8ZI9
Human left ventricle actin and myosin complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| F | 0000146 | molecular_function | microfilament motor activity |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0005200 | molecular_function | structural constituent of cytoskeleton |
| F | 0005515 | molecular_function | protein binding |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005615 | cellular_component | extracellular space |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0005856 | cellular_component | cytoskeleton |
| F | 0005884 | cellular_component | actin filament |
| F | 0005925 | cellular_component | focal adhesion |
| F | 0007015 | biological_process | actin filament organization |
| F | 0009410 | biological_process | response to xenobiotic stimulus |
| F | 0010628 | biological_process | positive regulation of gene expression |
| F | 0015629 | cellular_component | actin cytoskeleton |
| F | 0016020 | cellular_component | membrane |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0017022 | molecular_function | myosin binding |
| F | 0030017 | cellular_component | sarcomere |
| F | 0030027 | cellular_component | lamellipodium |
| F | 0030048 | biological_process | actin filament-based movement |
| F | 0030175 | cellular_component | filopodium |
| F | 0030240 | biological_process | skeletal muscle thin filament assembly |
| F | 0031032 | biological_process | actomyosin structure organization |
| F | 0031674 | cellular_component | I band |
| F | 0033275 | biological_process | actin-myosin filament sliding |
| F | 0044297 | cellular_component | cell body |
| F | 0045202 | cellular_component | synapse |
| F | 0045471 | biological_process | response to ethanol |
| F | 0055003 | biological_process | cardiac myofibril assembly |
| F | 0055008 | biological_process | cardiac muscle tissue morphogenesis |
| F | 0060047 | biological_process | heart contraction |
| F | 0060048 | biological_process | cardiac muscle contraction |
| F | 0070062 | cellular_component | extracellular exosome |
| F | 0072562 | cellular_component | blood microparticle |
| F | 0090131 | biological_process | mesenchyme migration |
| F | 0098978 | cellular_component | glutamatergic synapse |
| M | 0003774 | molecular_function | cytoskeletal motor activity |
| M | 0005524 | molecular_function | ATP binding |
| M | 0016459 | cellular_component | myosin complex |
| M | 0051015 | molecular_function | actin filament binding |
Functional Information from PROSITE/UniProt
| site_id | PS00406 |
| Number of Residues | 11 |
| Details | ACTINS_1 Actins signature 1. YVGDEAQs.KRG |
| Chain | Residue | Details |
| F | TYR53-GLY63 |
| site_id | PS00432 |
| Number of Residues | 9 |
| Details | ACTINS_2 Actins signature 2. WISKqEYDE |
| Chain | Residue | Details |
| F | TRP356-GLU364 |
| site_id | PS01132 |
| Number of Residues | 13 |
| Details | ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR |
| Chain | Residue | Details |
| F | LEU104-ARG116 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 49 |
| Details | Domain: {"description":"Myosin N-terminal SH3-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01190","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Region: {"description":"Actin-binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P02563","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P68033","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"23673617","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"Isoglutamyl lysine isopeptide (Lys-Glu) (interchain with E-272); by Vibrio toxins RtxA and VgrG1","evidences":[{"source":"UniProtKB","id":"P60709","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-52); by Vibrio toxins RtxA and VgrG1","evidences":[{"source":"UniProtKB","id":"P60709","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
