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8YJS

Structure of the human endogenous PCNA-FEN1 complex - State E

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
A0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0001673cellular_componentmale germ cell nucleus
A0003677molecular_functionDNA binding
A0003682molecular_functionchromatin binding
A0003684molecular_functiondamaged DNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005652cellular_componentnuclear lamina
A0005654cellular_componentnucleoplasm
A0005657cellular_componentreplication fork
A0005813cellular_componentcentrosome
A0006260biological_processDNA replication
A0006272biological_processleading strand elongation
A0006275biological_processregulation of DNA replication
A0006281biological_processDNA repair
A0006287biological_processbase-excision repair, gap-filling
A0006298biological_processmismatch repair
A0006325biological_processchromatin organization
A0006974biological_processDNA damage response
A0006979biological_processresponse to oxidative stress
A0007507biological_processheart development
A0016604cellular_componentnuclear body
A0019899molecular_functionenzyme binding
A0019985biological_processtranslesion synthesis
A0030331molecular_functionnuclear estrogen receptor binding
A0030337molecular_functionDNA polymerase processivity factor activity
A0030855biological_processepithelial cell differentiation
A0030894cellular_componentreplisome
A0030971molecular_functionreceptor tyrosine kinase binding
A0031297biological_processreplication fork processing
A0032077biological_processpositive regulation of deoxyribonuclease activity
A0032139molecular_functiondinucleotide insertion or deletion binding
A0032355biological_processresponse to estradiol
A0032405molecular_functionMutLalpha complex binding
A0033993biological_processresponse to lipid
A0034644biological_processcellular response to UV
A0035035molecular_functionhistone acetyltransferase binding
A0042802molecular_functionidentical protein binding
A0043596cellular_componentnuclear replication fork
A0043626cellular_componentPCNA complex
A0044849biological_processestrous cycle
A0044877molecular_functionprotein-containing complex binding
A0045739biological_processpositive regulation of DNA repair
A0045740biological_processpositive regulation of DNA replication
A0046686biological_processresponse to cadmium ion
A0070062cellular_componentextracellular exosome
A0070182molecular_functionDNA polymerase binding
A0070301biological_processcellular response to hydrogen peroxide
A0070557cellular_componentPCNA-p21 complex
A0071466biological_processcellular response to xenobiotic stimulus
A0071548biological_processresponse to dexamethasone
A0097421biological_processliver regeneration
A1900264biological_processpositive regulation of DNA-directed DNA polymerase activity
A1902065biological_processresponse to L-glutamate
A1902990biological_processmitotic telomere maintenance via semi-conservative replication
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
B0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
B0000781cellular_componentchromosome, telomeric region
B0000785cellular_componentchromatin
B0001673cellular_componentmale germ cell nucleus
B0003677molecular_functionDNA binding
B0003682molecular_functionchromatin binding
B0003684molecular_functiondamaged DNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005652cellular_componentnuclear lamina
B0005654cellular_componentnucleoplasm
B0005657cellular_componentreplication fork
B0005813cellular_componentcentrosome
B0006260biological_processDNA replication
B0006272biological_processleading strand elongation
B0006275biological_processregulation of DNA replication
B0006281biological_processDNA repair
B0006287biological_processbase-excision repair, gap-filling
B0006298biological_processmismatch repair
B0006325biological_processchromatin organization
B0006974biological_processDNA damage response
B0006979biological_processresponse to oxidative stress
B0007507biological_processheart development
B0016604cellular_componentnuclear body
B0019899molecular_functionenzyme binding
B0019985biological_processtranslesion synthesis
B0030331molecular_functionnuclear estrogen receptor binding
B0030337molecular_functionDNA polymerase processivity factor activity
B0030855biological_processepithelial cell differentiation
B0030894cellular_componentreplisome
B0030971molecular_functionreceptor tyrosine kinase binding
B0031297biological_processreplication fork processing
B0032077biological_processpositive regulation of deoxyribonuclease activity
B0032139molecular_functiondinucleotide insertion or deletion binding
B0032355biological_processresponse to estradiol
B0032405molecular_functionMutLalpha complex binding
B0033993biological_processresponse to lipid
B0034644biological_processcellular response to UV
B0035035molecular_functionhistone acetyltransferase binding
B0042802molecular_functionidentical protein binding
B0043596cellular_componentnuclear replication fork
B0043626cellular_componentPCNA complex
B0044849biological_processestrous cycle
B0044877molecular_functionprotein-containing complex binding
B0045739biological_processpositive regulation of DNA repair
B0045740biological_processpositive regulation of DNA replication
B0046686biological_processresponse to cadmium ion
B0070062cellular_componentextracellular exosome
B0070182molecular_functionDNA polymerase binding
B0070301biological_processcellular response to hydrogen peroxide
B0070557cellular_componentPCNA-p21 complex
B0071466biological_processcellular response to xenobiotic stimulus
B0071548biological_processresponse to dexamethasone
B0097421biological_processliver regeneration
B1900264biological_processpositive regulation of DNA-directed DNA polymerase activity
B1902065biological_processresponse to L-glutamate
B1902990biological_processmitotic telomere maintenance via semi-conservative replication
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
C0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
C0000781cellular_componentchromosome, telomeric region
C0000785cellular_componentchromatin
C0001673cellular_componentmale germ cell nucleus
C0003677molecular_functionDNA binding
C0003682molecular_functionchromatin binding
C0003684molecular_functiondamaged DNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005652cellular_componentnuclear lamina
C0005654cellular_componentnucleoplasm
C0005657cellular_componentreplication fork
C0005813cellular_componentcentrosome
C0006260biological_processDNA replication
C0006272biological_processleading strand elongation
C0006275biological_processregulation of DNA replication
C0006281biological_processDNA repair
C0006287biological_processbase-excision repair, gap-filling
C0006298biological_processmismatch repair
C0006325biological_processchromatin organization
C0006974biological_processDNA damage response
C0006979biological_processresponse to oxidative stress
C0007507biological_processheart development
C0016604cellular_componentnuclear body
C0019899molecular_functionenzyme binding
C0019985biological_processtranslesion synthesis
C0030331molecular_functionnuclear estrogen receptor binding
C0030337molecular_functionDNA polymerase processivity factor activity
C0030855biological_processepithelial cell differentiation
C0030894cellular_componentreplisome
C0030971molecular_functionreceptor tyrosine kinase binding
C0031297biological_processreplication fork processing
C0032077biological_processpositive regulation of deoxyribonuclease activity
C0032139molecular_functiondinucleotide insertion or deletion binding
C0032355biological_processresponse to estradiol
C0032405molecular_functionMutLalpha complex binding
C0033993biological_processresponse to lipid
C0034644biological_processcellular response to UV
C0035035molecular_functionhistone acetyltransferase binding
C0042802molecular_functionidentical protein binding
C0043596cellular_componentnuclear replication fork
C0043626cellular_componentPCNA complex
C0044849biological_processestrous cycle
C0044877molecular_functionprotein-containing complex binding
C0045739biological_processpositive regulation of DNA repair
C0045740biological_processpositive regulation of DNA replication
C0046686biological_processresponse to cadmium ion
C0070062cellular_componentextracellular exosome
C0070182molecular_functionDNA polymerase binding
C0070301biological_processcellular response to hydrogen peroxide
C0070557cellular_componentPCNA-p21 complex
C0071466biological_processcellular response to xenobiotic stimulus
C0071548biological_processresponse to dexamethasone
C0097421biological_processliver regeneration
C1900264biological_processpositive regulation of DNA-directed DNA polymerase activity
C1902065biological_processresponse to L-glutamate
C1902990biological_processmitotic telomere maintenance via semi-conservative replication
D0000287molecular_functionmagnesium ion binding
D0000724biological_processdouble-strand break repair via homologous recombination
D0000781cellular_componentchromosome, telomeric region
D0003677molecular_functionDNA binding
D0003684molecular_functiondamaged DNA binding
D0003690molecular_functiondouble-stranded DNA binding
D0003824molecular_functioncatalytic activity
D0004518molecular_functionnuclease activity
D0004519molecular_functionendonuclease activity
D0004520molecular_functionDNA endonuclease activity
D0004523molecular_functionRNA-DNA hybrid ribonuclease activity
D0004527molecular_functionexonuclease activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005739cellular_componentmitochondrion
D0006260biological_processDNA replication
D0006281biological_processDNA repair
D0006284biological_processbase-excision repair
D0006287biological_processbase-excision repair, gap-filling
D0006302biological_processdouble-strand break repair
D0006310biological_processDNA recombination
D0006974biological_processDNA damage response
D0007613biological_processmemory
D0008309molecular_functiondouble-stranded DNA exodeoxyribonuclease activity
D0008409molecular_function5'-3' exonuclease activity
D0009650biological_processUV protection
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0016788molecular_functionhydrolase activity, acting on ester bonds
D0017108molecular_function5'-flap endonuclease activity
D0030145molecular_functionmanganese ion binding
D0032201biological_processtelomere maintenance via semi-conservative replication
D0032991cellular_componentprotein-containing complex
D0043137biological_processDNA replication, removal of RNA primer
D0045876biological_processpositive regulation of sister chromatid cohesion
D0046872molecular_functionmetal ion binding
D0048256molecular_functionflap endonuclease activity
Functional Information from PROSITE/UniProt
site_idPS00293
Number of Residues19
DetailsPCNA_2 Proliferating cell nuclear antigen signature 2. RCDRnlaMgvnLtSMsKIL
ChainResidueDetails
CARG61-LEU79

site_idPS00841
Number of Residues15
DetailsXPG_1 XPG protein signature 1. IKPvYVFDGkpPqLK
ChainResidueDetails
DILE79-LYS93

site_idPS00842
Number of Residues15
DetailsXPG_2 XPG protein signature 2. GIPYLdAPsEAEASC
ChainResidueDetails
DGLY149-CYS163

site_idPS01251
Number of Residues24
DetailsPCNA_1 Proliferating cell nuclear antigen signature 1. GVnLqSMDsSHVsLVqLtLrsegF
ChainResidueDetails
CGLY34-PHE57

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:15616578, ECO:0007744|PDB:1UL1
ChainResidueDetails
DASP34
BARG61-LYS80
AARG61-LYS80

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING:
ChainResidueDetails
DARG47
DARG70
DGLY231

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:15616578, ECO:0007744|PDB:1UL1, ECO:0007744|PDB:5FV7
ChainResidueDetails
DASP86
DGLU158
CLYS248
BLYS77
BLYS80
BLYS248
ALYS77
ALYS80
ALYS248

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:15616578, ECO:0007744|PDB:1UL1, ECO:0007744|PDB:5FV7, ECO:0007744|PDB:5ZOD
ChainResidueDetails
DGLU160
DASP181
ATYR211

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:5FV7, ECO:0007744|PDB:5ZOD
ChainResidueDetails
DASP179
BLYS164
ALYS164

site_idSWS_FT_FI6
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:5ZOD
ChainResidueDetails
DASP233
CLYS254
BLYS254
ALYS254

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Symmetric dimethylarginine; by PRMT5 => ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:20729856
ChainResidueDetails
DARG19
DARG100
DARG104
DARG192

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
DLYS80

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK2 => ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:20729856
ChainResidueDetails
DSER187

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
DSER197

site_idSWS_FT_FI11
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER255
DSER293
DSER335

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
DTHR336

site_idSWS_FT_FI13
Number of Residues3
DetailsMOD_RES: N6-acetyllysine => ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:11430825
ChainResidueDetails
DLYS354
DLYS377
DLYS380

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231
ChainResidueDetails
DTHR364

site_idSWS_FT_FI15
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:11430825, ECO:0007744|PubMed:19608861
ChainResidueDetails
DLYS375

237423

PDB entries from 2025-06-11

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