8YNF

Structure of Duffy Antigen Receptor for Chemokines (DARC)/ACKR1 in complex with the chemokine, CXCL8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005769	cellular_component	early endosome
A	0005886	cellular_component	plasma membrane
A	0006952	biological_process	defense response
A	0006954	biological_process	inflammatory response
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
A	0019957	molecular_function	C-C chemokine binding
A	0032642	biological_process	regulation of chemokine production
A	0038023	molecular_function	signaling receptor activity
A	0055037	cellular_component	recycling endosome
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0004930	molecular_function	G protein-coupled receptor activity
B	0005769	cellular_component	early endosome
B	0005886	cellular_component	plasma membrane
B	0006952	biological_process	defense response
B	0006954	biological_process	inflammatory response
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0016020	cellular_component	membrane
B	0019957	molecular_function	C-C chemokine binding
B	0032642	biological_process	regulation of chemokine production
B	0038023	molecular_function	signaling receptor activity
B	0055037	cellular_component	recycling endosome
D	0001525	biological_process	angiogenesis
D	0002237	biological_process	response to molecule of bacterial origin
D	0005125	molecular_function	cytokine activity
D	0005153	molecular_function	interleukin-8 receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006935	biological_process	chemotaxis
D	0006954	biological_process	inflammatory response
D	0007165	biological_process	signal transduction
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
D	0008009	molecular_function	chemokine activity
D	0008201	molecular_function	heparin binding
D	0008285	biological_process	negative regulation of cell population proliferation
D	0010628	biological_process	positive regulation of gene expression
D	0010629	biological_process	negative regulation of gene expression
D	0016020	cellular_component	membrane
D	0019722	biological_process	calcium-mediated signaling
D	0030155	biological_process	regulation of cell adhesion
D	0030593	biological_process	neutrophil chemotaxis
D	0031623	biological_process	receptor internalization
D	0032642	biological_process	regulation of chemokine production
D	0034976	biological_process	response to endoplasmic reticulum stress
D	0035556	biological_process	intracellular signal transduction
D	0042119	biological_process	neutrophil activation
D	0044344	biological_process	cellular response to fibroblast growth factor stimulus
D	0045091	biological_process	regulation of single stranded viral RNA replication via double stranded DNA intermediate
D	0045236	molecular_function	CXCR chemokine receptor binding
D	0045730	biological_process	respiratory burst
D	0045744	biological_process	negative regulation of G protein-coupled receptor signaling pathway
D	0045766	biological_process	positive regulation of angiogenesis
D	0048566	biological_process	embryonic digestive tract development
D	0050920	biological_process	regulation of chemotaxis
D	0050930	biological_process	induction of positive chemotaxis
D	0060354	biological_process	negative regulation of cell adhesion molecule production
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
D	0071222	biological_process	cellular response to lipopolysaccharide
D	0071347	biological_process	cellular response to interleukin-1
D	0071356	biological_process	cellular response to tumor necrosis factor
D	0090023	biological_process	positive regulation of neutrophil chemotaxis
D	2000535	biological_process	regulation of entry of bacterium into host cell
E	0001525	biological_process	angiogenesis
E	0002237	biological_process	response to molecule of bacterial origin
E	0005125	molecular_function	cytokine activity
E	0005153	molecular_function	interleukin-8 receptor binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006935	biological_process	chemotaxis
E	0006954	biological_process	inflammatory response
E	0007165	biological_process	signal transduction
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
E	0008009	molecular_function	chemokine activity
E	0008201	molecular_function	heparin binding
E	0008285	biological_process	negative regulation of cell population proliferation
E	0010628	biological_process	positive regulation of gene expression
E	0010629	biological_process	negative regulation of gene expression
E	0016020	cellular_component	membrane
E	0019722	biological_process	calcium-mediated signaling
E	0030155	biological_process	regulation of cell adhesion
E	0030593	biological_process	neutrophil chemotaxis
E	0031623	biological_process	receptor internalization
E	0032642	biological_process	regulation of chemokine production
E	0034976	biological_process	response to endoplasmic reticulum stress
E	0035556	biological_process	intracellular signal transduction
E	0042119	biological_process	neutrophil activation
E	0044344	biological_process	cellular response to fibroblast growth factor stimulus
E	0045091	biological_process	regulation of single stranded viral RNA replication via double stranded DNA intermediate
E	0045236	molecular_function	CXCR chemokine receptor binding
E	0045730	biological_process	respiratory burst
E	0045744	biological_process	negative regulation of G protein-coupled receptor signaling pathway
E	0045766	biological_process	positive regulation of angiogenesis
E	0048566	biological_process	embryonic digestive tract development
E	0050920	biological_process	regulation of chemotaxis
E	0050930	biological_process	induction of positive chemotaxis
E	0060354	biological_process	negative regulation of cell adhesion molecule production
E	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
E	0071222	biological_process	cellular response to lipopolysaccharide
E	0071347	biological_process	cellular response to interleukin-1
E	0071356	biological_process	cellular response to tumor necrosis factor
E	0090023	biological_process	positive regulation of neutrophil chemotaxis
E	2000535	biological_process	regulation of entry of bacterium into host cell
G	0001525	biological_process	angiogenesis
G	0002237	biological_process	response to molecule of bacterial origin
G	0005125	molecular_function	cytokine activity
G	0005153	molecular_function	interleukin-8 receptor binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0006935	biological_process	chemotaxis
G	0006954	biological_process	inflammatory response
G	0007165	biological_process	signal transduction
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
G	0008009	molecular_function	chemokine activity
G	0008201	molecular_function	heparin binding
G	0008285	biological_process	negative regulation of cell population proliferation
G	0010628	biological_process	positive regulation of gene expression
G	0010629	biological_process	negative regulation of gene expression
G	0016020	cellular_component	membrane
G	0019722	biological_process	calcium-mediated signaling
G	0030155	biological_process	regulation of cell adhesion
G	0030593	biological_process	neutrophil chemotaxis
G	0031623	biological_process	receptor internalization
G	0032642	biological_process	regulation of chemokine production
G	0034976	biological_process	response to endoplasmic reticulum stress
G	0035556	biological_process	intracellular signal transduction
G	0042119	biological_process	neutrophil activation
G	0044344	biological_process	cellular response to fibroblast growth factor stimulus
G	0045091	biological_process	regulation of single stranded viral RNA replication via double stranded DNA intermediate
G	0045236	molecular_function	CXCR chemokine receptor binding
G	0045730	biological_process	respiratory burst
G	0045744	biological_process	negative regulation of G protein-coupled receptor signaling pathway
G	0045766	biological_process	positive regulation of angiogenesis
G	0048566	biological_process	embryonic digestive tract development
G	0050920	biological_process	regulation of chemotaxis
G	0050930	biological_process	induction of positive chemotaxis
G	0060354	biological_process	negative regulation of cell adhesion molecule production
G	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
G	0071222	biological_process	cellular response to lipopolysaccharide
G	0071347	biological_process	cellular response to interleukin-1
G	0071356	biological_process	cellular response to tumor necrosis factor
G	0090023	biological_process	positive regulation of neutrophil chemotaxis
G	2000535	biological_process	regulation of entry of bacterium into host cell
H	0001525	biological_process	angiogenesis
H	0002237	biological_process	response to molecule of bacterial origin
H	0005125	molecular_function	cytokine activity
H	0005153	molecular_function	interleukin-8 receptor binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0006935	biological_process	chemotaxis
H	0006954	biological_process	inflammatory response
H	0007165	biological_process	signal transduction
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
H	0008009	molecular_function	chemokine activity
H	0008201	molecular_function	heparin binding
H	0008285	biological_process	negative regulation of cell population proliferation
H	0010628	biological_process	positive regulation of gene expression
H	0010629	biological_process	negative regulation of gene expression
H	0016020	cellular_component	membrane
H	0019722	biological_process	calcium-mediated signaling
H	0030155	biological_process	regulation of cell adhesion
H	0030593	biological_process	neutrophil chemotaxis
H	0031623	biological_process	receptor internalization
H	0032642	biological_process	regulation of chemokine production
H	0034976	biological_process	response to endoplasmic reticulum stress
H	0035556	biological_process	intracellular signal transduction
H	0042119	biological_process	neutrophil activation
H	0044344	biological_process	cellular response to fibroblast growth factor stimulus
H	0045091	biological_process	regulation of single stranded viral RNA replication via double stranded DNA intermediate
H	0045236	molecular_function	CXCR chemokine receptor binding
H	0045730	biological_process	respiratory burst
H	0045744	biological_process	negative regulation of G protein-coupled receptor signaling pathway
H	0045766	biological_process	positive regulation of angiogenesis
H	0048566	biological_process	embryonic digestive tract development
H	0050920	biological_process	regulation of chemotaxis
H	0050930	biological_process	induction of positive chemotaxis
H	0060354	biological_process	negative regulation of cell adhesion molecule production
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
H	0071222	biological_process	cellular response to lipopolysaccharide
H	0071347	biological_process	cellular response to interleukin-1
H	0071356	biological_process	cellular response to tumor necrosis factor
H	0090023	biological_process	positive regulation of neutrophil chemotaxis
H	2000535	biological_process	regulation of entry of bacterium into host cell

Functional Information from PROSITE/UniProt

site_id	PS00471
Number of Residues	46
Details	SMALL_CYTOKINES_CXC Small cytokines (intercrine/chemokine) C-x-C subfamily signature. CqCIktyskpFhpKfIkeLrviesGphCantEIIvklsdgrel.CLD

Chain	Residue	Details
D	CYS7-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	104
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---