8ZKO
CryoEM structure of Thyroid Hormone Transporter MCT8
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006590 | biological_process | thyroid hormone generation |
| A | 0008028 | molecular_function | monocarboxylic acid transmembrane transporter activity |
| A | 0015171 | molecular_function | amino acid transmembrane transporter activity |
| A | 0015349 | molecular_function | thyroid hormone transmembrane transporter activity |
| A | 0015718 | biological_process | monocarboxylic acid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0042403 | biological_process | thyroid hormone metabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046943 | molecular_function | carboxylic acid transmembrane transporter activity |
| A | 0070327 | biological_process | thyroid hormone transport |
| A | 0070460 | biological_process | thyroid-stimulating hormone secretion |
| A | 0089718 | biological_process | amino acid import across plasma membrane |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1905039 | biological_process | carboxylic acid transmembrane transport |
| A | 2000178 | biological_process | negative regulation of neural precursor cell proliferation |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006590 | biological_process | thyroid hormone generation |
| B | 0008028 | molecular_function | monocarboxylic acid transmembrane transporter activity |
| B | 0015171 | molecular_function | amino acid transmembrane transporter activity |
| B | 0015349 | molecular_function | thyroid hormone transmembrane transporter activity |
| B | 0015718 | biological_process | monocarboxylic acid transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0042403 | biological_process | thyroid hormone metabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046943 | molecular_function | carboxylic acid transmembrane transporter activity |
| B | 0070327 | biological_process | thyroid hormone transport |
| B | 0070460 | biological_process | thyroid-stimulating hormone secretion |
| B | 0089718 | biological_process | amino acid import across plasma membrane |
| B | 0150104 | biological_process | transport across blood-brain barrier |
| B | 1905039 | biological_process | carboxylic acid transmembrane transport |
| B | 2000178 | biological_process | negative regulation of neural precursor cell proliferation |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 74 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 70 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=10","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=11","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=12","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
