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8YNM

Structure of the Caspase-8/cFLIP death effector domain assembly

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001817biological_processregulation of cytokine production
A0002682biological_processregulation of immune system process
A0004197molecular_functioncysteine-type endopeptidase activity
A0005123molecular_functiondeath receptor binding
A0005164molecular_functiontumor necrosis factor receptor binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0006915biological_processapoptotic process
A0007507biological_processheart development
A0008233molecular_functionpeptidase activity
A0008234molecular_functioncysteine-type peptidase activity
A0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
A0009967biological_processpositive regulation of signal transduction
A0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
A0016485biological_processprotein processing
A0016787molecular_functionhydrolase activity
A0030027cellular_componentlamellipodium
A0030101biological_processnatural killer cell activation
A0030154biological_processcell differentiation
A0030225biological_processmacrophage differentiation
A0030335biological_processpositive regulation of cell migration
A0031264cellular_componentdeath-inducing signaling complex
A0031265cellular_componentCD95 death-inducing signaling complex
A0031625molecular_functionubiquitin protein ligase binding
A0032025biological_processresponse to cobalt ion
A0032355biological_processresponse to estradiol
A0032496biological_processresponse to lipopolysaccharide
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032991cellular_componentprotein-containing complex
A0034612biological_processresponse to tumor necrosis factor
A0035877molecular_functiondeath effector domain binding
A0036462biological_processTRAIL-activated apoptotic signaling pathway
A0042110biological_processT cell activation
A0042113biological_processB cell activation
A0042802molecular_functionidentical protein binding
A0042981biological_processregulation of apoptotic process
A0043009biological_processchordate embryonic development
A0043065biological_processpositive regulation of apoptotic process
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
A0043525biological_processpositive regulation of neuron apoptotic process
A0044297cellular_componentcell body
A0044877molecular_functionprotein-containing complex binding
A0045088biological_processregulation of innate immune response
A0045471biological_processresponse to ethanol
A0045651biological_processpositive regulation of macrophage differentiation
A0045862biological_processpositive regulation of proteolysis
A0048513biological_processanimal organ development
A0051603biological_processproteolysis involved in protein catabolic process
A0051604biological_processprotein maturation
A0060546biological_processnegative regulation of necroptotic process
A0060715biological_processsyncytiotrophoblast cell differentiation involved in labyrinthine layer development
A0070269biological_processpyroptotic inflammatory response
A0071260biological_processcellular response to mechanical stimulus
A0072347biological_processresponse to anesthetic
A0097110molecular_functionscaffold protein binding
A0097190biological_processapoptotic signaling pathway
A0097191biological_processextrinsic apoptotic signaling pathway
A0097194biological_processexecution phase of apoptosis
A0097264biological_processself proteolysis
A0097342cellular_componentripoptosome
A1900119biological_processpositive regulation of execution phase of apoptosis
B0001525biological_processangiogenesis
B0001817biological_processregulation of cytokine production
B0002682biological_processregulation of immune system process
B0004197molecular_functioncysteine-type endopeptidase activity
B0005123molecular_functiondeath receptor binding
B0005164molecular_functiontumor necrosis factor receptor binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0006915biological_processapoptotic process
B0007507biological_processheart development
B0008233molecular_functionpeptidase activity
B0008234molecular_functioncysteine-type peptidase activity
B0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
B0009967biological_processpositive regulation of signal transduction
B0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
B0016485biological_processprotein processing
B0016787molecular_functionhydrolase activity
B0030027cellular_componentlamellipodium
B0030101biological_processnatural killer cell activation
B0030154biological_processcell differentiation
B0030225biological_processmacrophage differentiation
B0030335biological_processpositive regulation of cell migration
B0031264cellular_componentdeath-inducing signaling complex
B0031265cellular_componentCD95 death-inducing signaling complex
B0031625molecular_functionubiquitin protein ligase binding
B0032025biological_processresponse to cobalt ion
B0032355biological_processresponse to estradiol
B0032496biological_processresponse to lipopolysaccharide
B0032731biological_processpositive regulation of interleukin-1 beta production
B0032991cellular_componentprotein-containing complex
B0034612biological_processresponse to tumor necrosis factor
B0035877molecular_functiondeath effector domain binding
B0036462biological_processTRAIL-activated apoptotic signaling pathway
B0042110biological_processT cell activation
B0042113biological_processB cell activation
B0042802molecular_functionidentical protein binding
B0042981biological_processregulation of apoptotic process
B0043009biological_processchordate embryonic development
B0043065biological_processpositive regulation of apoptotic process
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
B0043525biological_processpositive regulation of neuron apoptotic process
B0044297cellular_componentcell body
B0044877molecular_functionprotein-containing complex binding
B0045088biological_processregulation of innate immune response
B0045471biological_processresponse to ethanol
B0045651biological_processpositive regulation of macrophage differentiation
B0045862biological_processpositive regulation of proteolysis
B0048513biological_processanimal organ development
B0051603biological_processproteolysis involved in protein catabolic process
B0051604biological_processprotein maturation
B0060546biological_processnegative regulation of necroptotic process
B0060715biological_processsyncytiotrophoblast cell differentiation involved in labyrinthine layer development
B0070269biological_processpyroptotic inflammatory response
B0071260biological_processcellular response to mechanical stimulus
B0072347biological_processresponse to anesthetic
B0097110molecular_functionscaffold protein binding
B0097190biological_processapoptotic signaling pathway
B0097191biological_processextrinsic apoptotic signaling pathway
B0097194biological_processexecution phase of apoptosis
B0097264biological_processself proteolysis
B0097342cellular_componentripoptosome
B1900119biological_processpositive regulation of execution phase of apoptosis
C0001525biological_processangiogenesis
C0001817biological_processregulation of cytokine production
C0002682biological_processregulation of immune system process
C0004197molecular_functioncysteine-type endopeptidase activity
C0005123molecular_functiondeath receptor binding
C0005164molecular_functiontumor necrosis factor receptor binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005741cellular_componentmitochondrial outer membrane
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0006508biological_processproteolysis
C0006915biological_processapoptotic process
C0007507biological_processheart development
C0008233molecular_functionpeptidase activity
C0008234molecular_functioncysteine-type peptidase activity
C0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
C0009967biological_processpositive regulation of signal transduction
C0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
C0016485biological_processprotein processing
C0016787molecular_functionhydrolase activity
C0030027cellular_componentlamellipodium
C0030101biological_processnatural killer cell activation
C0030154biological_processcell differentiation
C0030225biological_processmacrophage differentiation
C0030335biological_processpositive regulation of cell migration
C0031264cellular_componentdeath-inducing signaling complex
C0031265cellular_componentCD95 death-inducing signaling complex
C0031625molecular_functionubiquitin protein ligase binding
C0032025biological_processresponse to cobalt ion
C0032355biological_processresponse to estradiol
C0032496biological_processresponse to lipopolysaccharide
C0032731biological_processpositive regulation of interleukin-1 beta production
C0032991cellular_componentprotein-containing complex
C0034612biological_processresponse to tumor necrosis factor
C0035877molecular_functiondeath effector domain binding
C0036462biological_processTRAIL-activated apoptotic signaling pathway
C0042110biological_processT cell activation
C0042113biological_processB cell activation
C0042802molecular_functionidentical protein binding
C0042981biological_processregulation of apoptotic process
C0043009biological_processchordate embryonic development
C0043065biological_processpositive regulation of apoptotic process
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
C0043525biological_processpositive regulation of neuron apoptotic process
C0044297cellular_componentcell body
C0044877molecular_functionprotein-containing complex binding
C0045088biological_processregulation of innate immune response
C0045471biological_processresponse to ethanol
C0045651biological_processpositive regulation of macrophage differentiation
C0045862biological_processpositive regulation of proteolysis
C0048513biological_processanimal organ development
C0051603biological_processproteolysis involved in protein catabolic process
C0051604biological_processprotein maturation
C0060546biological_processnegative regulation of necroptotic process
C0060715biological_processsyncytiotrophoblast cell differentiation involved in labyrinthine layer development
C0070269biological_processpyroptotic inflammatory response
C0071260biological_processcellular response to mechanical stimulus
C0072347biological_processresponse to anesthetic
C0097110molecular_functionscaffold protein binding
C0097190biological_processapoptotic signaling pathway
C0097191biological_processextrinsic apoptotic signaling pathway
C0097194biological_processexecution phase of apoptosis
C0097264biological_processself proteolysis
C0097342cellular_componentripoptosome
C1900119biological_processpositive regulation of execution phase of apoptosis
F0042981biological_processregulation of apoptotic process
G0042981biological_processregulation of apoptotic process
H0042981biological_processregulation of apoptotic process
I0042981biological_processregulation of apoptotic process
J0042981biological_processregulation of apoptotic process
K0042981biological_processregulation of apoptotic process
N0042981biological_processregulation of apoptotic process
O0042981biological_processregulation of apoptotic process
Functional Information from PROSITE/UniProt
site_idPS01121
Number of Residues15
DetailsCASPASE_HIS Caspase family histidine active site. HsnmdCfiCcILSHG
ChainResidueDetails
AHIS304-GLY318

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues666
DetailsDomain: {"description":"DED 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00065","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues699
DetailsDomain: {"description":"DED 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00065","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idMCSA1
Number of Residues
DetailsM-CSA 818
ChainResidueDetails

site_idMCSA2
Number of Residues
DetailsM-CSA 818
ChainResidueDetails

site_idMCSA3
Number of Residues
DetailsM-CSA 818
ChainResidueDetails

246905

PDB entries from 2025-12-31

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