8ZSK

Complex I from respirasome closed state 1 bound by metformin and CoQ10, alternative orientation (SC-MetC1-ii)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
4L	0005743	cellular_component	mitochondrial inner membrane
4L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
4L	0022904	biological_process	respiratory electron transport chain
4L	0045271	cellular_component	respiratory chain complex I
4L	1902600	biological_process	proton transmembrane transport
A1	0005739	cellular_component	mitochondrion
A1	0005743	cellular_component	mitochondrial inner membrane
A1	0022904	biological_process	respiratory electron transport chain
A1	0031966	cellular_component	mitochondrial membrane
A1	0045271	cellular_component	respiratory chain complex I
A7	0005743	cellular_component	mitochondrial inner membrane
A7	0022904	biological_process	respiratory electron transport chain
A7	0045271	cellular_component	respiratory chain complex I
A9	0000166	molecular_function	nucleotide binding
A9	0005759	cellular_component	mitochondrial matrix
A9	0022904	biological_process	respiratory electron transport chain
AK	0000166	molecular_function	nucleotide binding
AK	0005525	molecular_function	GTP binding
AK	0005759	cellular_component	mitochondrial matrix
AK	0022904	biological_process	respiratory electron transport chain
AK	0046872	molecular_function	metal ion binding
AL	0005743	cellular_component	mitochondrial inner membrane
AL	0045271	cellular_component	respiratory chain complex I
AM	0005743	cellular_component	mitochondrial inner membrane
AM	0022904	biological_process	respiratory electron transport chain
AM	0045271	cellular_component	respiratory chain complex I
AN	0005739	cellular_component	mitochondrion
AN	0005743	cellular_component	mitochondrial inner membrane
AN	0016020	cellular_component	membrane
AN	0022904	biological_process	respiratory electron transport chain
AN	0045271	cellular_component	respiratory chain complex I
B1	0005739	cellular_component	mitochondrion
B1	0005743	cellular_component	mitochondrial inner membrane
B1	0022904	biological_process	respiratory electron transport chain
B1	0045271	cellular_component	respiratory chain complex I
B4	0005743	cellular_component	mitochondrial inner membrane
B4	0022904	biological_process	respiratory electron transport chain
B4	0045271	cellular_component	respiratory chain complex I
B7	0005743	cellular_component	mitochondrial inner membrane
B7	0005758	cellular_component	mitochondrial intermembrane space
B7	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B7	0022904	biological_process	respiratory electron transport chain
B7	0045271	cellular_component	respiratory chain complex I
B7	1902600	biological_process	proton transmembrane transport
BK	0005739	cellular_component	mitochondrion
BK	0005743	cellular_component	mitochondrial inner membrane
BK	0022904	biological_process	respiratory electron transport chain
BK	0045271	cellular_component	respiratory chain complex I
CB	0005737	cellular_component	cytoplasm
CB	0005743	cellular_component	mitochondrial inner membrane
CB	0022904	biological_process	respiratory electron transport chain
CB	0032981	biological_process	mitochondrial respiratory chain complex I assembly
CB	0045271	cellular_component	respiratory chain complex I
N1	0003954	molecular_function	NADH dehydrogenase activity
N1	0005743	cellular_component	mitochondrial inner membrane
N1	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
N1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N1	0009060	biological_process	aerobic respiration
N1	0022904	biological_process	respiratory electron transport chain
N1	0032981	biological_process	mitochondrial respiratory chain complex I assembly
N1	0045271	cellular_component	respiratory chain complex I
N1	1902600	biological_process	proton transmembrane transport
N2	0005743	cellular_component	mitochondrial inner membrane
N2	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
N2	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N2	0022904	biological_process	respiratory electron transport chain
N2	0032981	biological_process	mitochondrial respiratory chain complex I assembly
N2	0045271	cellular_component	respiratory chain complex I
N2	1902600	biological_process	proton transmembrane transport
N3	0005743	cellular_component	mitochondrial inner membrane
N3	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
N3	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N3	0022904	biological_process	respiratory electron transport chain
N3	0045271	cellular_component	respiratory chain complex I
N3	1902600	biological_process	proton transmembrane transport
N4	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N4	0022904	biological_process	respiratory electron transport chain
N4	0031966	cellular_component	mitochondrial membrane
N4	1902600	biological_process	proton transmembrane transport
N5	0005743	cellular_component	mitochondrial inner membrane
N5	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N5	0022904	biological_process	respiratory electron transport chain
N5	1902600	biological_process	proton transmembrane transport
N6	0005739	cellular_component	mitochondrion
N6	0005743	cellular_component	mitochondrial inner membrane
N6	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
N6	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N6	0022904	biological_process	respiratory electron transport chain
N6	0032981	biological_process	mitochondrial respiratory chain complex I assembly
N6	0045271	cellular_component	respiratory chain complex I
N6	1902600	biological_process	proton transmembrane transport
S1	0005743	cellular_component	mitochondrial inner membrane
S1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S1	0016491	molecular_function	oxidoreductase activity
S1	0022904	biological_process	respiratory electron transport chain
S1	0032981	biological_process	mitochondrial respiratory chain complex I assembly
S1	0045271	cellular_component	respiratory chain complex I
S1	0046872	molecular_function	metal ion binding
S1	0051536	molecular_function	iron-sulfur cluster binding
S1	0051537	molecular_function	2 iron, 2 sulfur cluster binding
S1	0051539	molecular_function	4 iron, 4 sulfur cluster binding
S1	1902600	biological_process	proton transmembrane transport
S2	0003954	molecular_function	NADH dehydrogenase activity
S2	0005739	cellular_component	mitochondrion
S2	0005743	cellular_component	mitochondrial inner membrane
S2	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S2	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S2	0019826	molecular_function	oxygen sensor activity
S2	0022008	biological_process	neurogenesis
S2	0031625	molecular_function	ubiquitin protein ligase binding
S2	0032981	biological_process	mitochondrial respiratory chain complex I assembly
S2	0042063	biological_process	gliogenesis
S2	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
S2	0045271	cellular_component	respiratory chain complex I
S2	0046872	molecular_function	metal ion binding
S2	0051536	molecular_function	iron-sulfur cluster binding
S2	0051539	molecular_function	4 iron, 4 sulfur cluster binding
S2	0061351	biological_process	neural precursor cell proliferation
S2	0071453	biological_process	cellular response to oxygen levels
S2	1902600	biological_process	proton transmembrane transport
S5	0005739	cellular_component	mitochondrion
S5	0005743	cellular_component	mitochondrial inner membrane
S5	0005758	cellular_component	mitochondrial intermembrane space
S5	0022904	biological_process	respiratory electron transport chain
S5	0032981	biological_process	mitochondrial respiratory chain complex I assembly
S5	0045271	cellular_component	respiratory chain complex I
V1	0000166	molecular_function	nucleotide binding
V1	0005743	cellular_component	mitochondrial inner membrane
V1	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
V1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
V1	0022904	biological_process	respiratory electron transport chain
V1	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
V1	0045271	cellular_component	respiratory chain complex I
V1	0046872	molecular_function	metal ion binding
V1	0051287	molecular_function	NAD binding
V1	0051536	molecular_function	iron-sulfur cluster binding
V1	0051539	molecular_function	4 iron, 4 sulfur cluster binding
V1	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
AB	ASP107-MET122

---

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
AB	ASP132-ILE144

---

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP

Chain	Residue	Details
S8	CYS113-PRO124
S8	CYS152-PRO163

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
S2	LEU122-LYS133

---

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL

Chain	Residue	Details
S3	GLU167-LEU188

---

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
S1	PRO61-CYS78

---

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
S1	CYS128-GLN140

---

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF

Chain	Residue	Details
S1	ARG175-PHE185

---

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
V1	GLY200-SER215

---

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
V1	GLU377-GLY388

---

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpIaDALKLFtKE

Chain	Residue	Details
N1	GLY44-GLU59

---

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLTEGEseLVs.G

Chain	Residue	Details
N1	PRO197-GLY210

---

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP

Chain	Residue	Details
V2	ASP166-PRO184

---

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP

Chain	Residue	Details
S7	GLY152-PRO168

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	560
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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