8ZBZ
SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with 3 D1F6 Fabs (1 RBD up)
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH |
| Chain | Residue | Details |
| D | TYR202-HIS208 | |
| E | TYR208-HIS214 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| A | ILE692 | |
| B | ILE692 | |
| C | ILE692 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| A | LEU822 | |
| B | LEU822 | |
| C | LEU822 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | ASN20 | |
| A | ASP1165 | |
| A | GLN1180 | |
| B | ASN20 | |
| B | ASP1165 | |
| B | GLN1180 | |
| C | ASN20 | |
| C | ASP1165 | |
| C | GLN1180 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 15 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | TRP64 | |
| B | ILE1081 | |
| C | TRP64 | |
| C | ASN125 | |
| C | THR724 | |
| C | ASP808 | |
| C | ILE1081 | |
| A | ASN125 | |
| A | THR724 | |
| A | ASP808 | |
| A | ILE1081 | |
| B | TRP64 | |
| B | ASN125 | |
| B | THR724 | |
| B | ASP808 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | LYS77 | |
| A | TRP152 | |
| A | GLN1201 | |
| B | LYS77 | |
| B | TRP152 | |
| B | GLN1201 | |
| C | LYS77 | |
| C | TRP152 | |
| C | GLN1201 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | PHE168 | |
| B | ASN334 | |
| B | ARG346 | |
| B | GLU619 | |
| B | TYR660 | |
| B | THR1105 | |
| C | PHE168 | |
| C | ILE285 | |
| C | ASN334 | |
| C | ARG346 | |
| C | GLU619 | |
| A | ILE285 | |
| C | TYR660 | |
| C | THR1105 | |
| A | ASN334 | |
| A | ARG346 | |
| A | GLU619 | |
| A | TYR660 | |
| A | THR1105 | |
| B | PHE168 | |
| B | ILE285 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | ARG237 | |
| A | THR716 | |
| B | ARG237 | |
| B | THR716 | |
| C | ARG237 | |
| C | THR716 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| A | ILE326 | |
| B | ILE326 | |
| C | ILE326 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| A | ARG328 | |
| B | ARG328 | |
| C | ARG328 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | ASN606 | |
| B | ASN606 | |
| C | ASN606 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583 |
| Chain | Residue | Details |
| A | LYS683 | |
| A | ARG685 | |
| B | LYS683 | |
| B | ARG685 | |
| C | LYS683 | |
| C | ARG685 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | LEU1141 | |
| B | LEU1141 | |
| C | LEU1141 |
