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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8Z5P

human phosphorylase kinase - inactive state

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0004689molecular_functionphosphorylase kinase activity
A0005516molecular_functioncalmodulin binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005964cellular_componentphosphorylase kinase complex
A0005975biological_processcarbohydrate metabolic process
A0005977biological_processglycogen metabolic process
A0005980biological_processglycogen catabolic process
A0006091biological_processgeneration of precursor metabolites and energy
A0045819biological_processpositive regulation of glycogen catabolic process
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005964cellular_componentphosphorylase kinase complex
B0005975biological_processcarbohydrate metabolic process
B0005977biological_processglycogen metabolic process
B0005980biological_processglycogen catabolic process
B0006091biological_processgeneration of precursor metabolites and energy
C0000166molecular_functionnucleotide binding
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004689molecular_functionphosphorylase kinase activity
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005964cellular_componentphosphorylase kinase complex
C0005975biological_processcarbohydrate metabolic process
C0005977biological_processglycogen metabolic process
C0005980biological_processglycogen catabolic process
C0006468biological_processprotein phosphorylation
C0007165biological_processsignal transduction
C0016301molecular_functionkinase activity
C0016740molecular_functiontransferase activity
C0019899molecular_functionenzyme binding
C0050321molecular_functiontau-protein kinase activity
C0106310molecular_functionprotein serine kinase activity
D0000785cellular_componentchromatin
D0000922cellular_componentspindle pole
D0001975biological_processresponse to amphetamine
D0002027biological_processregulation of heart rate
D0005246molecular_functioncalcium channel regulator activity
D0005509molecular_functioncalcium ion binding
D0005513biological_processdetection of calcium ion
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005876cellular_componentspindle microtubule
D0005886cellular_componentplasma membrane
D0007186biological_processG protein-coupled receptor signaling pathway
D0008076cellular_componentvoltage-gated potassium channel complex
D0008179molecular_functionadenylate cyclase binding
D0010856molecular_functionadenylate cyclase activator activity
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0016020cellular_componentmembrane
D0019901molecular_functionprotein kinase binding
D0019904molecular_functionprotein domain specific binding
D0021762biological_processsubstantia nigra development
D0030017cellular_componentsarcomere
D0030235molecular_functionnitric-oxide synthase regulator activity
D0030426cellular_componentgrowth cone
D0030672cellular_componentsynaptic vesicle membrane
D0031432molecular_functiontitin binding
D0031800molecular_functiontype 3 metabotropic glutamate receptor binding
D0031966cellular_componentmitochondrial membrane
D0031982cellular_componentvesicle
D0032465biological_processregulation of cytokinesis
D0032991cellular_componentprotein-containing complex
D0034704cellular_componentcalcium channel complex
D0043209cellular_componentmyelin sheath
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0043548molecular_functionphosphatidylinositol 3-kinase binding
D0044305cellular_componentcalyx of Held
D0044325molecular_functiontransmembrane transporter binding
D0046872molecular_functionmetal ion binding
D0048306molecular_functioncalcium-dependent protein binding
D0050998molecular_functionnitric-oxide synthase binding
D0051412biological_processresponse to corticosterone
D0051592biological_processresponse to calcium ion
D0055117biological_processregulation of cardiac muscle contraction
D0060291biological_processlong-term synaptic potentiation
D0072542molecular_functionprotein phosphatase activator activity
D0090150biological_processestablishment of protein localization to membrane
D0090151biological_processestablishment of protein localization to mitochondrial membrane
D0097225cellular_componentsperm midpiece
D0097720biological_processcalcineurin-mediated signaling
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098901biological_processregulation of cardiac muscle cell action potential
D0099523cellular_componentpresynaptic cytosol
D0099524cellular_componentpostsynaptic cytosol
D0140238biological_processpresynaptic endocytosis
D0141110molecular_functiontransporter inhibitor activity
D1900242biological_processregulation of synaptic vesicle endocytosis
D1901842biological_processnegative regulation of high voltage-gated calcium channel activity
D1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
D1902494cellular_componentcatalytic complex
D1905913biological_processnegative regulation of calcium ion export across plasma membrane
D2000300biological_processregulation of synaptic vesicle exocytosis
E0004689molecular_functionphosphorylase kinase activity
E0005516molecular_functioncalmodulin binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0005964cellular_componentphosphorylase kinase complex
E0005975biological_processcarbohydrate metabolic process
E0005977biological_processglycogen metabolic process
E0005980biological_processglycogen catabolic process
E0006091biological_processgeneration of precursor metabolites and energy
E0045819biological_processpositive regulation of glycogen catabolic process
F0005515molecular_functionprotein binding
F0005516molecular_functioncalmodulin binding
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005964cellular_componentphosphorylase kinase complex
F0005975biological_processcarbohydrate metabolic process
F0005977biological_processglycogen metabolic process
F0005980biological_processglycogen catabolic process
F0006091biological_processgeneration of precursor metabolites and energy
G0000166molecular_functionnucleotide binding
G0004672molecular_functionprotein kinase activity
G0004674molecular_functionprotein serine/threonine kinase activity
G0004689molecular_functionphosphorylase kinase activity
G0005516molecular_functioncalmodulin binding
G0005524molecular_functionATP binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005964cellular_componentphosphorylase kinase complex
G0005975biological_processcarbohydrate metabolic process
G0005977biological_processglycogen metabolic process
G0005980biological_processglycogen catabolic process
G0006468biological_processprotein phosphorylation
G0007165biological_processsignal transduction
G0016301molecular_functionkinase activity
G0016740molecular_functiontransferase activity
G0019899molecular_functionenzyme binding
G0050321molecular_functiontau-protein kinase activity
G0106310molecular_functionprotein serine kinase activity
H0000785cellular_componentchromatin
H0000922cellular_componentspindle pole
H0001975biological_processresponse to amphetamine
H0002027biological_processregulation of heart rate
H0005246molecular_functioncalcium channel regulator activity
H0005509molecular_functioncalcium ion binding
H0005513biological_processdetection of calcium ion
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005813cellular_componentcentrosome
H0005819cellular_componentspindle
H0005829cellular_componentcytosol
H0005876cellular_componentspindle microtubule
H0005886cellular_componentplasma membrane
H0007186biological_processG protein-coupled receptor signaling pathway
H0008076cellular_componentvoltage-gated potassium channel complex
H0008179molecular_functionadenylate cyclase binding
H0010856molecular_functionadenylate cyclase activator activity
H0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H0016020cellular_componentmembrane
H0019901molecular_functionprotein kinase binding
H0019904molecular_functionprotein domain specific binding
H0021762biological_processsubstantia nigra development
H0030017cellular_componentsarcomere
H0030235molecular_functionnitric-oxide synthase regulator activity
H0030426cellular_componentgrowth cone
H0030672cellular_componentsynaptic vesicle membrane
H0031432molecular_functiontitin binding
H0031800molecular_functiontype 3 metabotropic glutamate receptor binding
H0031966cellular_componentmitochondrial membrane
H0031982cellular_componentvesicle
H0032465biological_processregulation of cytokinesis
H0032991cellular_componentprotein-containing complex
H0034704cellular_componentcalcium channel complex
H0043209cellular_componentmyelin sheath
H0043539molecular_functionprotein serine/threonine kinase activator activity
H0043548molecular_functionphosphatidylinositol 3-kinase binding
H0044305cellular_componentcalyx of Held
H0044325molecular_functiontransmembrane transporter binding
H0046872molecular_functionmetal ion binding
H0048306molecular_functioncalcium-dependent protein binding
H0050998molecular_functionnitric-oxide synthase binding
H0051412biological_processresponse to corticosterone
H0051592biological_processresponse to calcium ion
H0055117biological_processregulation of cardiac muscle contraction
H0060291biological_processlong-term synaptic potentiation
H0072542molecular_functionprotein phosphatase activator activity
H0090150biological_processestablishment of protein localization to membrane
H0090151biological_processestablishment of protein localization to mitochondrial membrane
H0097225cellular_componentsperm midpiece
H0097720biological_processcalcineurin-mediated signaling
H0098685cellular_componentSchaffer collateral - CA1 synapse
H0098901biological_processregulation of cardiac muscle cell action potential
H0099523cellular_componentpresynaptic cytosol
H0099524cellular_componentpostsynaptic cytosol
H0140238biological_processpresynaptic endocytosis
H0141110molecular_functiontransporter inhibitor activity
H1900242biological_processregulation of synaptic vesicle endocytosis
H1901842biological_processnegative regulation of high voltage-gated calcium channel activity
H1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
H1902494cellular_componentcatalytic complex
H1905913biological_processnegative regulation of calcium ion export across plasma membrane
H2000300biological_processregulation of synaptic vesicle exocytosis
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
DASP21-LEU33
DASP57-PHE69
DASP94-LEU106
DASP130-PHE142
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGVSSVVRrCihkptsqe..........YAVK
ChainResidueDetails
CLEU26-LYS49
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNILL
ChainResidueDetails
CILE146-LEU158
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues176
DetailsRegion: {"description":"Calmodulin-binding","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q64649","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsLipidation: {"description":"S-farnesyl cysteine","evidences":[{"source":"UniProtKB","id":"P18688","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues536
DetailsDomain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues48
DetailsRegion: {"description":"Calmodulin-binding (domain-N)"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues48
DetailsRegion: {"description":"Calmodulin-binding (domain-C)"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues70
DetailsDomain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues70
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues70
DetailsDomain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues40
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by CaMK4","evidences":[{"source":"UniProtKB","id":"P0DP31","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62157","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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