8YF0
Cryo-EM structure of human SV2A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005911 | cellular_component | cell-cell junction |
| B | 0006836 | biological_process | neurotransmitter transport |
| B | 0006874 | biological_process | intracellular calcium ion homeostasis |
| B | 0008021 | cellular_component | synaptic vesicle |
| B | 0014052 | biological_process | regulation of gamma-aminobutyric acid secretion |
| B | 0016020 | cellular_component | membrane |
| B | 0016082 | biological_process | synaptic vesicle priming |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0030425 | cellular_component | dendrite |
| B | 0030672 | cellular_component | synaptic vesicle membrane |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0031594 | cellular_component | neuromuscular junction |
| B | 0042995 | cellular_component | cell projection |
| B | 0043005 | cellular_component | neuron projection |
| B | 0043025 | cellular_component | neuronal cell body |
| B | 0045202 | cellular_component | synapse |
| B | 0048786 | cellular_component | presynaptic active zone |
| B | 0098793 | cellular_component | presynapse |
| B | 0098978 | cellular_component | glutamatergic synapse |
| B | 0098982 | cellular_component | GABA-ergic synapse |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0005911 | cellular_component | cell-cell junction |
| C | 0006836 | biological_process | neurotransmitter transport |
| C | 0006874 | biological_process | intracellular calcium ion homeostasis |
| C | 0008021 | cellular_component | synaptic vesicle |
| C | 0014052 | biological_process | regulation of gamma-aminobutyric acid secretion |
| C | 0016020 | cellular_component | membrane |
| C | 0016082 | biological_process | synaptic vesicle priming |
| C | 0019901 | molecular_function | protein kinase binding |
| C | 0030425 | cellular_component | dendrite |
| C | 0030672 | cellular_component | synaptic vesicle membrane |
| C | 0031410 | cellular_component | cytoplasmic vesicle |
| C | 0031594 | cellular_component | neuromuscular junction |
| C | 0042995 | cellular_component | cell projection |
| C | 0043005 | cellular_component | neuron projection |
| C | 0043025 | cellular_component | neuronal cell body |
| C | 0045202 | cellular_component | synapse |
| C | 0048786 | cellular_component | presynaptic active zone |
| C | 0098793 | cellular_component | presynapse |
| C | 0098978 | cellular_component | glutamatergic synapse |
| C | 0098982 | cellular_component | GABA-ergic synapse |
Functional Information from PROSITE/UniProt
| site_id | PS00217 |
| Number of Residues | 26 |
| Details | SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. LsGVGiGGsipivfsYfsEflaqekR |
| Chain | Residue | Details |
| B | LEU264-ARG289 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 586 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| B | MET1-TYR169 | |
| C | GLU356-THR447 | |
| C | ASP620-ARG626 | |
| C | THR673-ALA685 | |
| B | ASP227-GLN233 | |
| B | LEU284-SER294 | |
| B | GLU356-THR447 | |
| B | ASP620-ARG626 | |
| B | THR673-ALA685 | |
| C | MET1-TYR169 | |
| C | ASP227-GLN233 | |
| C | LEU284-SER294 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 480 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| B | PHE170-LEU190 | |
| B | ILE652-LEU672 | |
| B | PHE686-VAL708 | |
| B | ALA713-LEU731 | |
| C | PHE170-LEU190 | |
| C | MET206-ALA226 | |
| C | CYS234-GLY254 | |
| C | LEU263-PHE283 | |
| C | TRP295-ILE315 | |
| C | VAL335-PRO355 | |
| C | LEU448-PHE468 | |
| B | MET206-ALA226 | |
| C | PHE599-MET619 | |
| C | MET627-SER647 | |
| C | ILE652-LEU672 | |
| C | PHE686-VAL708 | |
| C | ALA713-LEU731 | |
| B | CYS234-GLY254 | |
| B | LEU263-PHE283 | |
| B | TRP295-ILE315 | |
| B | VAL335-PRO355 | |
| B | LEU448-PHE468 | |
| B | PHE599-MET619 | |
| B | MET627-SER647 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 348 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| B | PRO191-GLY205 | |
| C | PRO469-TYR598 | |
| C | GLU648-MET651 | |
| C | GLY709-LYS712 | |
| B | TYR255-ARG262 | |
| B | PRO316-ARG334 | |
| B | PRO469-TYR598 | |
| B | GLU648-MET651 | |
| B | GLY709-LYS712 | |
| C | PRO191-GLY205 | |
| C | TYR255-ARG262 | |
| C | PRO316-ARG334 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| B | SER80 | |
| B | SER81 | |
| C | SER80 | |
| C | SER81 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| B | THR84 | |
| C | THR84 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9JIS5 |
| Chain | Residue | Details |
| B | SER127 | |
| C | SER127 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q02563 |
| Chain | Residue | Details |
| B | SER393 | |
| C | SER393 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9JIS5 |
| Chain | Residue | Details |
| B | TYR480 | |
| C | TYR480 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN498 | |
| B | ASN548 | |
| B | ASN573 | |
| C | ASN498 | |
| C | ASN548 | |
| C | ASN573 |
