8Z0A
Human GYS1-GYG2 complex (apo)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004373 | molecular_function | alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005536 | molecular_function | D-glucose binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005977 | biological_process | glycogen metabolic process |
| A | 0005978 | biological_process | glycogen biosynthetic process |
| A | 0007507 | biological_process | heart development |
| A | 0016020 | cellular_component | membrane |
| A | 0016234 | cellular_component | inclusion body |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0061547 | molecular_function | glycogen synthase activity, transferring glucose-1-phosphate |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004373 | molecular_function | alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005536 | molecular_function | D-glucose binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005977 | biological_process | glycogen metabolic process |
| B | 0005978 | biological_process | glycogen biosynthetic process |
| B | 0007507 | biological_process | heart development |
| B | 0016020 | cellular_component | membrane |
| B | 0016234 | cellular_component | inclusion body |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0061547 | molecular_function | glycogen synthase activity, transferring glucose-1-phosphate |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004373 | molecular_function | alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005536 | molecular_function | D-glucose binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005977 | biological_process | glycogen metabolic process |
| C | 0005978 | biological_process | glycogen biosynthetic process |
| C | 0007507 | biological_process | heart development |
| C | 0016020 | cellular_component | membrane |
| C | 0016234 | cellular_component | inclusion body |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0061547 | molecular_function | glycogen synthase activity, transferring glucose-1-phosphate |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004373 | molecular_function | alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005536 | molecular_function | D-glucose binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005977 | biological_process | glycogen metabolic process |
| D | 0005978 | biological_process | glycogen biosynthetic process |
| D | 0007507 | biological_process | heart development |
| D | 0016020 | cellular_component | membrane |
| D | 0016234 | cellular_component | inclusion body |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0061547 | molecular_function | glycogen synthase activity, transferring glucose-1-phosphate |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 60 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P46976 |
| Chain | Residue | Details |
| E | LEU42 | |
| E | SER167 | |
| E | ASP193 | |
| E | ASP196 | |
| E | GLN197 | |
| E | GLY248 | |
| E | LYS251 | |
| F | LEU42 | |
| F | THR44 | |
| F | TYR48 | |
| F | ARG110 | |
| E | THR44 | |
| F | LYS119 | |
| F | ASP135 | |
| F | ALA136 | |
| F | ASP137 | |
| F | ASN166 | |
| F | SER167 | |
| F | ASP193 | |
| F | ASP196 | |
| F | GLN197 | |
| F | GLY248 | |
| E | TYR48 | |
| F | LYS251 | |
| G | LEU42 | |
| G | THR44 | |
| G | TYR48 | |
| G | ARG110 | |
| G | LYS119 | |
| G | ASP135 | |
| G | ALA136 | |
| G | ASP137 | |
| G | ASN166 | |
| E | ARG110 | |
| G | SER167 | |
| G | ASP193 | |
| G | ASP196 | |
| G | GLN197 | |
| G | GLY248 | |
| G | LYS251 | |
| H | LEU42 | |
| H | THR44 | |
| H | TYR48 | |
| H | ARG110 | |
| E | LYS119 | |
| H | LYS119 | |
| H | ASP135 | |
| H | ALA136 | |
| H | ASP137 | |
| H | ASN166 | |
| H | SER167 | |
| H | ASP193 | |
| H | ASP196 | |
| H | GLN197 | |
| H | GLY248 | |
| E | ASP135 | |
| H | LYS251 | |
| E | ALA136 | |
| E | ASP137 | |
| E | ASN166 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P13280 |
| Chain | Residue | Details |
| E | ASN45 | |
| B | GLU510 | |
| B | TRP512 | |
| B | GLY513 | |
| C | HIS205 | |
| C | ARG211 | |
| C | ARG331 | |
| C | GLU510 | |
| C | TRP512 | |
| C | GLY513 | |
| D | HIS205 | |
| E | HIS245 | |
| D | ARG211 | |
| D | ARG331 | |
| D | GLU510 | |
| D | TRP512 | |
| D | GLY513 | |
| F | ASN45 | |
| F | HIS245 | |
| G | ASN45 | |
| G | HIS245 | |
| H | ASN45 | |
| H | HIS245 | |
| B | ARG331 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Important for catalytic activity => ECO:0000250|UniProtKB:P13280 |
| Chain | Residue | Details |
| E | LYS119 | |
| F | LYS119 | |
| G | LYS119 | |
| H | LYS119 | |
| C | HIS291 | |
| C | GLU292 | |
| D | HIS291 | |
| D | GLU292 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| E | SER368 | |
| H | SER368 | |
| H | SER399 | |
| H | SER459 | |
| D | GLN294 | |
| D | HIS501 | |
| D | ARG582 | |
| D | ARG586 | |
| E | SER399 | |
| E | SER459 | |
| F | SER368 | |
| F | SER399 | |
| F | SER459 | |
| G | SER368 | |
| G | SER399 | |
| G | SER459 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CARBOHYD: O-linked (Glc...) tyrosine => ECO:0000269|PubMed:9857012 |
| Chain | Residue | Details |
| E | TYR228 | |
| F | TYR228 | |
| G | TYR228 | |
| H | TYR228 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P13834 |
| Chain | Residue | Details |
| A | SER11 | |
| A | SER698 | |
| B | SER11 | |
| B | SER698 | |
| C | SER11 | |
| C | SER698 | |
| D | SER11 | |
| D | SER698 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:35690592, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER412 | |
| B | SER412 | |
| C | SER412 | |
| D | SER412 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:35690592, ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER641 | |
| A | SER645 | |
| B | SER641 | |
| B | SER645 | |
| C | SER641 | |
| C | SER645 | |
| D | SER641 | |
| D | SER645 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER649 | |
| B | SER649 | |
| C | SER649 | |
| D | SER649 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:35690592 |
| Chain | Residue | Details |
| A | SER652 | |
| A | SER731 | |
| B | SER652 | |
| B | SER731 | |
| C | SER652 | |
| C | SER731 | |
| D | SER652 | |
| D | SER731 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by GSK3-alpha and GSK3-beta => ECO:0000269|PubMed:35690592 |
| Chain | Residue | Details |
| A | SER653 | |
| B | SER653 | |
| C | SER653 | |
| D | SER653 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:35690592 |
| Chain | Residue | Details |
| A | SER657 | |
| B | SER657 | |
| C | SER657 | |
| D | SER657 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR700 | |
| B | THR700 | |
| C | THR700 | |
| D | THR700 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER710 | |
| B | SER710 | |
| C | SER710 | |
| D | SER710 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9Z1E4 |
| Chain | Residue | Details |
| A | THR721 | |
| B | THR721 | |
| C | THR721 | |
| D | THR721 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:35690592, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER727 | |
| B | SER727 | |
| C | SER727 | |
| D | SER727 |
