8ZC2

SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with D1F6 Fab, head-to-head aggregate

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH

Chain	Residue	Details
G	TYR202-HIS208
H	TYR208-HIS214

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616

Chain	Residue	Details
A	ILE692
B	ILE692
C	ILE692
D	ILE692
E	ILE692
F	ILE692

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site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616

Chain	Residue	Details
A	LEU822
B	LEU822
C	LEU822
D	LEU822
E	LEU822
F	LEU822

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site_id	SWS_FT_FI3
Number of Residues	18
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
A	ASN20
D	ASN20
D	ASP1165
D	GLN1180
E	ASN20
E	ASP1165
E	GLN1180
F	ASN20
F	ASP1165
F	GLN1180
A	ASP1165
A	GLN1180
B	ASN20
B	ASP1165
B	GLN1180
C	ASN20
C	ASP1165
C	GLN1180

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site_id	SWS_FT_FI4
Number of Residues	30
Details	CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
A	TRP64
B	ILE1081
C	TRP64
C	ASN125
C	THR724
C	ASP808
C	ILE1081
D	TRP64
D	ASN125
D	THR724
D	ASP808
A	ASN125
D	ILE1081
E	TRP64
E	ASN125
E	THR724
E	ASP808
E	ILE1081
F	TRP64
F	ASN125
F	THR724
F	ASP808
A	THR724
F	ILE1081
A	ASP808
A	ILE1081
B	TRP64
B	ASN125
B	THR724
B	ASP808

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site_id	SWS_FT_FI5
Number of Residues	18
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
A	LYS77
D	LYS77
D	TRP152
D	GLN1201
E	LYS77
E	TRP152
E	GLN1201
F	LYS77
F	TRP152
F	GLN1201
A	TRP152
A	GLN1201
B	LYS77
B	TRP152
B	GLN1201
C	LYS77
C	TRP152
C	GLN1201

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site_id	SWS_FT_FI6
Number of Residues	42
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
A	PHE168
B	ASN334
B	ARG346
B	GLU619
B	TYR660
B	THR1105
C	PHE168
C	ILE285
C	ASN334
C	ARG346
C	GLU619
A	ILE285
C	TYR660
C	THR1105
D	PHE168
D	ILE285
D	ASN334
D	ARG346
D	GLU619
D	TYR660
D	THR1105
E	PHE168
A	ASN334
E	ILE285
E	ASN334
E	ARG346
E	GLU619
E	TYR660
E	THR1105
F	PHE168
F	ILE285
F	ASN334
F	ARG346
A	ARG346
F	GLU619
F	TYR660
F	THR1105
A	GLU619
A	TYR660
A	THR1105
B	PHE168
B	ILE285

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site_id	SWS_FT_FI7
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
A	ARG237
E	THR716
F	ARG237
F	THR716
A	THR716
B	ARG237
B	THR716
C	ARG237
C	THR716
D	ARG237
D	THR716
E	ARG237

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site_id	SWS_FT_FI8
Number of Residues	6
Details	CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391

Chain	Residue	Details
A	ILE326
B	ILE326
C	ILE326
D	ILE326
E	ILE326
F	ILE326

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site_id	SWS_FT_FI9
Number of Residues	6
Details	CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391

Chain	Residue	Details
A	ARG328
B	ARG328
C	ARG328
D	ARG328
E	ARG328
F	ARG328

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site_id	SWS_FT_FI10
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
A	ASN606
B	ASN606
C	ASN606
D	ASN606
E	ASN606
F	ASN606

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site_id	SWS_FT_FI11
Number of Residues	12
Details	CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583

Chain	Residue	Details
A	LYS683
E	ARG685
F	LYS683
F	ARG685
A	ARG685
B	LYS683
B	ARG685
C	LYS683
C	ARG685
D	LYS683
D	ARG685
E	LYS683

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site_id	SWS_FT_FI12
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
A	LEU1141
B	LEU1141
C	LEU1141
D	LEU1141
E	LEU1141
F	LEU1141

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