Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8YHQ

Cryo-EM structure of Saccharomyces cerevisiae bc1 complex in pyraclostrobin-bound state

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
A	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
A	0008121	molecular_function	quinol-cytochrome-c reductase activity
A	0009060	biological_process	aerobic respiration
A	0016020	cellular_component	membrane
A	0045275	cellular_component	respiratory chain complex III
A	0045333	biological_process	cellular respiration
A	0046872	molecular_function	metal ion binding
A	1902600	biological_process	proton transmembrane transport
B	0004222	molecular_function	metalloendopeptidase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0006508	biological_process	proteolysis
B	0008121	molecular_function	quinol-cytochrome-c reductase activity
B	0009060	biological_process	aerobic respiration
B	0016020	cellular_component	membrane
B	0030061	cellular_component	mitochondrial crista
B	0045275	cellular_component	respiratory chain complex III
B	0045333	biological_process	cellular respiration
B	0046872	molecular_function	metal ion binding
B	1902600	biological_process	proton transmembrane transport
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0008121	molecular_function	quinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0009060	biological_process	aerobic respiration
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0022904	biological_process	respiratory electron transport chain
C	0045275	cellular_component	respiratory chain complex III
C	0045333	biological_process	cellular respiration
C	0046872	molecular_function	metal ion binding
C	1902600	biological_process	proton transmembrane transport
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
E	0008121	molecular_function	quinol-cytochrome-c reductase activity
E	0016020	cellular_component	membrane
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0008121	molecular_function	quinol-cytochrome-c reductase activity
G	0009060	biological_process	aerobic respiration
G	0016020	cellular_component	membrane
G	0034551	biological_process	mitochondrial respiratory chain complex III assembly
G	0045275	cellular_component	respiratory chain complex III
G	0045333	biological_process	cellular respiration
G	0099617	cellular_component	matrix side of mitochondrial inner membrane
G	1902600	biological_process	proton transmembrane transport
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0008121	molecular_function	quinol-cytochrome-c reductase activity
H	0009060	biological_process	aerobic respiration
H	0016020	cellular_component	membrane
H	0045275	cellular_component	respiratory chain complex III
H	0045333	biological_process	cellular respiration
H	1902600	biological_process	proton transmembrane transport
I	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
I	0045275	cellular_component	respiratory chain complex III
J	0004222	molecular_function	metalloendopeptidase activity
J	0005515	molecular_function	protein binding
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
J	0008121	molecular_function	quinol-cytochrome-c reductase activity
J	0009060	biological_process	aerobic respiration
J	0016020	cellular_component	membrane
J	0045275	cellular_component	respiratory chain complex III
J	0045333	biological_process	cellular respiration
J	0046872	molecular_function	metal ion binding
J	1902600	biological_process	proton transmembrane transport
K	0004222	molecular_function	metalloendopeptidase activity
K	0005515	molecular_function	protein binding
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
K	0006508	biological_process	proteolysis
K	0008121	molecular_function	quinol-cytochrome-c reductase activity
K	0009060	biological_process	aerobic respiration
K	0016020	cellular_component	membrane
K	0030061	cellular_component	mitochondrial crista
K	0045275	cellular_component	respiratory chain complex III
K	0045333	biological_process	cellular respiration
K	0046872	molecular_function	metal ion binding
K	1902600	biological_process	proton transmembrane transport
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
L	0008121	molecular_function	quinol-cytochrome-c reductase activity
L	0009055	molecular_function	electron transfer activity
L	0009060	biological_process	aerobic respiration
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
L	0022904	biological_process	respiratory electron transport chain
L	0045275	cellular_component	respiratory chain complex III
L	0045333	biological_process	cellular respiration
L	0046872	molecular_function	metal ion binding
L	1902600	biological_process	proton transmembrane transport
M	0009055	molecular_function	electron transfer activity
M	0020037	molecular_function	heme binding
N	0008121	molecular_function	quinol-cytochrome-c reductase activity
N	0016020	cellular_component	membrane
N	0051537	molecular_function	2 iron, 2 sulfur cluster binding
O	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
P	0008121	molecular_function	quinol-cytochrome-c reductase activity
P	0009060	biological_process	aerobic respiration
P	0016020	cellular_component	membrane
P	0034551	biological_process	mitochondrial respiratory chain complex III assembly
P	0045275	cellular_component	respiratory chain complex III
P	0045333	biological_process	cellular respiration
P	0099617	cellular_component	matrix side of mitochondrial inner membrane
P	1902600	biological_process	proton transmembrane transport
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Q	0008121	molecular_function	quinol-cytochrome-c reductase activity
Q	0009060	biological_process	aerobic respiration
Q	0016020	cellular_component	membrane
Q	0045275	cellular_component	respiratory chain complex III
Q	0045333	biological_process	cellular respiration
Q	1902600	biological_process	proton transmembrane transport
R	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
R	0045275	cellular_component	respiratory chain complex III
S	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
T	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c

Functional Information from PROSITE/UniProt

site_id	PS00143
Number of Residues	23
Details	INSULINASE Insulinase family, zinc-binding region signature. Ggsryatkd.GvAHLLNRFnFqNT

Chain	Residue	Details
B	GLY37-THR59

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	94
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000269\|PubMed:18390544, ECO:0000269\|PubMed:30598554

Chain	Residue	Details
H	GLY2-PHE49
L	ILE365-LYS385
Q	GLY2-PHE49
C	GLY205-SER223
C	ASP309-LYS319
C	ILE365-LYS385
L	MET1-ASN27
L	TYR103-ARG110
L	GLY205-SER223
L	ASP309-LYS319

site_id	SWS_FT_FI2
Number of Residues	60
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:18390544, ECO:0000269\|PubMed:30598554

Chain	Residue	Details
H	ARG50-LEU80
L	GLY75-TYR102
L	VAL111-VAL135
L	ASN173-HIS204
L	TYR224-TYR246
L	LYS288-THR308
L	VAL320-GLY340
L	TYR348-LEU364
Q	ARG50-LEU80
C	VAL111-VAL135
C	ASN173-HIS204
C	TYR224-TYR246
C	LYS288-THR308
C	VAL320-GLY340
C	TYR348-LEU364
L	TYR28-ALA51

site_id	SWS_FT_FI3
Number of Residues	26
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269\|PubMed:18390544, ECO:0000269\|PubMed:30598554

Chain	Residue	Details
H	TYR81-VAL94
Q	TYR81-VAL94
C	SER247-ASP287
C	ALA341-PRO347
L	MET52-ASN74
L	TYR136-SER172
L	SER247-ASP287
L	ALA341-PRO347

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:10873857, ECO:0000269\|PubMed:11880631, ECO:0000269\|PubMed:18390544, ECO:0000269\|PubMed:30598554, ECO:0007744\|PDB:1EZV, ECO:0007744\|PDB:1KB9, ECO:0007744\|PDB:1KYO, ECO:0007744\|PDB:1P84, ECO:0007744\|PDB:2IBZ, ECO:0007744\|PDB:3CX5, ECO:0007744\|PDB:3CXH, ECO:0007744\|PDB:4PD4

Chain	Residue	Details
E	CYS159
E	HIS161
E	CYS178
E	HIS181
N	CYS159
N	HIS161
N	CYS178
N	HIS181

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:11880631, ECO:0000269\|PubMed:18390544, ECO:0000269\|PubMed:30598554, ECO:0007744\|PDB:1KYO

Chain	Residue	Details
D	HIS105
M	HIS105
C	HIS183
C	HIS197
L	HIS82
L	HIS96
L	HIS183
L	HIS197

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:10873857, ECO:0000269\|PubMed:11880631, ECO:0000269\|PubMed:18390544, ECO:0000269\|PubMed:30598554, ECO:0007744\|PDB:1EZV, ECO:0007744\|PDB:1KYO

Chain	Residue	Details
D	MET225
M	MET225

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 208

Chain	Residue	Details
E	HIS181	covalently attached, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
B	LYS222	electrostatic stabiliser, hydrogen bond donor, radical stabiliser
B	PRO244	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
B	VAL245	electrostatic stabiliser, hydrogen bond acceptor, radical stabiliser
B	PHE288	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser

site_id	MCSA2
Number of Residues	1
Details	M-CSA 208

Chain	Residue	Details
N	HIS181	covalently attached, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)