Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8YVP

canine immunoproteasome 20S subunit in complex with compound 1

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000502	cellular_component	proteasome complex
a	0001530	molecular_function	lipopolysaccharide binding
a	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005737	cellular_component	cytoplasm
a	0005739	cellular_component	mitochondrion
a	0005829	cellular_component	cytosol
a	0005839	cellular_component	proteasome core complex
a	0019774	cellular_component	proteasome core complex, beta-subunit complex
a	0036064	cellular_component	ciliary basal body
b	0000502	cellular_component	proteasome complex
b	0000932	cellular_component	P-body
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005839	cellular_component	proteasome core complex
b	0009615	biological_process	response to virus
b	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0000502	cellular_component	proteasome complex
G	0001530	molecular_function	lipopolysaccharide binding
G	0002376	biological_process	immune system process
G	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
H	0000502	cellular_component	proteasome complex
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005839	cellular_component	proteasome core complex
H	0019773	cellular_component	proteasome core complex, alpha-subunit complex
I	0000502	cellular_component	proteasome complex
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005839	cellular_component	proteasome core complex
I	0019773	cellular_component	proteasome core complex, alpha-subunit complex
I	0042802	molecular_function	identical protein binding
J	0000502	cellular_component	proteasome complex
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0019773	cellular_component	proteasome core complex, alpha-subunit complex
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0052548	biological_process	regulation of endopeptidase activity
K	0000502	cellular_component	proteasome complex
K	0000932	cellular_component	P-body
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005839	cellular_component	proteasome core complex
K	0005840	cellular_component	ribosome
K	0007519	biological_process	skeletal muscle tissue development
K	0016363	cellular_component	nuclear matrix
K	0019773	cellular_component	proteasome core complex, alpha-subunit complex
K	0030016	cellular_component	myofibril
K	0030017	cellular_component	sarcomere
K	0051059	molecular_function	NF-kappaB binding
K	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0000502	cellular_component	proteasome complex
L	0001530	molecular_function	lipopolysaccharide binding
L	0002376	biological_process	immune system process
L	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005813	cellular_component	centrosome
L	0005829	cellular_component	cytosol
L	0005839	cellular_component	proteasome core complex
L	0019773	cellular_component	proteasome core complex, alpha-subunit complex
M	0000502	cellular_component	proteasome complex
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005839	cellular_component	proteasome core complex
M	0019773	cellular_component	proteasome core complex, alpha-subunit complex
N	0000502	cellular_component	proteasome complex
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005839	cellular_component	proteasome core complex
N	0019773	cellular_component	proteasome core complex, alpha-subunit complex
N	0042802	molecular_function	identical protein binding
O	0000502	cellular_component	proteasome complex
O	0000932	cellular_component	P-body
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005839	cellular_component	proteasome core complex
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0043231	cellular_component	intracellular membrane-bounded organelle
P	0000502	cellular_component	proteasome complex
P	0000932	cellular_component	P-body
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005839	cellular_component	proteasome core complex
P	0009615	biological_process	response to virus
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0000502	cellular_component	proteasome complex
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0031625	molecular_function	ubiquitin protein ligase binding
Q	0052548	biological_process	regulation of endopeptidase activity
R	0000502	cellular_component	proteasome complex
R	0000932	cellular_component	P-body
R	0003723	molecular_function	RNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005839	cellular_component	proteasome core complex
R	0005840	cellular_component	ribosome
R	0007519	biological_process	skeletal muscle tissue development
R	0016363	cellular_component	nuclear matrix
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0030016	cellular_component	myofibril
R	0030017	cellular_component	sarcomere
R	0051059	molecular_function	NF-kappaB binding
R	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
R	0051603	biological_process	proteolysis involved in protein catabolic process
S	0000502	cellular_component	proteasome complex
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005839	cellular_component	proteasome core complex
S	0019774	cellular_component	proteasome core complex, beta-subunit complex
T	0000502	cellular_component	proteasome complex
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005839	cellular_component	proteasome core complex
T	0014070	biological_process	response to organic cyclic compound
T	0019774	cellular_component	proteasome core complex, beta-subunit complex
U	0000502	cellular_component	proteasome complex
U	0004175	molecular_function	endopeptidase activity
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005839	cellular_component	proteasome core complex
U	0019774	cellular_component	proteasome core complex, beta-subunit complex
U	0030163	biological_process	protein catabolic process
V	0000502	cellular_component	proteasome complex
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0005839	cellular_component	proteasome core complex
V	0014070	biological_process	response to organic cyclic compound
V	0019774	cellular_component	proteasome core complex, beta-subunit complex
W	0000502	cellular_component	proteasome complex
W	0001530	molecular_function	lipopolysaccharide binding
W	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005739	cellular_component	mitochondrion
W	0005829	cellular_component	cytosol
W	0005839	cellular_component	proteasome core complex
W	0019774	cellular_component	proteasome core complex, beta-subunit complex
W	0036064	cellular_component	ciliary basal body
X	0000502	cellular_component	proteasome complex
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
Y	0000502	cellular_component	proteasome complex
Y	0004175	molecular_function	endopeptidase activity
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0005839	cellular_component	proteasome core complex
Y	0019774	cellular_component	proteasome core complex, beta-subunit complex
Y	0030163	biological_process	protein catabolic process
Z	0000502	cellular_component	proteasome complex
Z	0000932	cellular_component	P-body
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0005839	cellular_component	proteasome core complex
Z	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Z	0043231	cellular_component	intracellular membrane-bounded organelle

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdrgvNtFSPeGRlfQVEYAieA

Chain	Residue	Details
H	TYR8-ALA30
L	TYR6-ALA28
Q	TYR7-ALA29
P	TYR5-ALA27
I	TYR3-ALA25
O	TYR5-ALA27
R	PHE9-ALA31

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LAFkFlhGVIVAADsratagayiasqtvk.KvieinpyllgtmaGgaAD

Chain	Residue	Details
C	LEU4-ASP51
F	MET4-ASP51
B	ALA4-ASP51
U	MET11-ASP58
V	ILE5-ASP52
O	LEU35-ASP82
S	LEU13-ASP60
W	LEU12-ASP59

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0000250\|UniProtKB:P28070

Chain	Residue	Details
a	MET-44
W	MET-44
R	SER64
K	SER17
K	SER63
K	SER64

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P28070

Chain	Residue	Details
a	TYR57
W	TYR57
S	SER134
X	SER34
X	SER40
X	SER134

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:18034455

Chain	Residue	Details
S	TYR122
X	TYR122
J	LYS205
J	LYS229
b	SER13
b	SER15

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P20618

Chain	Residue	Details
S	LYS176
X	LYS176

site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269\|PubMed:22556278

Chain	Residue	Details
S	SER30
S	SER181
X	SER30
X	SER181
G	LYS208

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:18034455

Chain	Residue	Details
P	TYR75
b	TYR75

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P17220

Chain	Residue	Details
P	TYR120
b	TYR120

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:23806337

Chain	Residue	Details
P	LYS170
b	LYS170

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)