8ZB7

Human left ventricle ATM complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000146	molecular_function	microfilament motor activity
A	0000166	molecular_function	nucleotide binding
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005884	cellular_component	actin filament
A	0005925	cellular_component	focal adhesion
A	0007015	biological_process	actin filament organization
A	0009410	biological_process	response to xenobiotic stimulus
A	0010628	biological_process	positive regulation of gene expression
A	0015629	cellular_component	actin cytoskeleton
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0017022	molecular_function	myosin binding
A	0030017	cellular_component	sarcomere
A	0030027	cellular_component	lamellipodium
A	0030048	biological_process	actin filament-based movement
A	0030175	cellular_component	filopodium
A	0030240	biological_process	skeletal muscle thin filament assembly
A	0031032	biological_process	actomyosin structure organization
A	0031674	cellular_component	I band
A	0033275	biological_process	actin-myosin filament sliding
A	0044297	cellular_component	cell body
A	0045202	cellular_component	synapse
A	0045471	biological_process	response to ethanol
A	0055003	biological_process	cardiac myofibril assembly
A	0055008	biological_process	cardiac muscle tissue morphogenesis
A	0060047	biological_process	heart contraction
A	0060048	biological_process	cardiac muscle contraction
A	0070062	cellular_component	extracellular exosome
A	0072562	cellular_component	blood microparticle
A	0090131	biological_process	mesenchyme migration
A	0098978	cellular_component	glutamatergic synapse
B	0000146	molecular_function	microfilament motor activity
B	0000166	molecular_function	nucleotide binding
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005884	cellular_component	actin filament
B	0005925	cellular_component	focal adhesion
B	0007015	biological_process	actin filament organization
B	0009410	biological_process	response to xenobiotic stimulus
B	0010628	biological_process	positive regulation of gene expression
B	0015629	cellular_component	actin cytoskeleton
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0017022	molecular_function	myosin binding
B	0030017	cellular_component	sarcomere
B	0030027	cellular_component	lamellipodium
B	0030048	biological_process	actin filament-based movement
B	0030175	cellular_component	filopodium
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0031032	biological_process	actomyosin structure organization
B	0031674	cellular_component	I band
B	0033275	biological_process	actin-myosin filament sliding
B	0044297	cellular_component	cell body
B	0045202	cellular_component	synapse
B	0045471	biological_process	response to ethanol
B	0055003	biological_process	cardiac myofibril assembly
B	0055008	biological_process	cardiac muscle tissue morphogenesis
B	0060047	biological_process	heart contraction
B	0060048	biological_process	cardiac muscle contraction
B	0070062	cellular_component	extracellular exosome
B	0072562	cellular_component	blood microparticle
B	0090131	biological_process	mesenchyme migration
B	0098978	cellular_component	glutamatergic synapse
C	0000146	molecular_function	microfilament motor activity
C	0000166	molecular_function	nucleotide binding
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005884	cellular_component	actin filament
C	0005925	cellular_component	focal adhesion
C	0007015	biological_process	actin filament organization
C	0009410	biological_process	response to xenobiotic stimulus
C	0010628	biological_process	positive regulation of gene expression
C	0015629	cellular_component	actin cytoskeleton
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0017022	molecular_function	myosin binding
C	0030017	cellular_component	sarcomere
C	0030027	cellular_component	lamellipodium
C	0030048	biological_process	actin filament-based movement
C	0030175	cellular_component	filopodium
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0031032	biological_process	actomyosin structure organization
C	0031674	cellular_component	I band
C	0033275	biological_process	actin-myosin filament sliding
C	0044297	cellular_component	cell body
C	0045202	cellular_component	synapse
C	0045471	biological_process	response to ethanol
C	0055003	biological_process	cardiac myofibril assembly
C	0055008	biological_process	cardiac muscle tissue morphogenesis
C	0060047	biological_process	heart contraction
C	0060048	biological_process	cardiac muscle contraction
C	0070062	cellular_component	extracellular exosome
C	0072562	cellular_component	blood microparticle
C	0090131	biological_process	mesenchyme migration
C	0098978	cellular_component	glutamatergic synapse
D	0000146	molecular_function	microfilament motor activity
D	0000166	molecular_function	nucleotide binding
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005884	cellular_component	actin filament
D	0005925	cellular_component	focal adhesion
D	0007015	biological_process	actin filament organization
D	0009410	biological_process	response to xenobiotic stimulus
D	0010628	biological_process	positive regulation of gene expression
D	0015629	cellular_component	actin cytoskeleton
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0017022	molecular_function	myosin binding
D	0030017	cellular_component	sarcomere
D	0030027	cellular_component	lamellipodium
D	0030048	biological_process	actin filament-based movement
D	0030175	cellular_component	filopodium
D	0030240	biological_process	skeletal muscle thin filament assembly
D	0031032	biological_process	actomyosin structure organization
D	0031674	cellular_component	I band
D	0033275	biological_process	actin-myosin filament sliding
D	0044297	cellular_component	cell body
D	0045202	cellular_component	synapse
D	0045471	biological_process	response to ethanol
D	0055003	biological_process	cardiac myofibril assembly
D	0055008	biological_process	cardiac muscle tissue morphogenesis
D	0060047	biological_process	heart contraction
D	0060048	biological_process	cardiac muscle contraction
D	0070062	cellular_component	extracellular exosome
D	0072562	cellular_component	blood microparticle
D	0090131	biological_process	mesenchyme migration
D	0098978	cellular_component	glutamatergic synapse
E	0000146	molecular_function	microfilament motor activity
E	0000166	molecular_function	nucleotide binding
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005884	cellular_component	actin filament
E	0005925	cellular_component	focal adhesion
E	0007015	biological_process	actin filament organization
E	0009410	biological_process	response to xenobiotic stimulus
E	0010628	biological_process	positive regulation of gene expression
E	0015629	cellular_component	actin cytoskeleton
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0017022	molecular_function	myosin binding
E	0030017	cellular_component	sarcomere
E	0030027	cellular_component	lamellipodium
E	0030048	biological_process	actin filament-based movement
E	0030175	cellular_component	filopodium
E	0030240	biological_process	skeletal muscle thin filament assembly
E	0031032	biological_process	actomyosin structure organization
E	0031674	cellular_component	I band
E	0033275	biological_process	actin-myosin filament sliding
E	0044297	cellular_component	cell body
E	0045202	cellular_component	synapse
E	0045471	biological_process	response to ethanol
E	0055003	biological_process	cardiac myofibril assembly
E	0055008	biological_process	cardiac muscle tissue morphogenesis
E	0060047	biological_process	heart contraction
E	0060048	biological_process	cardiac muscle contraction
E	0070062	cellular_component	extracellular exosome
E	0072562	cellular_component	blood microparticle
E	0090131	biological_process	mesenchyme migration
E	0098978	cellular_component	glutamatergic synapse
F	0000146	molecular_function	microfilament motor activity
F	0000166	molecular_function	nucleotide binding
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005615	cellular_component	extracellular space
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005884	cellular_component	actin filament
F	0005925	cellular_component	focal adhesion
F	0007015	biological_process	actin filament organization
F	0009410	biological_process	response to xenobiotic stimulus
F	0010628	biological_process	positive regulation of gene expression
F	0015629	cellular_component	actin cytoskeleton
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0017022	molecular_function	myosin binding
F	0030017	cellular_component	sarcomere
F	0030027	cellular_component	lamellipodium
F	0030048	biological_process	actin filament-based movement
F	0030175	cellular_component	filopodium
F	0030240	biological_process	skeletal muscle thin filament assembly
F	0031032	biological_process	actomyosin structure organization
F	0031674	cellular_component	I band
F	0033275	biological_process	actin-myosin filament sliding
F	0044297	cellular_component	cell body
F	0045202	cellular_component	synapse
F	0045471	biological_process	response to ethanol
F	0055003	biological_process	cardiac myofibril assembly
F	0055008	biological_process	cardiac muscle tissue morphogenesis
F	0060047	biological_process	heart contraction
F	0060048	biological_process	cardiac muscle contraction
F	0070062	cellular_component	extracellular exosome
F	0072562	cellular_component	blood microparticle
F	0090131	biological_process	mesenchyme migration
F	0098978	cellular_component	glutamatergic synapse
G	0003774	molecular_function	cytoskeletal motor activity
G	0005524	molecular_function	ATP binding
G	0016459	cellular_component	myosin complex
G	0051015	molecular_function	actin filament binding
H	0003774	molecular_function	cytoskeletal motor activity
H	0005524	molecular_function	ATP binding
H	0016459	cellular_component	myosin complex
H	0051015	molecular_function	actin filament binding
I	0003774	molecular_function	cytoskeletal motor activity
I	0005524	molecular_function	ATP binding
I	0016459	cellular_component	myosin complex
I	0051015	molecular_function	actin filament binding
J	0003774	molecular_function	cytoskeletal motor activity
J	0005524	molecular_function	ATP binding
J	0016459	cellular_component	myosin complex
J	0051015	molecular_function	actin filament binding
K	0003774	molecular_function	cytoskeletal motor activity
K	0005524	molecular_function	ATP binding
K	0016459	cellular_component	myosin complex
K	0051015	molecular_function	actin filament binding
M	0003774	molecular_function	cytoskeletal motor activity
M	0005524	molecular_function	ATP binding
M	0016459	cellular_component	myosin complex
M	0051015	molecular_function	actin filament binding

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
B	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
B	TRP356-GLU364

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
B	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	294
Details	Domain: {"description":"Myosin N-terminal SH3-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	216
Details	Region: {"description":"Actin-binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	42
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P02563","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P68033","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"23673617","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Cross-link: {"description":"Isoglutamyl lysine isopeptide (Lys-Glu) (interchain with E-272); by Vibrio toxins RtxA and VgrG1","evidences":[{"source":"UniProtKB","id":"P60709","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	12
Details	Cross-link: {"description":"Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-52); by Vibrio toxins RtxA and VgrG1","evidences":[{"source":"UniProtKB","id":"P60709","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	80
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P04692","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P58771","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---