8ZR5

Cryo-EM Structure of GPR119-Gs-Firuglipel complex

This is a non-PDB format compatible entry.

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVlTVMLITFDRYLaI

Chain	Residue	Details
C	ALA91-ILE107

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site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS

Chain	Residue	Details
B	LEU70-SER84
B	ILE157-ILE171
B	LEU285-ALA299
B	VAL327-VAL341

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
C	MET1-ALA12
C	SER59-ARG81
C	GLN147-HIS164
C	GLN248-ARG262
A	ASP223
A	ASN292
A	ALA366

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical; Name=1 => ECO:0000255

Chain	Residue	Details
C	VAL13-ILE33

---

site_id	SWS_FT_FI3
Number of Residues	116
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
C	HIS34-ASP37
C	ARG103-CYS125
C	CYS186-THR226
C	LYS284-GLY335

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	TRANSMEM: Helical; Name=2 => ECO:0000255

Chain	Residue	Details
C	GLY38-ILE58

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site_id	SWS_FT_FI5
Number of Residues	20
Details	TRANSMEM: Helical; Name=3 => ECO:0000255

Chain	Residue	Details
C	MET82-ASP102

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site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000255

Chain	Residue	Details
C	ILE126-PHE146

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site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=5 => ECO:0000255

Chain	Residue	Details
C	PHE165-TYR185

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site_id	SWS_FT_FI8
Number of Residues	20
Details	TRANSMEM: Helical; Name=6 => ECO:0000255

Chain	Residue	Details
C	VAL227-VAL247

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site_id	SWS_FT_FI9
Number of Residues	20
Details	TRANSMEM: Helical; Name=7 => ECO:0000255

Chain	Residue	Details
C	TYR263-GLN283

---