8ZUF

Cryo-EM structure of P.nat ACE2 mutant in complex with MOW15-22 RBD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0001618	molecular_function	virus receptor activity
A	0002003	biological_process	angiotensin maturation
A	0003051	biological_process	angiotensin-mediated drinking behavior
A	0003081	biological_process	regulation of systemic arterial blood pressure by renin-angiotensin
A	0004175	molecular_function	endopeptidase activity
A	0004180	molecular_function	carboxypeptidase activity
A	0004181	molecular_function	metallocarboxypeptidase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008241	molecular_function	peptidyl-dipeptidase activity
A	0009986	cellular_component	cell surface
A	0015827	biological_process	tryptophan transport
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0016787	molecular_function	hydrolase activity
A	0031526	cellular_component	brush border membrane
A	0042802	molecular_function	identical protein binding
A	0042995	cellular_component	cell projection
A	0046718	biological_process	symbiont entry into host cell
A	0046813	biological_process	receptor-mediated virion attachment to host cell
A	0046872	molecular_function	metal ion binding
A	0050727	biological_process	regulation of inflammatory response
A	0051957	biological_process	positive regulation of amino acid transport
A	0060452	biological_process	positive regulation of cardiac muscle contraction
A	0098670	biological_process	entry receptor-mediated virion attachment to host cell
A	0141109	molecular_function	transporter activator activity
A	1903598	biological_process	positive regulation of gap junction assembly
A	1903779	biological_process	regulation of cardiac conduction
A	1905737	biological_process	positive regulation of L-proline import across plasma membrane

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ

Chain	Residue	Details
A	THR371-GLN380

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9BYF1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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