Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8ZT5

Structure of calcium preference ATP-gated channel P2X1 in the Desensitized state 2 in the presence of 1mM Calcium ion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001614	molecular_function	purinergic nucleotide receptor activity
A	0002554	biological_process	serotonin secretion by platelet
A	0003008	biological_process	system process
A	0003056	biological_process	regulation of vascular associated smooth muscle contraction
A	0004931	molecular_function	extracellularly ATP-gated monoatomic cation channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006915	biological_process	apoptotic process
A	0006940	biological_process	regulation of smooth muscle contraction
A	0007166	biological_process	cell surface receptor signaling pathway
A	0007267	biological_process	cell-cell signaling
A	0007320	biological_process	insemination
A	0008217	biological_process	regulation of blood pressure
A	0009897	cellular_component	external side of plasma membrane
A	0019228	biological_process	neuronal action potential
A	0019229	biological_process	regulation of vasoconstriction
A	0019722	biological_process	calcium-mediated signaling
A	0030168	biological_process	platelet activation
A	0032991	cellular_component	protein-containing complex
A	0033198	biological_process	response to ATP
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035249	biological_process	synaptic transmission, glutamatergic
A	0035590	biological_process	purinergic nucleotide receptor signaling pathway
A	0042802	molecular_function	identical protein binding
A	0043270	biological_process	positive regulation of monoatomic ion transport
A	0043924	molecular_function	suramin binding
A	0044877	molecular_function	protein-containing complex binding
A	0045121	cellular_component	membrane raft
A	0045211	cellular_component	postsynaptic membrane
A	0046513	biological_process	ceramide biosynthetic process
A	0048787	cellular_component	presynaptic active zone membrane
A	0051924	biological_process	regulation of calcium ion transport
A	0060079	biological_process	excitatory postsynaptic potential
A	0070588	biological_process	calcium ion transmembrane transport
A	0098655	biological_process	monoatomic cation transmembrane transport
A	0098978	cellular_component	glutamatergic synapse
A	0099509	biological_process	regulation of presynaptic cytosolic calcium ion concentration
A	0099604	molecular_function	ligand-gated calcium channel activity
A	1905665	biological_process	positive regulation of calcium ion import across plasma membrane
A	2000300	biological_process	regulation of synaptic vesicle exocytosis
B	0000166	molecular_function	nucleotide binding
B	0001614	molecular_function	purinergic nucleotide receptor activity
B	0002554	biological_process	serotonin secretion by platelet
B	0003008	biological_process	system process
B	0003056	biological_process	regulation of vascular associated smooth muscle contraction
B	0004931	molecular_function	extracellularly ATP-gated monoatomic cation channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006915	biological_process	apoptotic process
B	0006940	biological_process	regulation of smooth muscle contraction
B	0007166	biological_process	cell surface receptor signaling pathway
B	0007267	biological_process	cell-cell signaling
B	0007320	biological_process	insemination
B	0008217	biological_process	regulation of blood pressure
B	0009897	cellular_component	external side of plasma membrane
B	0019228	biological_process	neuronal action potential
B	0019229	biological_process	regulation of vasoconstriction
B	0019722	biological_process	calcium-mediated signaling
B	0030168	biological_process	platelet activation
B	0032991	cellular_component	protein-containing complex
B	0033198	biological_process	response to ATP
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035249	biological_process	synaptic transmission, glutamatergic
B	0035590	biological_process	purinergic nucleotide receptor signaling pathway
B	0042802	molecular_function	identical protein binding
B	0043270	biological_process	positive regulation of monoatomic ion transport
B	0043924	molecular_function	suramin binding
B	0044877	molecular_function	protein-containing complex binding
B	0045121	cellular_component	membrane raft
B	0045211	cellular_component	postsynaptic membrane
B	0046513	biological_process	ceramide biosynthetic process
B	0048787	cellular_component	presynaptic active zone membrane
B	0051924	biological_process	regulation of calcium ion transport
B	0060079	biological_process	excitatory postsynaptic potential
B	0070588	biological_process	calcium ion transmembrane transport
B	0098655	biological_process	monoatomic cation transmembrane transport
B	0098978	cellular_component	glutamatergic synapse
B	0099509	biological_process	regulation of presynaptic cytosolic calcium ion concentration
B	0099604	molecular_function	ligand-gated calcium channel activity
B	1905665	biological_process	positive regulation of calcium ion import across plasma membrane
B	2000300	biological_process	regulation of synaptic vesicle exocytosis
C	0000166	molecular_function	nucleotide binding
C	0001614	molecular_function	purinergic nucleotide receptor activity
C	0002554	biological_process	serotonin secretion by platelet
C	0003008	biological_process	system process
C	0003056	biological_process	regulation of vascular associated smooth muscle contraction
C	0004931	molecular_function	extracellularly ATP-gated monoatomic cation channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006915	biological_process	apoptotic process
C	0006940	biological_process	regulation of smooth muscle contraction
C	0007166	biological_process	cell surface receptor signaling pathway
C	0007267	biological_process	cell-cell signaling
C	0007320	biological_process	insemination
C	0008217	biological_process	regulation of blood pressure
C	0009897	cellular_component	external side of plasma membrane
C	0019228	biological_process	neuronal action potential
C	0019229	biological_process	regulation of vasoconstriction
C	0019722	biological_process	calcium-mediated signaling
C	0030168	biological_process	platelet activation
C	0032991	cellular_component	protein-containing complex
C	0033198	biological_process	response to ATP
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035249	biological_process	synaptic transmission, glutamatergic
C	0035590	biological_process	purinergic nucleotide receptor signaling pathway
C	0042802	molecular_function	identical protein binding
C	0043270	biological_process	positive regulation of monoatomic ion transport
C	0043924	molecular_function	suramin binding
C	0044877	molecular_function	protein-containing complex binding
C	0045121	cellular_component	membrane raft
C	0045211	cellular_component	postsynaptic membrane
C	0046513	biological_process	ceramide biosynthetic process
C	0048787	cellular_component	presynaptic active zone membrane
C	0051924	biological_process	regulation of calcium ion transport
C	0060079	biological_process	excitatory postsynaptic potential
C	0070588	biological_process	calcium ion transmembrane transport
C	0098655	biological_process	monoatomic cation transmembrane transport
C	0098978	cellular_component	glutamatergic synapse
C	0099509	biological_process	regulation of presynaptic cytosolic calcium ion concentration
C	0099604	molecular_function	ligand-gated calcium channel activity
C	1905665	biological_process	positive regulation of calcium ion import across plasma membrane
C	2000300	biological_process	regulation of synaptic vesicle exocytosis

Functional Information from PROSITE/UniProt

site_id	PS01212
Number of Residues	27
Details	P2X_RECEPTOR ATP P2X receptors signature. GGvVGItIdWeCDLDwhvrhCkPiYqF

Chain	Residue	Details
B	GLY250-PHE276

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	861
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"P56373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	21
Details	Region: {"description":"Pore-forming motif","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"F8W463","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P56373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)