8YW6
Cryo-EM structure of apo human mitochondrial pyruvate carrier in the IMS-open conformation at pH 8.0
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0006850 | biological_process | pyruvate import into mitochondria |
| A | 0016020 | cellular_component | membrane |
| A | 0050833 | molecular_function | pyruvate transmembrane transporter activity |
| A | 0098800 | cellular_component | inner mitochondrial membrane protein complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0006086 | biological_process | pyruvate decarboxylation to acetyl-CoA |
| B | 0006850 | biological_process | pyruvate import into mitochondria |
| B | 0016020 | cellular_component | membrane |
| B | 0035774 | biological_process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0050833 | molecular_function | pyruvate transmembrane transporter activity |
| B | 0098800 | cellular_component | inner mitochondrial membrane protein complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 79 |
| Details | Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"27317664","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 94 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 31 |
| Details | Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"27317664","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P63030","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
