8YX7

Structure of a Cys-loop Receptor under Acidic Condition

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0008270	molecular_function	zinc ion binding
A	0010043	biological_process	response to zinc ion
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0098655	biological_process	monoatomic cation transmembrane transport
A	0099094	molecular_function	ligand-gated monoatomic cation channel activity
A	0160128	molecular_function	pH-gated monoatomic ion channel activity
A	1902495	cellular_component	transmembrane transporter complex
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0008270	molecular_function	zinc ion binding
B	0010043	biological_process	response to zinc ion
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0098655	biological_process	monoatomic cation transmembrane transport
B	0099094	molecular_function	ligand-gated monoatomic cation channel activity
B	0160128	molecular_function	pH-gated monoatomic ion channel activity
B	1902495	cellular_component	transmembrane transporter complex
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0008270	molecular_function	zinc ion binding
C	0010043	biological_process	response to zinc ion
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0098655	biological_process	monoatomic cation transmembrane transport
C	0099094	molecular_function	ligand-gated monoatomic cation channel activity
C	0160128	molecular_function	pH-gated monoatomic ion channel activity
C	1902495	cellular_component	transmembrane transporter complex
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0008270	molecular_function	zinc ion binding
D	0010043	biological_process	response to zinc ion
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0098655	biological_process	monoatomic cation transmembrane transport
D	0099094	molecular_function	ligand-gated monoatomic cation channel activity
D	0160128	molecular_function	pH-gated monoatomic ion channel activity
D	1902495	cellular_component	transmembrane transporter complex
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0008270	molecular_function	zinc ion binding
E	0010043	biological_process	response to zinc ion
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0098655	biological_process	monoatomic cation transmembrane transport
E	0099094	molecular_function	ligand-gated monoatomic cation channel activity
E	0160128	molecular_function	pH-gated monoatomic ion channel activity
E	1902495	cellular_component	transmembrane transporter complex

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CnFeLlhFPrDhsnC

Chain	Residue	Details
A	CYS157-CYS171

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	100
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	50
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	100
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	55
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	100
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	100
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	15
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---