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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8YQN

Torpedo acetylcholine receptor in complex with Erabutoxin A

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0016020cellular_componentmembrane
A0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
A0034220biological_processmonoatomic ion transmembrane transport
A0042391biological_processregulation of membrane potential
A0045211cellular_componentpostsynaptic membrane
A0060078biological_processregulation of postsynaptic membrane potential
A0060079biological_processexcitatory postsynaptic potential
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0016020cellular_componentmembrane
B0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
B0034220biological_processmonoatomic ion transmembrane transport
B0045211cellular_componentpostsynaptic membrane
B0060078biological_processregulation of postsynaptic membrane potential
B0060079biological_processexcitatory postsynaptic potential
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0016020cellular_componentmembrane
C0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
C0034220biological_processmonoatomic ion transmembrane transport
C0045211cellular_componentpostsynaptic membrane
C0060078biological_processregulation of postsynaptic membrane potential
C0060079biological_processexcitatory postsynaptic potential
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0016020cellular_componentmembrane
D0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
D0034220biological_processmonoatomic ion transmembrane transport
D0042391biological_processregulation of membrane potential
D0045211cellular_componentpostsynaptic membrane
D0060078biological_processregulation of postsynaptic membrane potential
D0060079biological_processexcitatory postsynaptic potential
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0016020cellular_componentmembrane
E0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
E0034220biological_processmonoatomic ion transmembrane transport
E0042391biological_processregulation of membrane potential
E0045211cellular_componentpostsynaptic membrane
E0060078biological_processregulation of postsynaptic membrane potential
E0060079biological_processexcitatory postsynaptic potential
E1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
F0005576cellular_componentextracellular region
F0030550molecular_functionacetylcholine receptor inhibitor activity
F0035821biological_processmodulation of process of another organism
F0090729molecular_functiontoxin activity
F0099106molecular_functionion channel regulator activity
G0005576cellular_componentextracellular region
G0030550molecular_functionacetylcholine receptor inhibitor activity
G0035821biological_processmodulation of process of another organism
G0090729molecular_functiontoxin activity
G0099106molecular_functionion channel regulator activity
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpIaVtyFPfDwqnC
ChainResidueDetails
ECYS128-CYS142
ACYS128-CYS142
CCYS128-CYS142
BCYS130-CYS144
site_idPS00272
Number of Residues19
DetailsSNAKE_TOXIN Snake toxins signature. GCg..CPtvkpgikls.CCesE
ChainResidueDetails
FGLY40-GLU58
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues635
DetailsTopological domain: {"description":"Extracellular"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues326
DetailsTransmembrane: {"description":"Helical"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"2742850","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6585820","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"2742850","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues215
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues81
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues28
DetailsRegion: {"description":"Loop I","evidences":[{"source":"PubMed","id":"7721859","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues10
DetailsRegion: {"description":"Stretch between loop I and loop II","evidences":[{"source":"PubMed","id":"7721859","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues34
DetailsRegion: {"description":"Loop II","evidences":[{"source":"PubMed","id":"7721859","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues22
DetailsRegion: {"description":"Loop III","evidences":[{"source":"PubMed","id":"7721859","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues6
DetailsSite: {"description":"Moderately important residue for binding to acetylcholine receptor","evidences":[{"source":"PubMed","id":"7721859","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues8
DetailsSite: {"description":"Very important residue for binding to acetylcholine receptor","evidences":[{"source":"PubMed","id":"7721859","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues6
DetailsSite: {"description":"Key residue for binding to acetylcholine receptor","evidences":[{"source":"PubMed","id":"7721859","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8419369","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsSite: {"description":"Key residue for binding to acetylcholine receptor","evidences":[{"source":"PubMed","id":"8419369","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues4
DetailsSite: {"description":"Very important residue for binding to acetylcholine receptor","evidences":[{"source":"PubMed","id":"8419369","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsSite: {"description":"Moderately important residue for binding to acetylcholine receptor","evidences":[{"source":"PubMed","id":"8419369","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

248335

PDB entries from 2026-01-28

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