptive immune response
j	0002376	biological_process	immune system process
j	0005886	cellular_component	plasma membrane
j	0009897	cellular_component	external side of plasma membrane
j	0016020	cellular_component	membrane
j	0030890	biological_process	positive regulation of B cell proliferation
j	0031295	biological_process	T cell costimulation
j	0031296	biological_process	B cell costimulation
j	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
j	0038023	molecular_function	signaling receptor activity
j	0042102	biological_process	positive regulation of T cell proliferation
J	0002250	biological_process	adaptive immune response
J	0002376	biological_process	immune system process
J	0005886	cellular_component	plasma membrane
J	0009897	cellular_component	external side of plasma membrane
J	0016020	cellular_component	membrane
J	0030890	biological_process	positive regulation of B cell proliferation
J	0031295	biological_process	T cell costimulation
J	0031296	biological_process	B cell costimulation
J	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
J	0038023	molecular_function	signaling receptor activity
J	0042102	biological_process	positive regulation of T cell proliferation
k	0001817	biological_process	regulation of cytokine production
k	0005164	molecular_function	tumor necrosis factor receptor binding
k	0007165	biological_process	signal transduction
k	0008063	biological_process	Toll signaling pathway
k	0008270	molecular_function	zinc ion binding
k	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
k	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
k	0042981	biological_process	regulation of apoptotic process
k	0045087	biological_process	innate immune response
k	0050688	biological_process	regulation of defense response to virus
K	0002250	biological_process	adaptive immune response
K	0002376	biological_process	immune system process
K	0005886	cellular_component	plasma membrane
K	0009897	cellular_component	external side of plasma membrane
K	0016020	cellular_component	membrane
K	0030890	biological_process	positive regulation of B cell proliferation
K	0031295	biological_process	T cell costimulation
K	0031296	biological_process	B cell costimulation
K	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
K	0038023	molecular_function	signaling receptor activity
K	0042102	biological_process	positive regulation of T cell proliferation
l	0001817	biological_process	regulation of cytokine production
l	0005164	molecular_function	tumor necrosis factor receptor binding
l	0007165	biological_process	signal transduction
l	0008063	biological_process	Toll signaling pathway
l	0008270	molecular_function	zinc ion binding
l	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
l	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
l	0042981	biological_process	regulation of apoptotic process
l	0045087	biological_process	innate immune response
l	0050688	biological_process	regulation of defense response to virus
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0005886	cellular_component	plasma membrane
L	0009897	cellular_component	external side of plasma membrane
L	0016020	cellular_component	membrane
L	0030890	biological_process	positive regulation of B cell proliferation
L	0031295	biological_process	T cell costimulation
L	0031296	biological_process	B cell costimulation
L	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
L	0038023	molecular_function	signaling receptor activity
L	0042102	biological_process	positive regulation of T cell proliferation
m	0001817	biological_process	regulation of cytokine production
m	0005164	molecular_function	tumor necrosis factor receptor binding
m	0007165	biological_process	signal transduction
m	0008063	biological_process	Toll signaling pathway
m	0008270	molecular_function	zinc ion binding
m	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
m	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
m	0042981	biological_process	regulation of apoptotic process
m	0045087	biological_process	innate immune response
m	0050688	biological_process	regulation of defense response to virus
M	0001817	biological_process	regulation of cytokine production
M	0005164	molecular_function	tumor necrosis factor receptor binding
M	0007165	biological_process	signal transduction
M	0008063	biological_process	Toll signaling pathway
M	0008270	molecular_function	zinc ion binding
M	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
M	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
M	0042981	biological_process	regulation of apoptotic process
M	0045087	biological_process	innate immune response
M	0050688	biological_process	regulation of defense response to virus
n	0002250	biological_process	adaptive immune response
n	0002376	biological_process	immune system process
n	0005886	cellular_component	plasma membrane
n	0009897	cellular_component	external side of plasma membrane
n	0016020	cellular_component	membrane
n	0030890	biological_process	positive regulation of B cell proliferation
n	0031295	biological_process	T cell costimulation
n	0031296	biological_process	B cell costimulation
n	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
n	0038023	molecular_function	signaling receptor activity
n	0042102	biological_process	positive regulation of T cell proliferation
N	0001817	biological_process	regulation of cytokine production
N	0005164	molecular_function	tumor necrosis factor receptor binding
N	0007165	biological_process	signal transduction
N	0008063	biological_process	Toll signaling pathway
N	0008270	molecular_function	zinc ion binding
N	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
N	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
N	0042981	biological_process	regulation of apoptotic process
N	0045087	biological_process	innate immune response
N	0050688	biological_process	regulation of defense response to virus
o	0002250	biological_process	adaptive immune response
o	0002376	biological_process	immune system process
o	0005886	cellular_component	plasma membrane
o	0009897	cellular_component	external side of plasma membrane
o	0016020	cellular_component	membrane
o	0030890	biological_process	positive regulation of B cell proliferation
o	0031295	biological_process	T cell costimulation
o	0031296	biological_process	B cell costimulation
o	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
o	0038023	molecular_function	signaling receptor activity
o	0042102	biological_process	positive regulation of T cell proliferation
O	0001817	biological_process	regulation of cytokine production
O	0005164	molecular_function	tumor necrosis factor receptor binding
O	0007165	biological_process	signal transduction
O	0008063	biological_process	Toll signaling pathway
O	0008270	molecular_function	zinc ion binding
O	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
O	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
O	0042981	biological_process	regulation of apoptotic process
O	0045087	biological_process	innate immune response
O	0050688	biological_process	regulation of defense response to virus
p	0002250	biological_process	adaptive immune response
p	0002376	biological_process	immune system process
p	0005886	cellular_component	plasma membrane
p	0009897	cellular_component	external side of plasma membrane
p	0016020	cellular_component	membrane
p	0030890	biological_process	positive regulation of B cell proliferation
p	0031295	biological_process	T cell costimulation
p	0031296	biological_process	B cell costimulation
p	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
p	0038023	molecular_function	signaling receptor activity
p	0042102	biological_process	positive regulation of T cell proliferation
P	0002250	biological_process	adaptive immune response
P	0002376	biological_process	immune system process
P	0005886	cellular_component	plasma membrane
P	0009897	cellular_component	external side of plasma membrane
P	0016020	cellular_component	membrane
P	0030890	biological_process	positive regulation of B cell proliferation
P	0031295	biological_process	T cell costimulation
P	0031296	biological_process	B cell costimulation
P	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
P	0038023	molecular_function	signaling receptor activity
P	0042102	biological_process	positive regulation of T cell proliferation
Q	0002250	biological_process	adaptive immune response
Q	0002376	biological_process	immune system process
Q	0005886	cellular_component	plasma membrane
Q	0009897	cellular_component	external side of plasma membrane
Q	0016020	cellular_component	membrane
Q	0030890	biological_process	positive regulation of B cell proliferation
Q	0031295	biological_process	T cell costimulation
Q	0031296	biological_process	B cell costimulation
Q	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
Q	0038023	molecular_function	signaling receptor activity
Q	0042102	biological_process	positive regulation of T cell proliferation
R	0002250	biological_process	adaptive immune response
R	0002376	biological_process	immune system process
R	0005886	cellular_component	plasma membrane
R	0009897	cellular_component	external side of plasma membrane
R	0016020	cellular_component	membrane
R	0030890	biological_process	positive regulation of B cell proliferation
R	0031295	biological_process	T cell costimulation
R	0031296	biological_process	B cell costimulation
R	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
R	0038023	molecular_function	signaling receptor activity
R	0042102	biological_process	positive regulation of T cell proliferation
S	0001817	biological_process	regulation of cytokine production
S	0005164	molecular_function	tumor necrosis factor receptor binding
S	0007165	biological_process	signal transduction
S	0008063	biological_process	Toll signaling pathway
S	0008270	molecular_function	zinc ion binding
S	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
S	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
S	0042981	biological_process	regulation of apoptotic process
S	0045087	biological_process	innate immune response
S	0050688	biological_process	regulation of defense response to virus
T	0001817	biological_process	regulation of cytokine production
T	0005164	molecular_function	tumor necrosis factor receptor binding
T	0007165	biological_process	signal transduction
T	0008063	biological_process	Toll signaling pathway
T	0008270	molecular_function	zinc ion binding
T	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
T	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
T	0042981	biological_process	regulation of apoptotic process
T	0045087	biological_process	innate immune response
T	0050688	biological_process	regulation of defense response to virus
U	0001817	biological_process	regulation of cytokine production
U	0005164	molecular_function	tumor necrosis factor receptor binding
U	0007165	biological_process	signal transduction
U	0008063	biological_process	Toll signaling pathway
U	0008270	molecular_function	zinc ion binding
U	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
U	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
U	0042981	biological_process	regulation of apoptotic process
U	0045087	biological_process	innate immune response
U	0050688	biological_process	regulation of defense response to virus
V	0002250	biological_process	adaptive immune response
V	0002376	biological_process	immune system process
V	0005886	cellular_component	plasma membrane
V	0009897	cellular_component	external side of plasma membrane
V	0016020	cellular_component	membrane
V	0030890	biological_process	positive regulation of B cell proliferation
V	0031295	biological_process	T cell costimulation
V	0031296	biological_process	B cell costimulation
V	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
V	0038023	molecular_function	signaling receptor activity
V	0042102	biological_process	positive regulation of T cell proliferation
W	0002250	biological_process	adaptive immune response
W	0002376	biological_process	immune system process
W	0005886	cellular_component	plasma membrane
W	0009897	cellular_component	external side of plasma membrane
W	0016020	cellular_component	membrane
W	0030890	biological_process	positive regulation of B cell proliferation
W	0031295	biological_process	T cell costimulation
W	0031296	biological_process	B cell costimulation
W	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
W	0038023	molecular_function	signaling receptor activity
W	0042102	biological_process	positive regulation of T cell proliferation
X	0002250	biological_process	adaptive immune response
X	0002376	biological_process	immune system process
X	0005886	cellular_component	plasma membrane
X	0009897	cellular_component	external side of plasma membrane
X	0016020	cellular_component	membrane
X	0030890	biological_process	positive regulation of B cell proliferation
X	0031295	biological_process	T cell costimulation
X	0031296	biological_process	B cell costimulation
X	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
X	0038023	molecular_function	signaling receptor activity
X	0042102	biological_process	positive regulation of T cell proliferation
Y	0001817	biological_process	regulation of cytokine production
Y	0005164	molecular_function	tumor necrosis factor receptor binding
Y	0007165	biological_process	signal transduction
Y	0008063	biological_process	Toll signaling pathway
Y	0008270	molecular_function	zinc ion binding
Y	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
Y	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
Y	0042981	biological_process	regulation of apoptotic process
Y	0045087	biological_process	innate immune response
Y	0050688	biological_process	regulation of defense response to virus
Z	0001817	biological_process	regulation of cytokine production
Z	0005164	molecular_function	tumor necrosis factor receptor binding
Z	0007165	biological_process	signal transduction
Z	0008063	biological_process	Toll signaling pathway
Z	0008270	molecular_function	zinc ion binding
Z	0032088	biological_process	negative regulation of NF-kappaB transcription factor activity
Z	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
Z	0042981	biological_process	regulation of apoptotic process
Z	0045087	biological_process	innate immune response
Z	0050688	biological_process	regulation of defense response to virus

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3045
Details	Domain: {"description":"MATH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00129","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	483
Details	Region: {"description":"(Microbial infection) Interaction with glycoprotein N of Andes and New York hantaviruses","evidences":[{"source":"PubMed","id":"24390324","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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