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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8YYU

A tetrameric STAT1-DNA complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000785cellular_componentchromatin
A0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
A0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
A0001222molecular_functiontranscription corepressor binding
A0001223molecular_functiontranscription coactivator binding
A0001937biological_processnegative regulation of endothelial cell proliferation
A0002053biological_processpositive regulation of mesenchymal cell proliferation
A0002230biological_processpositive regulation of defense response to virus by host
A0003340biological_processnegative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
A0003677molecular_functionDNA binding
A0003690molecular_functiondouble-stranded DNA binding
A0003700molecular_functionDNA-binding transcription factor activity
A0005164molecular_functiontumor necrosis factor receptor binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006351biological_processDNA-templated transcription
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0006952biological_processdefense response
A0007165biological_processsignal transduction
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0016525biological_processnegative regulation of angiogenesis
A0019899molecular_functionenzyme binding
A0032727biological_processpositive regulation of interferon-alpha production
A0032991cellular_componentprotein-containing complex
A0033209biological_processtumor necrosis factor-mediated signaling pathway
A0034341biological_processresponse to type II interferon
A0035035molecular_functionhistone acetyltransferase binding
A0035456biological_processresponse to interferon-beta
A0035458biological_processcellular response to interferon-beta
A0038111biological_processinterleukin-7-mediated signaling pathway
A0038113biological_processinterleukin-9-mediated signaling pathway
A0042127biological_processregulation of cell population proliferation
A0042393molecular_functionhistone binding
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042981biological_processregulation of apoptotic process
A0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
A0043434biological_processresponse to peptide hormone
A0043542biological_processendothelial cell migration
A0044389molecular_functionubiquitin-like protein ligase binding
A0045296molecular_functioncadherin binding
A0045648biological_processpositive regulation of erythrocyte differentiation
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046725biological_processnegative regulation by virus of viral protein levels in host cell
A0048471cellular_componentperinuclear region of cytoplasm
A0051093biological_processnegative regulation of developmental process
A0051607biological_processdefense response to virus
A0060333biological_processtype II interferon-mediated signaling pathway
A0060337biological_processtype I interferon-mediated signaling pathway
A0061326biological_processrenal tubule development
A0070106biological_processinterleukin-27-mediated signaling pathway
A0070721cellular_componentISGF3 complex
A0071346biological_processcellular response to type II interferon
A0072136biological_processmetanephric mesenchymal cell proliferation involved in metanephros development
A0072162biological_processmetanephric mesenchymal cell differentiation
A0072308biological_processnegative regulation of metanephric nephron tubule epithelial cell differentiation
A0090575cellular_componentRNA polymerase II transcription regulator complex
A0097696biological_processcell surface receptor signaling pathway via STAT
A1990841molecular_functionpromoter-specific chromatin binding
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000785cellular_componentchromatin
D0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
D0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
D0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
D0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
D0001222molecular_functiontranscription corepressor binding
D0001223molecular_functiontranscription coactivator binding
D0001937biological_processnegative regulation of endothelial cell proliferation
D0002053biological_processpositive regulation of mesenchymal cell proliferation
D0002230biological_processpositive regulation of defense response to virus by host
D0003340biological_processnegative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
D0003677molecular_functionDNA binding
D0003690molecular_functiondouble-stranded DNA binding
D0003700molecular_functionDNA-binding transcription factor activity
D0005164molecular_functiontumor necrosis factor receptor binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006351biological_processDNA-templated transcription
D0006355biological_processregulation of DNA-templated transcription
D0006357biological_processregulation of transcription by RNA polymerase II
D0006952biological_processdefense response
D0007165biological_processsignal transduction
D0007259biological_processcell surface receptor signaling pathway via JAK-STAT
D0016525biological_processnegative regulation of angiogenesis
D0019899molecular_functionenzyme binding
D0032727biological_processpositive regulation of interferon-alpha production
D0032991cellular_componentprotein-containing complex
D0033209biological_processtumor necrosis factor-mediated signaling pathway
D0034341biological_processresponse to type II interferon
D0035035molecular_functionhistone acetyltransferase binding
D0035456biological_processresponse to interferon-beta
D0035458biological_processcellular response to interferon-beta
D0038111biological_processinterleukin-7-mediated signaling pathway
D0038113biological_processinterleukin-9-mediated signaling pathway
D0042127biological_processregulation of cell population proliferation
D0042393molecular_functionhistone binding
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0042981biological_processregulation of apoptotic process
D0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
D0043434biological_processresponse to peptide hormone
D0043542biological_processendothelial cell migration
D0044389molecular_functionubiquitin-like protein ligase binding
D0045296molecular_functioncadherin binding
D0045648biological_processpositive regulation of erythrocyte differentiation
D0045893biological_processpositive regulation of DNA-templated transcription
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046725biological_processnegative regulation by virus of viral protein levels in host cell
D0048471cellular_componentperinuclear region of cytoplasm
D0051093biological_processnegative regulation of developmental process
D0051607biological_processdefense response to virus
D0060333biological_processtype II interferon-mediated signaling pathway
D0060337biological_processtype I interferon-mediated signaling pathway
D0061326biological_processrenal tubule development
D0070106biological_processinterleukin-27-mediated signaling pathway
D0070721cellular_componentISGF3 complex
D0071346biological_processcellular response to type II interferon
D0072136biological_processmetanephric mesenchymal cell proliferation involved in metanephros development
D0072162biological_processmetanephric mesenchymal cell differentiation
D0072308biological_processnegative regulation of metanephric nephron tubule epithelial cell differentiation
D0090575cellular_componentRNA polymerase II transcription regulator complex
D0097696biological_processcell surface receptor signaling pathway via STAT
D1990841molecular_functionpromoter-specific chromatin binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues194
DetailsDomain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues12
DetailsModified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"28753426","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"ADP-ribosyl glutamic acid; by PARP14","evidences":[{"source":"PubMed","id":"27796300","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine; by JAK1, JAK2 or TYK2","evidences":[{"source":"PubMed","id":"17561467","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19088846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21135090","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22065572","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26479788","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27796300","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28753426","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38621137","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7657660","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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