8ZU8
Human PIEZO1-A1988V
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| C | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YQCVAAH |
| Chain | Residue | Details |
| A | TYR1680-HIS1686 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 60 |
| Details | Transmembrane: {"description":"Helical; Name=13"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Topological domain: {"description":"Extracellular"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | Transmembrane: {"description":"Helical; Name=14"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 27 |
| Details | Topological domain: {"description":"Cytoplasmic"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=16"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 33 |
| Details | Transmembrane: {"description":"Helical; Name=17","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 729 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 39 |
| Details | Transmembrane: {"description":"Helical; Name=18","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 672 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=19","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 81 |
| Details | Transmembrane: {"description":"Helical; Name=20","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 45 |
| Details | Transmembrane: {"description":"Helical; Name=21","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 45 |
| Details | Transmembrane: {"description":"Helical; Name=22","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 45 |
| Details | Transmembrane: {"description":"Helical; Name=23","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 63 |
| Details | Transmembrane: {"description":"Helical; Name=24","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 78 |
| Details | Transmembrane: {"description":"Helical; Name=25","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=26","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=28","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 129 |
| Details | Transmembrane: {"description":"Helical; Name=29","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 45 |
| Details | Transmembrane: {"description":"Helical; Name=30","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=31","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 63 |
| Details | Transmembrane: {"description":"Helical; Name=32","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=33","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=34","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 45 |
| Details | Transmembrane: {"description":"Helical; Name=36","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 60 |
| Details | Transmembrane: {"description":"Helical; Name=37","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 60 |
| Details | Transmembrane: {"description":"Helical; Name=38","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI28 |
| Number of Residues | 87 |
| Details | Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI29 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI30 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
