8Z7Z

SLC19A2-Thiamine inward structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0007283	biological_process	spermatogenesis
A	0008517	molecular_function	folic acid transmembrane transporter activity
A	0009229	biological_process	thiamine diphosphate biosynthetic process
A	0015234	molecular_function	thiamine transmembrane transporter activity
A	0015884	biological_process	folic acid transport
A	0015888	biological_process	thiamine transport
A	0016020	cellular_component	membrane
A	0031923	biological_process	pyridoxine transport
A	0042723	biological_process	thiamine-containing compound metabolic process
A	0051180	biological_process	vitamin transport
A	0071934	biological_process	thiamine transmembrane transport
A	0090482	molecular_function	vitamin transmembrane transporter activity

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ATFqIAANLSMERYAlV

Chain	Residue	Details
A	ALA407-VAL423

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	81
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	215
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	39
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	7
Details	Site: {"description":"Essential for pyridoxine transport","evidences":[{"source":"PubMed","id":"35724964","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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