Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8ZJJ

Structure of DOCK5/ELMO1/Rac1 core (RhoG/DOCK5/ELMO1/Rac1 dataset, class 2)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006909biological_processphagocytosis
A0006911biological_processphagocytosis, engulfment
A0006915biological_processapoptotic process
A0007015biological_processactin filament organization
A0016020cellular_componentmembrane
A0016601biological_processRac protein signal transduction
A0017124molecular_functionSH3 domain binding
A0030029biological_processactin filament-based process
A0030036biological_processactin cytoskeleton organization
A0032045cellular_componentguanyl-nucleotide exchange factor complex
A0048870biological_processcell motility
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0150052biological_processregulation of postsynapse assembly
C0001764biological_processneuron migration
C0001934biological_processpositive regulation of protein phosphorylation
C0003376biological_processsphingosine-1-phosphate receptor signaling pathway
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005802cellular_componenttrans-Golgi network
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005884cellular_componentactin filament
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0005938cellular_componentcell cortex
C0006954biological_processinflammatory response
C0007015biological_processactin filament organization
C0007155biological_processcell adhesion
C0007160biological_processcell-matrix adhesion
C0007163biological_processestablishment or maintenance of cell polarity
C0007264biological_processsmall GTPase-mediated signal transduction
C0008045biological_processmotor neuron axon guidance
C0008360biological_processregulation of cell shape
C0008361biological_processregulation of cell size
C0009611biological_processresponse to wounding
C0009653biological_processanatomical structure morphogenesis
C0010310biological_processregulation of hydrogen peroxide metabolic process
C0010591biological_processregulation of lamellipodium assembly
C0010592biological_processpositive regulation of lamellipodium assembly
C0010595biological_processpositive regulation of endothelial cell migration
C0010764biological_processnegative regulation of fibroblast migration
C0010811biological_processpositive regulation of cell-substrate adhesion
C0016020cellular_componentmembrane
C0016477biological_processcell migration
C0016601biological_processRac protein signal transduction
C0016787molecular_functionhydrolase activity
C0019899molecular_functionenzyme binding
C0019901molecular_functionprotein kinase binding
C0030027cellular_componentlamellipodium
C0030031biological_processcell projection assembly
C0030032biological_processlamellipodium assembly
C0030036biological_processactin cytoskeleton organization
C0030041biological_processactin filament polymerization
C0030334biological_processregulation of cell migration
C0030425cellular_componentdendrite
C0030667cellular_componentsecretory granule membrane
C0030865biological_processcortical cytoskeleton organization
C0031116biological_processpositive regulation of microtubule polymerization
C0031410cellular_componentcytoplasmic vesicle
C0031529biological_processruffle organization
C0031996molecular_functionthioesterase binding
C0032587cellular_componentruffle membrane
C0032707biological_processnegative regulation of interleukin-23 production
C0032956biological_processregulation of actin cytoskeleton organization
C0034446biological_processsubstrate adhesion-dependent cell spreading
C0035025biological_processpositive regulation of Rho protein signal transduction
C0035556biological_processintracellular signal transduction
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0042470cellular_componentmelanosome
C0042995cellular_componentcell projection
C0043020cellular_componentNADPH oxidase complex
C0043197cellular_componentdendritic spine
C0043652biological_processengulfment of apoptotic cell
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0045428biological_processregulation of nitric oxide biosynthetic process
C0045730biological_processrespiratory burst
C0048012biological_processhepatocyte growth factor receptor signaling pathway
C0048261biological_processnegative regulation of receptor-mediated endocytosis
C0048870biological_processcell motility
C0051022molecular_functionRho GDP-dissociation inhibitor binding
C0051492biological_processregulation of stress fiber assembly
C0051496biological_processpositive regulation of stress fiber assembly
C0051668biological_processlocalization within membrane
C0051894biological_processpositive regulation of focal adhesion assembly
C0055038cellular_componentrecycling endosome membrane
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0060263biological_processregulation of respiratory burst
C0060326biological_processcell chemotaxis
C0070062cellular_componentextracellular exosome
C0071526biological_processsemaphorin-plexin signaling pathway
C0090023biological_processpositive regulation of neutrophil chemotaxis
C0097178biological_processruffle assembly
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0101003cellular_componentficolin-1-rich granule membrane
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
C1902622biological_processregulation of neutrophil migration
D0005085molecular_functionguanyl-nucleotide exchange factor activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006909biological_processphagocytosis
D0006911biological_processphagocytosis, engulfment
D0006915biological_processapoptotic process
D0007015biological_processactin filament organization
D0016020cellular_componentmembrane
D0016601biological_processRac protein signal transduction
D0017124molecular_functionSH3 domain binding
D0030029biological_processactin filament-based process
D0030036biological_processactin cytoskeleton organization
D0032045cellular_componentguanyl-nucleotide exchange factor complex
D0048870biological_processcell motility
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0150052biological_processregulation of postsynapse assembly
F0001764biological_processneuron migration
F0001934biological_processpositive regulation of protein phosphorylation
F0003376biological_processsphingosine-1-phosphate receptor signaling pathway
F0003924molecular_functionGTPase activity
F0003925molecular_functionG protein activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005789cellular_componentendoplasmic reticulum membrane
F0005802cellular_componenttrans-Golgi network
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005884cellular_componentactin filament
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0005938cellular_componentcell cortex
F0006954biological_processinflammatory response
F0007015biological_processactin filament organization
F0007155biological_processcell adhesion
F0007160biological_processcell-matrix adhesion
F0007163biological_processestablishment or maintenance of cell polarity
F0007264biological_processsmall GTPase-mediated signal transduction
F0008045biological_processmotor neuron axon guidance
F0008360biological_processregulation of cell shape
F0008361biological_processregulation of cell size
F0009611biological_processresponse to wounding
F0009653biological_processanatomical structure morphogenesis
F0010310biological_processregulation of hydrogen peroxide metabolic process
F0010591biological_processregulation of lamellipodium assembly
F0010592biological_processpositive regulation of lamellipodium assembly
F0010595biological_processpositive regulation of endothelial cell migration
F0010764biological_processnegative regulation of fibroblast migration
F0010811biological_processpositive regulation of cell-substrate adhesion
F0016020cellular_componentmembrane
F0016477biological_processcell migration
F0016601biological_processRac protein signal transduction
F0016787molecular_functionhydrolase activity
F0019899molecular_functionenzyme binding
F0019901molecular_functionprotein kinase binding
F0030027cellular_componentlamellipodium
F0030031biological_processcell projection assembly
F0030032biological_processlamellipodium assembly
F0030036biological_processactin cytoskeleton organization
F0030041biological_processactin filament polymerization
F0030334biological_processregulation of cell migration
F0030425cellular_componentdendrite
F0030667cellular_componentsecretory granule membrane
F0030865biological_processcortical cytoskeleton organization
F0031116biological_processpositive regulation of microtubule polymerization
F0031410cellular_componentcytoplasmic vesicle
F0031529biological_processruffle organization
F0031996molecular_functionthioesterase binding
F0032587cellular_componentruffle membrane
F0032707biological_processnegative regulation of interleukin-23 production
F0032956biological_processregulation of actin cytoskeleton organization
F0034446biological_processsubstrate adhesion-dependent cell spreading
F0035025biological_processpositive regulation of Rho protein signal transduction
F0035556biological_processintracellular signal transduction
F0036464cellular_componentcytoplasmic ribonucleoprotein granule
F0042470cellular_componentmelanosome
F0042995cellular_componentcell projection
F0043020cellular_componentNADPH oxidase complex
F0043197cellular_componentdendritic spine
F0043652biological_processengulfment of apoptotic cell
F0044877molecular_functionprotein-containing complex binding
F0045202cellular_componentsynapse
F0045428biological_processregulation of nitric oxide biosynthetic process
F0045730biological_processrespiratory burst
F0048012biological_processhepatocyte growth factor receptor signaling pathway
F0048261biological_processnegative regulation of receptor-mediated endocytosis
F0048870biological_processcell motility
F0051022molecular_functionRho GDP-dissociation inhibitor binding
F0051492biological_processregulation of stress fiber assembly
F0051496biological_processpositive regulation of stress fiber assembly
F0051668biological_processlocalization within membrane
F0051894biological_processpositive regulation of focal adhesion assembly
F0055038cellular_componentrecycling endosome membrane
F0060071biological_processWnt signaling pathway, planar cell polarity pathway
F0060263biological_processregulation of respiratory burst
F0060326biological_processcell chemotaxis
F0070062cellular_componentextracellular exosome
F0071526biological_processsemaphorin-plexin signaling pathway
F0090023biological_processpositive regulation of neutrophil chemotaxis
F0097178biological_processruffle assembly
F0098794cellular_componentpostsynapse
F0098978cellular_componentglutamatergic synapse
F0101003cellular_componentficolin-1-rich granule membrane
F1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
F1902622biological_processregulation of neutrophil migration
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR
ChainResidueDetails
CALA13
DTYR720
CGLY30
CGLY60
FALA13
FGLY30
FGLY60
DTYR216
DTYR395
DTYR511

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR, ECO:0007744|PDB:5HZH
ChainResidueDetails
CLYS116
CALA159
FLYS116
FALA159

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
ChainResidueDetails
CTYR32
FTYR32

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
CTHR35
FTHR35

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10617634
ChainResidueDetails
CSER71
FSER71

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
CTYR32
FTYR32

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB, and by P.sordellii toxin TcsL; alternate => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
CTHR35
FTHR35

site_idSWS_FT_FI8
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18093184
ChainResidueDetails
CLYS147
FLYS147

site_idSWS_FT_FI9
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23512198
ChainResidueDetails
CLYS166
FLYS166

223790

PDB entries from 2024-08-14

PDB statisticsPDBj update infoContact PDBjnumon