8YS3

Crystal structure of rat thioredoxin, F54L mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009314	biological_process	response to radiation
A	0010269	biological_process	response to selenium ion
A	0014823	biological_process	response to activity
A	0015035	molecular_function	protein-disulfide reductase activity
A	0019725	biological_process	cellular homeostasis
A	0019899	molecular_function	enzyme binding
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0042803	molecular_function	protein homodimerization activity
A	0043025	cellular_component	neuronal cell body
A	0043388	biological_process	positive regulation of DNA binding
A	0045454	biological_process	cell redox homeostasis
A	0047134	molecular_function	protein-disulfide reductase [NAD(P)H] activity
A	0048678	biological_process	response to axon injury
A	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0055114	biological_process	obsolete oxidation-reduction process
A	0061692	biological_process	cellular detoxification of hydrogen peroxide
A	0071236	biological_process	cellular response to antibiotic
A	0071333	biological_process	cellular response to glucose stimulus
A	0071455	biological_process	cellular response to hyperoxia
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	0071548	biological_process	response to dexamethasone
A	0071731	biological_process	response to nitric oxide
A	0097068	biological_process	response to thyroxine
B	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009314	biological_process	response to radiation
B	0010269	biological_process	response to selenium ion
B	0014823	biological_process	response to activity
B	0015035	molecular_function	protein-disulfide reductase activity
B	0019725	biological_process	cellular homeostasis
B	0019899	molecular_function	enzyme binding
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0042803	molecular_function	protein homodimerization activity
B	0043025	cellular_component	neuronal cell body
B	0043388	biological_process	positive regulation of DNA binding
B	0045454	biological_process	cell redox homeostasis
B	0047134	molecular_function	protein-disulfide reductase [NAD(P)H] activity
B	0048678	biological_process	response to axon injury
B	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B	0055114	biological_process	obsolete oxidation-reduction process
B	0061692	biological_process	cellular detoxification of hydrogen peroxide
B	0071236	biological_process	cellular response to antibiotic
B	0071333	biological_process	cellular response to glucose stimulus
B	0071455	biological_process	cellular response to hyperoxia
B	0071466	biological_process	cellular response to xenobiotic stimulus
B	0071548	biological_process	response to dexamethasone
B	0071731	biological_process	response to nitric oxide
B	0097068	biological_process	response to thyroxine

Functional Information from PROSITE/UniProt

site_id	PS00194
Number of Residues	19
Details	THIOREDOXIN_1 Thioredoxin family active site. VVdFSatWCGPCKmIkpfF

Chain	Residue	Details
A	VAL24-PHE42

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	206
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Deprotonates C-terminal active site Cys","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Contributes to redox potential value","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P10599","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P10639","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"P10599","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"S-nitrosocysteine; alternate","evidences":[{"source":"UniProtKB","id":"P10599","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P10639","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---