8Z7U
SLC19A3-Fedratinib outward structure
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| A | 0015234 | molecular_function | thiamine transmembrane transporter activity |
| A | 0015888 | biological_process | thiamine transport |
| A | 0016020 | cellular_component | membrane |
| A | 0031923 | biological_process | pyridoxine transport |
| A | 0042723 | biological_process | thiamine-containing compound metabolic process |
| A | 0051180 | biological_process | vitamin transport |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071934 | biological_process | thiamine transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 167 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-SER7 | |
| A | ASP75-PRO81 | |
| A | SER132-ARG144 | |
| A | PRO191-SER282 | |
| A | LYS338-ASP342 | |
| A | ASN397-LEU405 | |
| A | ARG456-LEU496 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 240 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU8-MET28 | |
| A | TYR376-VAL396 | |
| A | VAL406-VAL426 | |
| A | VAL435-MET455 | |
| A | GLU54-THR74 | |
| A | VAL82-GLY102 | |
| A | PHE111-VAL131 | |
| A | SER145-ALA165 | |
| A | PHE170-LEU190 | |
| A | LEU283-TRP303 | |
| A | GLY317-VAL337 | |
| A | LEU343-MET363 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 64 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG29-ASN53 | |
| A | VAL103-GLU110 | |
| A | ASN166-TYR169 | |
| A | ASP304-ASN316 | |
| A | HIS364-GLY375 | |
| A | ASP427-PRO434 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | SITE: Essential for pyridoxine transport => ECO:0000269|PubMed:35724964 |
| Chain | Residue | Details |
| A | GLN86 | |
| A | GLY87 | |
| A | ILE91 | |
| A | THR93 | |
| A | TRP94 | |
| A | SER168 | |
| A | ASN173 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN45 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN166 |
