8ZD5

Crystal structure of E40K variant of Cu/Zn-superoxide dismutase from dog (Canis familiaris) in the holo form complexed with 22E1 Fv-clasp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004784	molecular_function	superoxide dismutase activity
A	0005507	molecular_function	copper ion binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005777	cellular_component	peroxisome
A	0005829	cellular_component	cytosol
A	0006801	biological_process	superoxide metabolic process
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0019430	biological_process	removal of superoxide radicals
A	0046872	molecular_function	metal ion binding
A	0072593	biological_process	reactive oxygen species metabolic process
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0007165	biological_process	signal transduction
B	0051262	biological_process	protein tetramerization
C	0002250	biological_process	adaptive immune response
C	0002376	biological_process	immune system process
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005576	cellular_component	extracellular region
C	0005886	cellular_component	plasma membrane
C	0006955	biological_process	immune response
C	0007165	biological_process	signal transduction
C	0019814	cellular_component	immunoglobulin complex
C	0051262	biological_process	protein tetramerization
D	0004784	molecular_function	superoxide dismutase activity
D	0005507	molecular_function	copper ion binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005777	cellular_component	peroxisome
D	0005829	cellular_component	cytosol
D	0006801	biological_process	superoxide metabolic process
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0019430	biological_process	removal of superoxide radicals
D	0046872	molecular_function	metal ion binding
D	0072593	biological_process	reactive oxygen species metabolic process
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0007165	biological_process	signal transduction
E	0051262	biological_process	protein tetramerization
F	0002250	biological_process	adaptive immune response
F	0002376	biological_process	immune system process
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0005576	cellular_component	extracellular region
F	0005886	cellular_component	plasma membrane
F	0006955	biological_process	immune response
F	0007165	biological_process	signal transduction
F	0019814	cellular_component	immunoglobulin complex
F	0051262	biological_process	protein tetramerization
G	0004784	molecular_function	superoxide dismutase activity
G	0005507	molecular_function	copper ion binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005777	cellular_component	peroxisome
G	0005829	cellular_component	cytosol
G	0006801	biological_process	superoxide metabolic process
G	0016209	molecular_function	antioxidant activity
G	0016491	molecular_function	oxidoreductase activity
G	0019430	biological_process	removal of superoxide radicals
G	0046872	molecular_function	metal ion binding
G	0072593	biological_process	reactive oxygen species metabolic process
H	0004674	molecular_function	protein serine/threonine kinase activity
H	0007165	biological_process	signal transduction
H	0051262	biological_process	protein tetramerization
I	0002250	biological_process	adaptive immune response
I	0002376	biological_process	immune system process
I	0004674	molecular_function	protein serine/threonine kinase activity
I	0005576	cellular_component	extracellular region
I	0005886	cellular_component	plasma membrane
I	0006955	biological_process	immune response
I	0007165	biological_process	signal transduction
I	0019814	cellular_component	immunoglobulin complex
I	0051262	biological_process	protein tetramerization
J	0004784	molecular_function	superoxide dismutase activity
J	0005507	molecular_function	copper ion binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005777	cellular_component	peroxisome
J	0005829	cellular_component	cytosol
J	0006801	biological_process	superoxide metabolic process
J	0016209	molecular_function	antioxidant activity
J	0016491	molecular_function	oxidoreductase activity
J	0019430	biological_process	removal of superoxide radicals
J	0046872	molecular_function	metal ion binding
J	0072593	biological_process	reactive oxygen species metabolic process
K	0004674	molecular_function	protein serine/threonine kinase activity
K	0007165	biological_process	signal transduction
K	0051262	biological_process	protein tetramerization
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0004674	molecular_function	protein serine/threonine kinase activity
L	0005576	cellular_component	extracellular region
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0007165	biological_process	signal transduction
L	0019814	cellular_component	immunoglobulin complex
L	0051262	biological_process	protein tetramerization

Functional Information from PROSITE/UniProt

site_id	PS00087
Number of Residues	11
Details	SOD_CU_ZN_1 Copper/Zinc superoxide dismutase signature 1. GFHVHQfGDnT

Chain	Residue	Details
A	GLY44-THR54

---

site_id	PS00332
Number of Residues	12
Details	SOD_CU_ZN_2 Copper/Zinc superoxide dismutase signature 2. GNAGsRlACgvI

Chain	Residue	Details
A	GLY138-ILE149

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P00441","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P00441","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---