8YFG

Human PIEZO1-R2456H_MDFIC

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CcCcgDemGDdC

Chain	Residue	Details
C	CYS202-CYS213

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YQCVAAH

Chain	Residue	Details
A	TYR1680-HIS1686

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	507
Details	TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:Q8BX65

Chain	Residue	Details
C	MET2-CYS171
A	HIS460-LEU480
D	ILE1734-TRP1754
D	ALA1962-PHE1982
D	ALA2003-LEU2023
D	ALA2032-VAL2052
D	VAL2061-ILE2081
D	HIS2100-MET2122
D	THR2129-ILE2149
D	GLY2177-VAL2197
D	LEU2432-GLY2452
A	LEU514-VAL534
A	TYR579-VAL599
A	ILE602-TRP622
A	PHE629-PHE649
A	PHE681-PHE701
A	VAL801-PHE821
A	PRO830-TYR850
A	LEU926-TYR946
A	ILE987-ILE1007
E	MET2-CYS171
A	LEU1043-LEU1063
A	VAL1160-THR1180
A	ILE1184-LEU1204
A	LEU1218-VAL1240
A	PHE1247-TYR1264
A	LEU1277-LEU1297
A	ALA1678-ASN1698
A	MET1700-LEU1720
A	ILE1734-TRP1754
A	ALA1962-PHE1982
F	MET2-CYS171
A	ALA2003-LEU2023
A	ALA2032-VAL2052
A	VAL2061-ILE2081
A	HIS2100-MET2122
A	THR2129-ILE2149
A	GLY2177-VAL2197
A	LEU2432-GLY2452
B	VAL5-LEU25
B	PHE27-PRO47
B	LEU64-VAL84
A	ALA118-ILE138
B	ALA118-ILE138
B	TRP194-ALA214
B	ALA218-PHE238
B	LEU248-MET268
B	LEU302-LEU322
B	LEU428-LEU448
B	HIS460-LEU480
B	LEU514-VAL534
B	TYR579-VAL599
B	ILE602-TRP622
A	TRP194-ALA214
B	PHE629-PHE649
B	PHE681-PHE701
B	VAL801-PHE821
B	PRO830-TYR850
B	LEU926-TYR946
B	ILE987-ILE1007
B	LEU1043-LEU1063
B	VAL1160-THR1180
B	ILE1184-LEU1204
B	LEU1218-VAL1240
A	ALA218-PHE238
B	PHE1247-TYR1264
B	LEU1277-LEU1297
B	ALA1678-ASN1698
B	MET1700-LEU1720
B	ILE1734-TRP1754
B	ALA1962-PHE1982
B	ALA2003-LEU2023
B	ALA2032-VAL2052
B	VAL2061-ILE2081
B	HIS2100-MET2122
A	LEU248-MET268
B	THR2129-ILE2149
B	GLY2177-VAL2197
B	LEU2432-GLY2452
D	VAL5-LEU25
D	PHE27-PRO47
D	LEU64-VAL84
D	ALA118-ILE138
D	TRP194-ALA214
D	ALA218-PHE238
D	LEU248-MET268
A	LEU302-LEU322
D	LEU302-LEU322
D	LEU428-LEU448
D	HIS460-LEU480
D	LEU514-VAL534
D	TYR579-VAL599
D	ILE602-TRP622
D	PHE629-PHE649
D	PHE681-PHE701
D	VAL801-PHE821
D	PRO830-TYR850
A	LEU428-LEU448
D	LEU926-TYR946
D	ILE987-ILE1007
D	LEU1043-LEU1063
D	VAL1160-THR1180
D	ILE1184-LEU1204
D	LEU1218-VAL1240
D	PHE1247-TYR1264
D	LEU1277-LEU1297
D	ALA1678-ASN1698
D	MET1700-LEU1720

---

site_id	SWS_FT_FI2
Number of Residues	51
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
C	ILE172-GLY189
E	ILE172-GLY189
F	ILE172-GLY189

---

site_id	SWS_FT_FI3
Number of Residues	171
Details	TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:Q8BX65

Chain	Residue	Details
C	GLN190-SER247
E	GLN190-SER247
F	GLN190-SER247

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER129
C	SER144
E	SER129
E	SER144
F	SER129
F	SER144
D	SER713
D	SER1396
D	SER1636

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER141
E	SER141
F	SER141

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER1646
B	SER1646
D	SER1646

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR1854
B	THR1854
D	THR1854

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN295
B	ASN295
D	ASN295

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973

Chain	Residue	Details
A	ASN2294
B	ASN2294
D	ASN2294

---