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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8YWB

a protein with a ligand

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000139cellular_componentGolgi membrane
A0000421cellular_componentautophagosome membrane
A0001819biological_processpositive regulation of cytokine production
A0002218biological_processactivation of innate immune response
A0002221biological_processpattern recognition receptor signaling pathway
A0002230biological_processpositive regulation of defense response to virus by host
A0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
A0003713molecular_functiontranscription coactivator activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005741cellular_componentmitochondrial outer membrane
A0005768cellular_componentendosome
A0005776cellular_componentautophagosome
A0005777cellular_componentperoxisome
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006914biological_processautophagy
A0015252molecular_functionproton channel activity
A0015485molecular_functioncholesterol binding
A0016239biological_processpositive regulation of macroautophagy
A0019901molecular_functionprotein kinase binding
A0030659cellular_componentcytoplasmic vesicle membrane
A0030667cellular_componentsecretory granule membrane
A0031625molecular_functionubiquitin protein ligase binding
A0032481biological_processpositive regulation of type I interferon production
A0032588cellular_componenttrans-Golgi network membrane
A0032728biological_processpositive regulation of interferon-beta production
A0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
A0035438molecular_functioncyclic-di-GMP binding
A0035591molecular_functionsignaling adaptor activity
A0036020cellular_componentendolysosome membrane
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0045087biological_processinnate immune response
A0045820biological_processnegative regulation of glycolytic process
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048471cellular_componentperinuclear region of cytoplasm
A0051259biological_processprotein complex oligomerization
A0051607biological_processdefense response to virus
A0055088biological_processlipid homeostasis
A0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
A0061507molecular_function2',3'-cyclic GMP-AMP binding
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0061709biological_processreticulophagy
A0070972biological_processprotein localization to endoplasmic reticulum
A0071360biological_processcellular response to exogenous dsRNA
A0080025molecular_functionphosphatidylinositol-3,5-bisphosphate binding
A0090398biological_processcellular senescence
A0120283molecular_functionprotein serine/threonine kinase binding
A0140367biological_processantibacterial innate immune response
A0140374biological_processantiviral innate immune response
A0140896biological_processcGAS/STING signaling pathway
A1902554cellular_componentserine/threonine protein kinase complex
A1902600biological_processproton transmembrane transport
A1904262biological_processnegative regulation of TORC1 signaling
A1905673biological_processpositive regulation of lysosome organization
A1990231cellular_componentSTING complex
D0000045biological_processautophagosome assembly
D0000139cellular_componentGolgi membrane
D0000421cellular_componentautophagosome membrane
D0001819biological_processpositive regulation of cytokine production
D0002218biological_processactivation of innate immune response
D0002221biological_processpattern recognition receptor signaling pathway
D0002230biological_processpositive regulation of defense response to virus by host
D0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
D0003713molecular_functiontranscription coactivator activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005741cellular_componentmitochondrial outer membrane
D0005768cellular_componentendosome
D0005776cellular_componentautophagosome
D0005777cellular_componentperoxisome
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006914biological_processautophagy
D0015252molecular_functionproton channel activity
D0015485molecular_functioncholesterol binding
D0016239biological_processpositive regulation of macroautophagy
D0019901molecular_functionprotein kinase binding
D0030659cellular_componentcytoplasmic vesicle membrane
D0030667cellular_componentsecretory granule membrane
D0031625molecular_functionubiquitin protein ligase binding
D0032481biological_processpositive regulation of type I interferon production
D0032588cellular_componenttrans-Golgi network membrane
D0032728biological_processpositive regulation of interferon-beta production
D0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
D0035438molecular_functioncyclic-di-GMP binding
D0035591molecular_functionsignaling adaptor activity
D0036020cellular_componentendolysosome membrane
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0045087biological_processinnate immune response
D0045820biological_processnegative regulation of glycolytic process
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0048471cellular_componentperinuclear region of cytoplasm
D0051259biological_processprotein complex oligomerization
D0051607biological_processdefense response to virus
D0055088biological_processlipid homeostasis
D0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
D0061507molecular_function2',3'-cyclic GMP-AMP binding
D0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
D0061709biological_processreticulophagy
D0070972biological_processprotein localization to endoplasmic reticulum
D0071360biological_processcellular response to exogenous dsRNA
D0080025molecular_functionphosphatidylinositol-3,5-bisphosphate binding
D0090398biological_processcellular senescence
D0120283molecular_functionprotein serine/threonine kinase binding
D0140367biological_processantibacterial innate immune response
D0140374biological_processantiviral innate immune response
D0140896biological_processcGAS/STING signaling pathway
D1902554cellular_componentserine/threonine protein kinase complex
D1902600biological_processproton transmembrane transport
D1904262biological_processnegative regulation of TORC1 signaling
D1905673biological_processpositive regulation of lysosome organization
D1990231cellular_componentSTING complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22579474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22705373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728659","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F9G","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728659","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"37379839","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GJX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22579474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22705373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F9G","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"37832545","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"UniProtKB","id":"Q3TBT3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

254917

PDB entries from 2026-06-10

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