8YN2
Cryo-EM structure of histamine H1 receptor in complex with histamine and miniGq
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIfSVFILCIDRYRsV |
| Chain | Residue | Details |
| R | ALA113-VAL129 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| B | LEU70-SER84 | |
| B | ILE157-ILE171 | |
| B | LEU285-ALA299 | |
| B | VAL327-GLY341 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 63 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:21697825 |
| Chain | Residue | Details |
| R | MET1-PRO29 | |
| R | MET90-ARG97 | |
| R | TRP165-THR188 | |
| R | CYS441-ASN446 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL |
| Chain | Residue | Details |
| R | LEU30-TYR50 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 254 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:21697825 |
| Chain | Residue | Details |
| R | ALA51-LEU64 | |
| R | ASP124-ALA144 | |
| R | LYS212-GLN416 | |
| R | LEU470-SER487 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL |
| Chain | Residue | Details |
| R | TYR65-LEU89 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL |
| Chain | Residue | Details |
| R | PRO98-ILE123 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL |
| Chain | Residue | Details |
| R | SER145-GLY164 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL |
| Chain | Residue | Details |
| R | TRP189-ALA211 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL |
| Chain | Residue | Details |
| R | LEU417-PHE440 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000305|PubMed:33828102, ECO:0007744|PDB:7DFL |
| Chain | Residue | Details |
| R | GLU447-PRO469 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:33828102 |
| Chain | Residue | Details |
| R | ASP107 | |
| R | ASN198 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33828102, ECO:0007744|PDB:7DFL |
| Chain | Residue | Details |
| R | THR112 | |
| R | TYR431 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:15328002 |
| Chain | Residue | Details |
| R | THR140 | |
| R | THR142 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| R | SER230 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| R | THR279 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P70174 |
| Chain | Residue | Details |
| R | SER344 | |
| R | SER347 | |
| R | SER380 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:15328002 |
| Chain | Residue | Details |
| R | SER396 | |
| R | SER398 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| R | ASN5 | |
| R | ASN18 |
