8ZBN

Mouse MYH6 R404Q left ventricle ATM complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003774	molecular_function	cytoskeletal motor activity
A	0005524	molecular_function	ATP binding
A	0016459	cellular_component	myosin complex
A	0051015	molecular_function	actin filament binding
B	0000146	molecular_function	microfilament motor activity
B	0000166	molecular_function	nucleotide binding
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005884	cellular_component	actin filament
B	0007015	biological_process	actin filament organization
B	0009410	biological_process	response to xenobiotic stimulus
B	0010628	biological_process	positive regulation of gene expression
B	0015629	cellular_component	actin cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0017022	molecular_function	myosin binding
B	0030017	cellular_component	sarcomere
B	0030027	cellular_component	lamellipodium
B	0030048	biological_process	actin filament-based movement
B	0030175	cellular_component	filopodium
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0031032	biological_process	actomyosin structure organization
B	0031674	cellular_component	I band
B	0033275	biological_process	actin-myosin filament sliding
B	0043066	biological_process	negative regulation of apoptotic process
B	0044297	cellular_component	cell body
B	0045202	cellular_component	synapse
B	0045471	biological_process	response to ethanol
B	0055003	biological_process	cardiac myofibril assembly
B	0055008	biological_process	cardiac muscle tissue morphogenesis
B	0060047	biological_process	heart contraction
B	0060048	biological_process	cardiac muscle contraction
B	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
B	0090131	biological_process	mesenchyme migration
B	0098978	cellular_component	glutamatergic synapse
C	0003774	molecular_function	cytoskeletal motor activity
C	0005524	molecular_function	ATP binding
C	0016459	cellular_component	myosin complex
C	0051015	molecular_function	actin filament binding
D	0000146	molecular_function	microfilament motor activity
D	0000166	molecular_function	nucleotide binding
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005884	cellular_component	actin filament
D	0007015	biological_process	actin filament organization
D	0009410	biological_process	response to xenobiotic stimulus
D	0010628	biological_process	positive regulation of gene expression
D	0015629	cellular_component	actin cytoskeleton
D	0016787	molecular_function	hydrolase activity
D	0017022	molecular_function	myosin binding
D	0030017	cellular_component	sarcomere
D	0030027	cellular_component	lamellipodium
D	0030048	biological_process	actin filament-based movement
D	0030175	cellular_component	filopodium
D	0030240	biological_process	skeletal muscle thin filament assembly
D	0031032	biological_process	actomyosin structure organization
D	0031674	cellular_component	I band
D	0033275	biological_process	actin-myosin filament sliding
D	0043066	biological_process	negative regulation of apoptotic process
D	0044297	cellular_component	cell body
D	0045202	cellular_component	synapse
D	0045471	biological_process	response to ethanol
D	0055003	biological_process	cardiac myofibril assembly
D	0055008	biological_process	cardiac muscle tissue morphogenesis
D	0060047	biological_process	heart contraction
D	0060048	biological_process	cardiac muscle contraction
D	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
D	0090131	biological_process	mesenchyme migration
D	0098978	cellular_component	glutamatergic synapse
F	0003774	molecular_function	cytoskeletal motor activity
F	0005524	molecular_function	ATP binding
F	0016459	cellular_component	myosin complex
F	0051015	molecular_function	actin filament binding
G	0003774	molecular_function	cytoskeletal motor activity
G	0005524	molecular_function	ATP binding
G	0016459	cellular_component	myosin complex
G	0051015	molecular_function	actin filament binding
H	0003774	molecular_function	cytoskeletal motor activity
H	0005524	molecular_function	ATP binding
H	0016459	cellular_component	myosin complex
H	0051015	molecular_function	actin filament binding
I	0000146	molecular_function	microfilament motor activity
I	0000166	molecular_function	nucleotide binding
I	0005200	molecular_function	structural constituent of cytoskeleton
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005884	cellular_component	actin filament
I	0007015	biological_process	actin filament organization
I	0009410	biological_process	response to xenobiotic stimulus
I	0010628	biological_process	positive regulation of gene expression
I	0015629	cellular_component	actin cytoskeleton
I	0016787	molecular_function	hydrolase activity
I	0017022	molecular_function	myosin binding
I	0030017	cellular_component	sarcomere
I	0030027	cellular_component	lamellipodium
I	0030048	biological_process	actin filament-based movement
I	0030175	cellular_component	filopodium
I	0030240	biological_process	skeletal muscle thin filament assembly
I	0031032	biological_process	actomyosin structure organization
I	0031674	cellular_component	I band
I	0033275	biological_process	actin-myosin filament sliding
I	0043066	biological_process	negative regulation of apoptotic process
I	0044297	cellular_component	cell body
I	0045202	cellular_component	synapse
I	0045471	biological_process	response to ethanol
I	0055003	biological_process	cardiac myofibril assembly
I	0055008	biological_process	cardiac muscle tissue morphogenesis
I	0060047	biological_process	heart contraction
I	0060048	biological_process	cardiac muscle contraction
I	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
I	0090131	biological_process	mesenchyme migration
I	0098978	cellular_component	glutamatergic synapse
J	0000146	molecular_function	microfilament motor activity
J	0000166	molecular_function	nucleotide binding
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005884	cellular_component	actin filament
J	0007015	biological_process	actin filament organization
J	0009410	biological_process	response to xenobiotic stimulus
J	0010628	biological_process	positive regulation of gene expression
J	0015629	cellular_component	actin cytoskeleton
J	0016787	molecular_function	hydrolase activity
J	0017022	molecular_function	myosin binding
J	0030017	cellular_component	sarcomere
J	0030027	cellular_component	lamellipodium
J	0030048	biological_process	actin filament-based movement
J	0030175	cellular_component	filopodium
J	0030240	biological_process	skeletal muscle thin filament assembly
J	0031032	biological_process	actomyosin structure organization
J	0031674	cellular_component	I band
J	0033275	biological_process	actin-myosin filament sliding
J	0043066	biological_process	negative regulation of apoptotic process
J	0044297	cellular_component	cell body
J	0045202	cellular_component	synapse
J	0045471	biological_process	response to ethanol
J	0055003	biological_process	cardiac myofibril assembly
J	0055008	biological_process	cardiac muscle tissue morphogenesis
J	0060047	biological_process	heart contraction
J	0060048	biological_process	cardiac muscle contraction
J	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
J	0090131	biological_process	mesenchyme migration
J	0098978	cellular_component	glutamatergic synapse
K	0000146	molecular_function	microfilament motor activity
K	0000166	molecular_function	nucleotide binding
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005884	cellular_component	actin filament
K	0007015	biological_process	actin filament organization
K	0009410	biological_process	response to xenobiotic stimulus
K	0010628	biological_process	positive regulation of gene expression
K	0015629	cellular_component	actin cytoskeleton
K	0016787	molecular_function	hydrolase activity
K	0017022	molecular_function	myosin binding
K	0030017	cellular_component	sarcomere
K	0030027	cellular_component	lamellipodium
K	0030048	biological_process	actin filament-based movement
K	0030175	cellular_component	filopodium
K	0030240	biological_process	skeletal muscle thin filament assembly
K	0031032	biological_process	actomyosin structure organization
K	0031674	cellular_component	I band
K	0033275	biological_process	actin-myosin filament sliding
K	0043066	biological_process	negative regulation of apoptotic process
K	0044297	cellular_component	cell body
K	0045202	cellular_component	synapse
K	0045471	biological_process	response to ethanol
K	0055003	biological_process	cardiac myofibril assembly
K	0055008	biological_process	cardiac muscle tissue morphogenesis
K	0060047	biological_process	heart contraction
K	0060048	biological_process	cardiac muscle contraction
K	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
K	0090131	biological_process	mesenchyme migration
K	0098978	cellular_component	glutamatergic synapse
L	0003774	molecular_function	cytoskeletal motor activity
L	0005524	molecular_function	ATP binding
L	0016459	cellular_component	myosin complex
L	0051015	molecular_function	actin filament binding
M	0000146	molecular_function	microfilament motor activity
M	0000166	molecular_function	nucleotide binding
M	0005200	molecular_function	structural constituent of cytoskeleton
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005884	cellular_component	actin filament
M	0007015	biological_process	actin filament organization
M	0009410	biological_process	response to xenobiotic stimulus
M	0010628	biological_process	positive regulation of gene expression
M	0015629	cellular_component	actin cytoskeleton
M	0016787	molecular_function	hydrolase activity
M	0017022	molecular_function	myosin binding
M	0030017	cellular_component	sarcomere
M	0030027	cellular_component	lamellipodium
M	0030048	biological_process	actin filament-based movement
M	0030175	cellular_component	filopodium
M	0030240	biological_process	skeletal muscle thin filament assembly
M	0031032	biological_process	actomyosin structure organization
M	0031674	cellular_component	I band
M	0033275	biological_process	actin-myosin filament sliding
M	0043066	biological_process	negative regulation of apoptotic process
M	0044297	cellular_component	cell body
M	0045202	cellular_component	synapse
M	0045471	biological_process	response to ethanol
M	0055003	biological_process	cardiac myofibril assembly
M	0055008	biological_process	cardiac muscle tissue morphogenesis
M	0060047	biological_process	heart contraction
M	0060048	biological_process	cardiac muscle contraction
M	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
M	0090131	biological_process	mesenchyme migration
M	0098978	cellular_component	glutamatergic synapse

Functional Information from PROSITE/UniProt

site_id	PS00326
Number of Residues	9
Details	TROPOMYOSIN Tropomyosins signature. LKEAEtRAE

Chain	Residue	Details
R	LEU232-GLU240

---

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
B	TYR55-GLY65

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
B	TRP358-GLU366

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
B	LEU106-ARG118

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"PubMed","id":"23911929","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"UniProtKB","id":"P62739","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68032","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	80
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P04692","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	216
Details	Region: {"description":"Actin-binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	42
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Modified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P02563","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P02563","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---