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8YFG

Human PIEZO1-R2456H_MDFIC

Functional Information from GO Data
ChainGOidnamespacecontents
A0005261molecular_functionmonoatomic cation channel activity
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006812biological_processmonoatomic cation transport
A0008381molecular_functionmechanosensitive monoatomic ion channel activity
A0010831biological_processpositive regulation of myotube differentiation
A0016020cellular_componentmembrane
A0031258cellular_componentlamellipodium membrane
A0032420cellular_componentstereocilium
A0032437cellular_componentcuticular plate
A0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
A0033625biological_processpositive regulation of integrin activation
A0033634biological_processpositive regulation of cell-cell adhesion mediated by integrin
A0034220biological_processmonoatomic ion transmembrane transport
A0042391biological_processregulation of membrane potential
A0042995cellular_componentcell projection
A0050982biological_processdetection of mechanical stimulus
A0071260biological_processcellular response to mechanical stimulus
A0098655biological_processmonoatomic cation transmembrane transport
A0140135molecular_functionmechanosensitive monoatomic cation channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005515molecular_functionprotein binding
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006812biological_processmonoatomic cation transport
B0008381molecular_functionmechanosensitive monoatomic ion channel activity
B0010831biological_processpositive regulation of myotube differentiation
B0016020cellular_componentmembrane
B0031258cellular_componentlamellipodium membrane
B0032420cellular_componentstereocilium
B0032437cellular_componentcuticular plate
B0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
B0033625biological_processpositive regulation of integrin activation
B0033634biological_processpositive regulation of cell-cell adhesion mediated by integrin
B0034220biological_processmonoatomic ion transmembrane transport
B0042391biological_processregulation of membrane potential
B0042995cellular_componentcell projection
B0050982biological_processdetection of mechanical stimulus
B0071260biological_processcellular response to mechanical stimulus
B0098655biological_processmonoatomic cation transmembrane transport
B0140135molecular_functionmechanosensitive monoatomic cation channel activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0010468biological_processregulation of gene expression
C0016020cellular_componentmembrane
C0030111biological_processregulation of Wnt signaling pathway
C0030332molecular_functioncyclin binding
C0030957molecular_functionTat protein binding
C0042308biological_processnegative regulation of protein import into nucleus
C0045892biological_processnegative regulation of DNA-templated transcription
C0045893biological_processpositive regulation of DNA-templated transcription
C0046328biological_processregulation of JNK cascade
C0050434biological_processpositive regulation of viral transcription
C0140297molecular_functionDNA-binding transcription factor binding
D0005261molecular_functionmonoatomic cation channel activity
D0005515molecular_functionprotein binding
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006812biological_processmonoatomic cation transport
D0008381molecular_functionmechanosensitive monoatomic ion channel activity
D0010831biological_processpositive regulation of myotube differentiation
D0016020cellular_componentmembrane
D0031258cellular_componentlamellipodium membrane
D0032420cellular_componentstereocilium
D0032437cellular_componentcuticular plate
D0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
D0033625biological_processpositive regulation of integrin activation
D0033634biological_processpositive regulation of cell-cell adhesion mediated by integrin
D0034220biological_processmonoatomic ion transmembrane transport
D0042391biological_processregulation of membrane potential
D0042995cellular_componentcell projection
D0050982biological_processdetection of mechanical stimulus
D0071260biological_processcellular response to mechanical stimulus
D0098655biological_processmonoatomic cation transmembrane transport
D0140135molecular_functionmechanosensitive monoatomic cation channel activity
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005634cellular_componentnucleus
E0005730cellular_componentnucleolus
E0005737cellular_componentcytoplasm
E0005886cellular_componentplasma membrane
E0010468biological_processregulation of gene expression
E0016020cellular_componentmembrane
E0030111biological_processregulation of Wnt signaling pathway
E0030332molecular_functioncyclin binding
E0030957molecular_functionTat protein binding
E0042308biological_processnegative regulation of protein import into nucleus
E0045892biological_processnegative regulation of DNA-templated transcription
E0045893biological_processpositive regulation of DNA-templated transcription
E0046328biological_processregulation of JNK cascade
E0050434biological_processpositive regulation of viral transcription
E0140297molecular_functionDNA-binding transcription factor binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0005886cellular_componentplasma membrane
F0010468biological_processregulation of gene expression
F0016020cellular_componentmembrane
F0030111biological_processregulation of Wnt signaling pathway
F0030332molecular_functioncyclin binding
F0030957molecular_functionTat protein binding
F0042308biological_processnegative regulation of protein import into nucleus
F0045892biological_processnegative regulation of DNA-templated transcription
F0045893biological_processpositive regulation of DNA-templated transcription
F0046328biological_processregulation of JNK cascade
F0050434biological_processpositive regulation of viral transcription
F0140297molecular_functionDNA-binding transcription factor binding
Functional Information from PROSITE/UniProt
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CcCcgDemGDdC
ChainResidueDetails
CCYS202-CYS213

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YQCVAAH
ChainResidueDetails
ATYR1680-HIS1686

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues507
DetailsTOPO_DOM: Extracellular => ECO:0000250|UniProtKB:Q8BX65
ChainResidueDetails
CMET2-CYS171
AHIS460-LEU480
DILE1734-TRP1754
DALA1962-PHE1982
DALA2003-LEU2023
DALA2032-VAL2052
DVAL2061-ILE2081
DHIS2100-MET2122
DTHR2129-ILE2149
DGLY2177-VAL2197
DLEU2432-GLY2452
ALEU514-VAL534
ATYR579-VAL599
AILE602-TRP622
APHE629-PHE649
APHE681-PHE701
AVAL801-PHE821
APRO830-TYR850
ALEU926-TYR946
AILE987-ILE1007
EMET2-CYS171
ALEU1043-LEU1063
AVAL1160-THR1180
AILE1184-LEU1204
ALEU1218-VAL1240
APHE1247-TYR1264
ALEU1277-LEU1297
AALA1678-ASN1698
AMET1700-LEU1720
AILE1734-TRP1754
AALA1962-PHE1982
FMET2-CYS171
AALA2003-LEU2023
AALA2032-VAL2052
AVAL2061-ILE2081
AHIS2100-MET2122
ATHR2129-ILE2149
AGLY2177-VAL2197
ALEU2432-GLY2452
BVAL5-LEU25
BPHE27-PRO47
BLEU64-VAL84
AALA118-ILE138
BALA118-ILE138
BTRP194-ALA214
BALA218-PHE238
BLEU248-MET268
BLEU302-LEU322
BLEU428-LEU448
BHIS460-LEU480
BLEU514-VAL534
BTYR579-VAL599
BILE602-TRP622
ATRP194-ALA214
BPHE629-PHE649
BPHE681-PHE701
BVAL801-PHE821
BPRO830-TYR850
BLEU926-TYR946
BILE987-ILE1007
BLEU1043-LEU1063
BVAL1160-THR1180
BILE1184-LEU1204
BLEU1218-VAL1240
AALA218-PHE238
BPHE1247-TYR1264
BLEU1277-LEU1297
BALA1678-ASN1698
BMET1700-LEU1720
BILE1734-TRP1754
BALA1962-PHE1982
BALA2003-LEU2023
BALA2032-VAL2052
BVAL2061-ILE2081
BHIS2100-MET2122
ALEU248-MET268
BTHR2129-ILE2149
BGLY2177-VAL2197
BLEU2432-GLY2452
DVAL5-LEU25
DPHE27-PRO47
DLEU64-VAL84
DALA118-ILE138
DTRP194-ALA214
DALA218-PHE238
DLEU248-MET268
ALEU302-LEU322
DLEU302-LEU322
DLEU428-LEU448
DHIS460-LEU480
DLEU514-VAL534
DTYR579-VAL599
DILE602-TRP622
DPHE629-PHE649
DPHE681-PHE701
DVAL801-PHE821
DPRO830-TYR850
ALEU428-LEU448
DLEU926-TYR946
DILE987-ILE1007
DLEU1043-LEU1063
DVAL1160-THR1180
DILE1184-LEU1204
DLEU1218-VAL1240
DPHE1247-TYR1264
DLEU1277-LEU1297
DALA1678-ASN1698
DMET1700-LEU1720

site_idSWS_FT_FI2
Number of Residues51
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
CILE172-GLY189
EILE172-GLY189
FILE172-GLY189

site_idSWS_FT_FI3
Number of Residues171
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:Q8BX65
ChainResidueDetails
CGLN190-SER247
EGLN190-SER247
FGLN190-SER247

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER129
CSER144
ESER129
ESER144
FSER129
FSER144
DSER713
DSER1396
DSER1636

site_idSWS_FT_FI5
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER141
ESER141
FSER141

site_idSWS_FT_FI6
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER1646
BSER1646
DSER1646

site_idSWS_FT_FI7
Number of Residues3
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR1854
BTHR1854
DTHR1854

site_idSWS_FT_FI8
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN295
BASN295
DASN295

site_idSWS_FT_FI9
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973
ChainResidueDetails
AASN2294
BASN2294
DASN2294

234785

PDB entries from 2025-04-16

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