8ZC4
SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with 3 D1F6 Fabs (2 RBD up)
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH |
| Chain | Residue | Details |
| G | TYR202-HIS208 | |
| H | TYR208-HIS214 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| A | ALA694 | |
| B | ALA694 | |
| C | ALA694 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| A | ASN824 | |
| B | ASN824 | |
| C | ASN824 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | ASN20 | |
| A | GLY1167 | |
| A | GLU1182 | |
| B | ASN20 | |
| B | GLY1167 | |
| B | GLU1182 | |
| C | ASN20 | |
| C | GLY1167 | |
| C | GLU1182 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 15 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | TRP64 | |
| B | HIS1083 | |
| C | TRP64 | |
| C | VAL127 | |
| C | ILE726 | |
| C | SER810 | |
| C | HIS1083 | |
| A | VAL127 | |
| A | ILE726 | |
| A | SER810 | |
| A | HIS1083 | |
| B | TRP64 | |
| B | VAL127 | |
| B | ILE726 | |
| B | SER810 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | PHE79 | |
| A | GLU154 | |
| A | LEU1203 | |
| B | PHE79 | |
| B | GLU154 | |
| B | LEU1203 | |
| C | PHE79 | |
| C | GLU154 | |
| C | LEU1203 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | TYR170 | |
| B | CYS336 | |
| B | ALA348 | |
| B | PRO621 | |
| B | CYS662 | |
| B | ARG1107 | |
| C | TYR170 | |
| C | ASP287 | |
| C | CYS336 | |
| C | ALA348 | |
| C | PRO621 | |
| A | ASP287 | |
| C | CYS662 | |
| C | ARG1107 | |
| A | CYS336 | |
| A | ALA348 | |
| A | PRO621 | |
| A | CYS662 | |
| A | ARG1107 | |
| B | TYR170 | |
| B | ASP287 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | GLN239 | |
| A | PHE718 | |
| B | GLN239 | |
| B | PHE718 | |
| C | GLN239 | |
| C | PHE718 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| A | ARG328 | |
| B | ARG328 | |
| C | ARG328 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| A | PRO330 | |
| B | PRO330 | |
| C | PRO330 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | VAL608 | |
| B | VAL608 | |
| C | VAL608 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583 |
| Chain | Residue | Details |
| A | ARG685 | |
| A | VAL687 | |
| B | ARG685 | |
| B | VAL687 | |
| C | ARG685 | |
| C | VAL687 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | PRO1143 | |
| B | PRO1143 | |
| C | PRO1143 |
