8ZP4

Cryo-EM structure of origin recognition complex (Orc1 to 5) with ARS1 DNA bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003688	molecular_function	DNA replication origin binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005656	cellular_component	nuclear pre-replicative complex
A	0005664	cellular_component	nuclear origin of replication recognition complex
A	0006260	biological_process	DNA replication
A	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
A	0006270	biological_process	DNA replication initiation
A	0016887	molecular_function	ATP hydrolysis activity
A	0030466	biological_process	silent mating-type cassette heterochromatin formation
A	0031261	cellular_component	DNA replication preinitiation complex
A	0031491	molecular_function	nucleosome binding
A	0033314	biological_process	mitotic DNA replication checkpoint signaling
A	0034728	biological_process	nucleosome organization
A	0043007	biological_process	maintenance of rDNA
A	0046872	molecular_function	metal ion binding
B	0000781	cellular_component	chromosome, telomeric region
B	0003682	molecular_function	chromatin binding
B	0003688	molecular_function	DNA replication origin binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005656	cellular_component	nuclear pre-replicative complex
B	0005664	cellular_component	nuclear origin of replication recognition complex
B	0006260	biological_process	DNA replication
B	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
B	0006270	biological_process	DNA replication initiation
B	0030466	biological_process	silent mating-type cassette heterochromatin formation
B	0031261	cellular_component	DNA replication preinitiation complex
B	0031509	biological_process	subtelomeric heterochromatin formation
C	0003677	molecular_function	DNA binding
C	0003682	molecular_function	chromatin binding
C	0003688	molecular_function	DNA replication origin binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005656	cellular_component	nuclear pre-replicative complex
C	0005664	cellular_component	nuclear origin of replication recognition complex
C	0006260	biological_process	DNA replication
C	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
C	0006270	biological_process	DNA replication initiation
C	0030466	biological_process	silent mating-type cassette heterochromatin formation
C	0031261	cellular_component	DNA replication preinitiation complex
D	0003677	molecular_function	DNA binding
D	0003688	molecular_function	DNA replication origin binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005656	cellular_component	nuclear pre-replicative complex
D	0005664	cellular_component	nuclear origin of replication recognition complex
D	0006260	biological_process	DNA replication
D	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
D	0006270	biological_process	DNA replication initiation
D	0030466	biological_process	silent mating-type cassette heterochromatin formation
D	0031261	cellular_component	DNA replication preinitiation complex
E	0000166	molecular_function	nucleotide binding
E	0003688	molecular_function	DNA replication origin binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005656	cellular_component	nuclear pre-replicative complex
E	0005664	cellular_component	nuclear origin of replication recognition complex
E	0006260	biological_process	DNA replication
E	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
E	0006270	biological_process	DNA replication initiation
E	0006275	biological_process	regulation of DNA replication
E	0030466	biological_process	silent mating-type cassette heterochromatin formation
E	0031261	cellular_component	DNA replication preinitiation complex
E	0035361	cellular_component	Cul8-RING ubiquitin ligase complex

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DLNQSKKMNvsEF

Chain	Residue	Details
C	ASP3-PHE15

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13415","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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