8YSX

canine immunoproteasome 20S subunit in complex with compound 2

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0005634	cellular_component	nucleus
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0005839	cellular_component	proteasome core complex
a	0019774	cellular_component	proteasome core complex, beta-subunit complex
a	0030163	biological_process	protein catabolic process
A	0000502	cellular_component	proteasome complex
A	0004175	molecular_function	endopeptidase activity
A	0004298	molecular_function	threonine-type endopeptidase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0019774	cellular_component	proteasome core complex, beta-subunit complex
A	0030163	biological_process	protein catabolic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
b	0000502	cellular_component	proteasome complex
b	0000932	cellular_component	P-body
b	0005634	cellular_component	nucleus
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005839	cellular_component	proteasome core complex
b	0006511	biological_process	ubiquitin-dependent protein catabolic process
b	0006979	biological_process	response to oxidative stress
b	0009615	biological_process	response to virus
b	0010498	biological_process	proteasomal protein catabolic process
b	0019773	cellular_component	proteasome core complex, alpha-subunit complex
b	0030163	biological_process	protein catabolic process
b	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
b	0061136	biological_process	regulation of proteasomal protein catabolic process
b	0140756	molecular_function	structural constituent of proteasome
B	0004298	molecular_function	threonine-type endopeptidase activity
B	0005839	cellular_component	proteasome core complex
B	0030163	biological_process	protein catabolic process
C	0004298	molecular_function	threonine-type endopeptidase activity
C	0005839	cellular_component	proteasome core complex
C	0030163	biological_process	protein catabolic process
D	0004298	molecular_function	threonine-type endopeptidase activity
D	0005839	cellular_component	proteasome core complex
D	0030163	biological_process	protein catabolic process
E	0004298	molecular_function	threonine-type endopeptidase activity
E	0005839	cellular_component	proteasome core complex
E	0030163	biological_process	protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0004175	molecular_function	endopeptidase activity
F	0004298	molecular_function	threonine-type endopeptidase activity
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005839	cellular_component	proteasome core complex
F	0019774	cellular_component	proteasome core complex, beta-subunit complex
F	0030163	biological_process	protein catabolic process
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030163	biological_process	protein catabolic process
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0000502	cellular_component	proteasome complex
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005839	cellular_component	proteasome core complex
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0006979	biological_process	response to oxidative stress
H	0010498	biological_process	proteasomal protein catabolic process
H	0019773	cellular_component	proteasome core complex, alpha-subunit complex
H	0030163	biological_process	protein catabolic process
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0061136	biological_process	regulation of proteasomal protein catabolic process
H	0140756	molecular_function	structural constituent of proteasome
I	0000502	cellular_component	proteasome complex
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005839	cellular_component	proteasome core complex
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0006979	biological_process	response to oxidative stress
I	0010498	biological_process	proteasomal protein catabolic process
I	0019773	cellular_component	proteasome core complex, alpha-subunit complex
I	0030163	biological_process	protein catabolic process
I	0042802	molecular_function	identical protein binding
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0061136	biological_process	regulation of proteasomal protein catabolic process
I	0140756	molecular_function	structural constituent of proteasome
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0019773	cellular_component	proteasome core complex, alpha-subunit complex
J	0030163	biological_process	protein catabolic process
K	0000502	cellular_component	proteasome complex
K	0003723	molecular_function	RNA binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005839	cellular_component	proteasome core complex
K	0005840	cellular_component	ribosome
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0006979	biological_process	response to oxidative stress
K	0010498	biological_process	proteasomal protein catabolic process
K	0019773	cellular_component	proteasome core complex, alpha-subunit complex
K	0030163	biological_process	protein catabolic process
K	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0050727	biological_process	regulation of inflammatory response
K	0051059	molecular_function	NF-kappaB binding
K	0061136	biological_process	regulation of proteasomal protein catabolic process
K	0097229	cellular_component	sperm end piece
K	0097542	cellular_component	ciliary tip
K	0140756	molecular_function	structural constituent of proteasome
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005839	cellular_component	proteasome core complex
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0019773	cellular_component	proteasome core complex, alpha-subunit complex
L	0030163	biological_process	protein catabolic process
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0000502	cellular_component	proteasome complex
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005839	cellular_component	proteasome core complex
M	0006511	biological_process	ubiquitin-dependent protein catabolic process
M	0006979	biological_process	response to oxidative stress
M	0010498	biological_process	proteasomal protein catabolic process
M	0019773	cellular_component	proteasome core complex, alpha-subunit complex
M	0030163	biological_process	protein catabolic process
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0061136	biological_process	regulation of proteasomal protein catabolic process
M	0140756	molecular_function	structural constituent of proteasome
N	0000502	cellular_component	proteasome complex
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005839	cellular_component	proteasome core complex
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0006979	biological_process	response to oxidative stress
N	0010498	biological_process	proteasomal protein catabolic process
N	0019773	cellular_component	proteasome core complex, alpha-subunit complex
N	0030163	biological_process	protein catabolic process
N	0042802	molecular_function	identical protein binding
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0061136	biological_process	regulation of proteasomal protein catabolic process
N	0140756	molecular_function	structural constituent of proteasome
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005839	cellular_component	proteasome core complex
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0030163	biological_process	protein catabolic process
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0000502	cellular_component	proteasome complex
P	0000932	cellular_component	P-body
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005839	cellular_component	proteasome core complex
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0006979	biological_process	response to oxidative stress
P	0009615	biological_process	response to virus
P	0010498	biological_process	proteasomal protein catabolic process
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0030163	biological_process	protein catabolic process
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0061136	biological_process	regulation of proteasomal protein catabolic process
P	0140756	molecular_function	structural constituent of proteasome
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0030163	biological_process	protein catabolic process
R	0000502	cellular_component	proteasome complex
R	0003723	molecular_function	RNA binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005839	cellular_component	proteasome core complex
R	0005840	cellular_component	ribosome
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0006979	biological_process	response to oxidative stress
R	0010498	biological_process	proteasomal protein catabolic process
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0030163	biological_process	protein catabolic process
R	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0050727	biological_process	regulation of inflammatory response
R	0051059	molecular_function	NF-kappaB binding
R	0061136	biological_process	regulation of proteasomal protein catabolic process
R	0097229	cellular_component	sperm end piece
R	0097542	cellular_component	ciliary tip
R	0140756	molecular_function	structural constituent of proteasome
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005839	cellular_component	proteasome core complex
S	0030163	biological_process	protein catabolic process
T	0000502	cellular_component	proteasome complex
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005839	cellular_component	proteasome core complex
T	0006979	biological_process	response to oxidative stress
T	0010498	biological_process	proteasomal protein catabolic process
T	0019774	cellular_component	proteasome core complex, beta-subunit complex
T	0030163	biological_process	protein catabolic process
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0061136	biological_process	regulation of proteasomal protein catabolic process
T	0140756	molecular_function	structural constituent of proteasome
U	0000502	cellular_component	proteasome complex
U	0005634	cellular_component	nucleus
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005839	cellular_component	proteasome core complex
U	0006979	biological_process	response to oxidative stress
U	0010498	biological_process	proteasomal protein catabolic process
U	0019774	cellular_component	proteasome core complex, beta-subunit complex
U	0030163	biological_process	protein catabolic process
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0061136	biological_process	regulation of proteasomal protein catabolic process
U	0140756	molecular_function	structural constituent of proteasome
V	0000502	cellular_component	proteasome complex
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0005839	cellular_component	proteasome core complex
V	0006979	biological_process	response to oxidative stress
V	0010498	biological_process	proteasomal protein catabolic process
V	0019774	cellular_component	proteasome core complex, beta-subunit complex
V	0030163	biological_process	protein catabolic process
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0061136	biological_process	regulation of proteasomal protein catabolic process
V	0140756	molecular_function	structural constituent of proteasome
W	0005634	cellular_component	nucleus
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005839	cellular_component	proteasome core complex
W	0019774	cellular_component	proteasome core complex, beta-subunit complex
W	0030163	biological_process	protein catabolic process
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0030163	biological_process	protein catabolic process
Y	0000502	cellular_component	proteasome complex
Y	0005634	cellular_component	nucleus
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0005839	cellular_component	proteasome core complex
Y	0006979	biological_process	response to oxidative stress
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0019774	cellular_component	proteasome core complex, beta-subunit complex
Y	0030163	biological_process	protein catabolic process
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0061136	biological_process	regulation of proteasomal protein catabolic process
Y	0140756	molecular_function	structural constituent of proteasome
Z	0005634	cellular_component	nucleus
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0005839	cellular_component	proteasome core complex
Z	0006511	biological_process	ubiquitin-dependent protein catabolic process
Z	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Z	0030163	biological_process	protein catabolic process
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YsfslTtFSPsGKlvQIEYAlaA

Chain	Residue	Details
P	TYR5-ALA27
O	TYR5-ALA27
L	TYR6-ALA28
J	TYR7-ALA29
R	PHE9-ALA31
M	TYR8-ALA30
N	TYR3-ALA25

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGIlAndGVLLAAErrnihklldevffse.KiyklnedmacsvaGitSD

Chain	Residue	Details
O	LEU35-ASP82
E	ALA4-ASP51
F	MET4-ASP51
T	ILE5-ASP52
C	LEU4-ASP51
S	LEU13-ASP60
a	LEU12-ASP59
U	MET11-ASP58

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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