Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8YH0

A3R-Gi complex bound to NECA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0001664	molecular_function	G protein-coupled receptor binding
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005765	cellular_component	lysosomal membrane
A	0005794	cellular_component	Golgi apparatus
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005834	cellular_component	heterotrimeric G-protein complex
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0005938	cellular_component	cell cortex
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
A	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
A	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
A	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A	0007198	biological_process	adenylate cyclase-inhibiting serotonin receptor signaling pathway
A	0007218	biological_process	neuropeptide signaling pathway
A	0010854	molecular_function	adenylate cyclase regulator activity
A	0010855	molecular_function	adenylate cyclase inhibitor activity
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0019001	molecular_function	guanyl nucleotide binding
A	0019003	molecular_function	GDP binding
A	0030496	cellular_component	midbody
A	0031681	molecular_function	G-protein beta-subunit binding
A	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
A	0031749	molecular_function	D2 dopamine receptor binding
A	0031821	molecular_function	G protein-coupled serotonin receptor binding
A	0034451	cellular_component	centriolar satellite
A	0034695	biological_process	response to prostaglandin E
A	0036064	cellular_component	ciliary basal body
A	0043434	biological_process	response to peptide hormone
A	0045202	cellular_component	synapse
A	0045542	biological_process	positive regulation of cholesterol biosynthetic process
A	0046676	biological_process	negative regulation of insulin secretion
A	0046872	molecular_function	metal ion binding
A	0048144	biological_process	fibroblast proliferation
A	0051301	biological_process	cell division
A	0060236	biological_process	regulation of mitotic spindle organization
A	0070062	cellular_component	extracellular exosome
A	0070098	biological_process	chemokine-mediated signaling pathway
A	0071380	biological_process	cellular response to prostaglandin E stimulus
A	0071870	biological_process	cellular response to catecholamine stimulus
A	0072678	biological_process	T cell migration
A	1901082	biological_process	positive regulation of relaxation of smooth muscle
A	1904322	biological_process	cellular response to forskolin
A	1904778	biological_process	positive regulation of protein localization to cell cortex
B	0001750	cellular_component	photoreceptor outer segment
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005834	cellular_component	heterotrimeric G-protein complex
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
B	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
B	0008283	biological_process	cell population proliferation
B	0016020	cellular_component	membrane
B	0030159	molecular_function	signaling receptor complex adaptor activity
B	0044877	molecular_function	protein-containing complex binding
B	0045202	cellular_component	synapse
B	0050909	biological_process	sensory perception of taste
B	0051020	molecular_function	GTPase binding
B	0060041	biological_process	retina development in camera-type eye
B	0071380	biological_process	cellular response to prostaglandin E stimulus
B	0071870	biological_process	cellular response to catecholamine stimulus
B	0097381	cellular_component	photoreceptor disc membrane
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0001664	molecular_function	G protein-coupled receptor binding
G	0003924	molecular_function	GTPase activity
G	0003925	molecular_function	G protein activity
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0005765	cellular_component	lysosomal membrane
G	0005794	cellular_component	Golgi apparatus
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0005834	cellular_component	heterotrimeric G-protein complex
G	0005856	cellular_component	cytoskeleton
G	0005886	cellular_component	plasma membrane
G	0005938	cellular_component	cell cortex
G	0007165	biological_process	signal transduction
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
G	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
G	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
G	0007198	biological_process	adenylate cyclase-inhibiting serotonin receptor signaling pathway
G	0007218	biological_process	neuropeptide signaling pathway
G	0010854	molecular_function	adenylate cyclase regulator activity
G	0010855	molecular_function	adenylate cyclase inhibitor activity
G	0016020	cellular_component	membrane
G	0016787	molecular_function	hydrolase activity
G	0019001	molecular_function	guanyl nucleotide binding
G	0019003	molecular_function	GDP binding
G	0030496	cellular_component	midbody
G	0031681	molecular_function	G-protein beta-subunit binding
G	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
G	0031749	molecular_function	D2 dopamine receptor binding
G	0031821	molecular_function	G protein-coupled serotonin receptor binding
G	0034451	cellular_component	centriolar satellite
G	0034695	biological_process	response to prostaglandin E
G	0036064	cellular_component	ciliary basal body
G	0043434	biological_process	response to peptide hormone
G	0045202	cellular_component	synapse
G	0045542	biological_process	positive regulation of cholesterol biosynthetic process
G	0046676	biological_process	negative regulation of insulin secretion
G	0046872	molecular_function	metal ion binding
G	0048144	biological_process	fibroblast proliferation
G	0051301	biological_process	cell division
G	0060236	biological_process	regulation of mitotic spindle organization
G	0070062	cellular_component	extracellular exosome
G	0070098	biological_process	chemokine-mediated signaling pathway
G	0071380	biological_process	cellular response to prostaglandin E stimulus
G	0071870	biological_process	cellular response to catecholamine stimulus
G	0072678	biological_process	T cell migration
G	1901082	biological_process	positive regulation of relaxation of smooth muscle
G	1904322	biological_process	cellular response to forskolin
G	1904778	biological_process	positive regulation of protein localization to cell cortex
R	0001609	molecular_function	G protein-coupled adenosine receptor activity
R	0001973	biological_process	G protein-coupled adenosine receptor signaling pathway
R	0004930	molecular_function	G protein-coupled receptor activity
R	0005886	cellular_component	plasma membrane
R	0006091	biological_process	generation of precursor metabolites and energy
R	0007165	biological_process	signal transduction
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0008218	biological_process	bioluminescence
R	0016020	cellular_component	membrane
R	0030425	cellular_component	dendrite
R	0045202	cellular_component	synapse

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASImSLLAIAVDRYLrV

Chain	Residue	Details
R	ALA96-VAL112

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS

Chain	Residue	Details
B	LEU70-SER84
B	ILE157-ILE171
B	LEU285-ALA299
B	VAL327-GLY341

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P62873

Chain	Residue	Details
B	SER2
G	ALA2

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphohistidine => ECO:0000269\|PubMed:12486123

Chain	Residue	Details
B	HIS266
G	CYS68

site_id	SWS_FT_FI3
Number of Residues	2
Details	LIPID: S-geranylgeranyl cysteine => ECO:0000250\|UniProtKB:P63212

Chain	Residue	Details
A	CYS-11
G	CYS68

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:21115486, ECO:0007744\|PDB:1KJY, ECO:0007744\|PDB:1Y3A, ECO:0007744\|PDB:2G83, ECO:0007744\|PDB:2GTP, ECO:0007744\|PDB:2IK8, ECO:0007744\|PDB:2OM2, ECO:0007744\|PDB:2XNS, ECO:0007744\|PDB:3ONW, ECO:0007744\|PDB:3QE0, ECO:0007744\|PDB:3QI2, ECO:0007744\|PDB:3UMR, ECO:0007744\|PDB:3UMS, ECO:0007744\|PDB:4G5Q

Chain	Residue	Details
A	GLU43
A	ASN269
G	GLU122
G	ASN348

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:18434541, ECO:0000269\|PubMed:22383884, ECO:0007744\|PDB:3QE0

Chain	Residue	Details
A	SER47
A	THR181
G	SER126
G	THR260

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744\|PDB:1KJY, ECO:0007744\|PDB:2OM2, ECO:0007744\|PDB:2XNS, ECO:0007744\|PDB:3ONW, ECO:0007744\|PDB:3QE0, ECO:0007744\|PDB:3QI2, ECO:0007744\|PDB:4G5Q

Chain	Residue	Details
A	SER151
G	SER230

site_id	SWS_FT_FI7
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744\|PDB:1KJY, ECO:0007744\|PDB:1Y3A, ECO:0007744\|PDB:2G83, ECO:0007744\|PDB:2GTP, ECO:0007744\|PDB:2IK8, ECO:0007744\|PDB:2OM2, ECO:0007744\|PDB:2XNS, ECO:0007744\|PDB:3ONW, ECO:0007744\|PDB:3QE0, ECO:0007744\|PDB:3QI2, ECO:0007744\|PDB:3UMR, ECO:0007744\|PDB:3UMS, ECO:0007744\|PDB:4G5Q

Chain	Residue	Details
A	LEU175
G	LEU254

site_id	SWS_FT_FI8
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:21115486

Chain	Residue	Details
A	ASP200
G	ASP279

site_id	SWS_FT_FI9
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744\|PDB:1Y3A, ECO:0007744\|PDB:2G83, ECO:0007744\|PDB:2GTP, ECO:0007744\|PDB:2IK8, ECO:0007744\|PDB:2OM2, ECO:0007744\|PDB:3ONW, ECO:0007744\|PDB:3QE0, ECO:0007744\|PDB:3QI2, ECO:0007744\|PDB:3UMR, ECO:0007744\|PDB:3UMS, ECO:0007744\|PDB:4G5Q

Chain	Residue	Details
A	ALA326
G	ALA405

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250

Chain	Residue	Details
A	ARG178
G	ARG257

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269\|PubMed:24141704

Chain	Residue	Details
A	GLN204
G	GLN283

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: ADP-ribosylcysteine; by pertussis toxin => ECO:0000250

Chain	Residue	Details
A	CYS351
G	CYS430

site_id	SWS_FT_FI13
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000250\|UniProtKB:P10824

Chain	Residue	Details
A	CYS3
G	CYS82

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)