Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8YCX

CryoEM structure of M. tuberculosis ClpC1P1P2 complex bound to bortezomib, conformation 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity
B	0005524	molecular_function	ATP binding
B	0016887	molecular_function	ATP hydrolysis activity
C	0005524	molecular_function	ATP binding
C	0016887	molecular_function	ATP hydrolysis activity
D	0005524	molecular_function	ATP binding
D	0016887	molecular_function	ATP hydrolysis activity
E	0005524	molecular_function	ATP binding
E	0016887	molecular_function	ATP hydrolysis activity
F	0005524	molecular_function	ATP binding
F	0016887	molecular_function	ATP hydrolysis activity
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0008233	molecular_function	peptidase activity
G	0008236	molecular_function	serine-type peptidase activity
G	0009274	cellular_component	peptidoglycan-based cell wall
G	0009368	cellular_component	endopeptidase Clp complex
G	0016787	molecular_function	hydrolase activity
G	0051117	molecular_function	ATPase binding
H	0004176	molecular_function	ATP-dependent peptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006508	biological_process	proteolysis
H	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
H	0008233	molecular_function	peptidase activity
H	0008236	molecular_function	serine-type peptidase activity
H	0009274	cellular_component	peptidoglycan-based cell wall
H	0009368	cellular_component	endopeptidase Clp complex
H	0016787	molecular_function	hydrolase activity
H	0051117	molecular_function	ATPase binding
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0008233	molecular_function	peptidase activity
I	0008236	molecular_function	serine-type peptidase activity
I	0009274	cellular_component	peptidoglycan-based cell wall
I	0009368	cellular_component	endopeptidase Clp complex
I	0016787	molecular_function	hydrolase activity
I	0051117	molecular_function	ATPase binding
J	0004176	molecular_function	ATP-dependent peptidase activity
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006508	biological_process	proteolysis
J	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
J	0008233	molecular_function	peptidase activity
J	0008236	molecular_function	serine-type peptidase activity
J	0009274	cellular_component	peptidoglycan-based cell wall
J	0009368	cellular_component	endopeptidase Clp complex
J	0016787	molecular_function	hydrolase activity
J	0051117	molecular_function	ATPase binding
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0008233	molecular_function	peptidase activity
K	0008236	molecular_function	serine-type peptidase activity
K	0009274	cellular_component	peptidoglycan-based cell wall
K	0009368	cellular_component	endopeptidase Clp complex
K	0016787	molecular_function	hydrolase activity
K	0051117	molecular_function	ATPase binding
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0008233	molecular_function	peptidase activity
L	0008236	molecular_function	serine-type peptidase activity
L	0009274	cellular_component	peptidoglycan-based cell wall
L	0009368	cellular_component	endopeptidase Clp complex
L	0016787	molecular_function	hydrolase activity
L	0051117	molecular_function	ATPase binding
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0008233	molecular_function	peptidase activity
M	0008236	molecular_function	serine-type peptidase activity
M	0009274	cellular_component	peptidoglycan-based cell wall
M	0009368	cellular_component	endopeptidase Clp complex
M	0016787	molecular_function	hydrolase activity
M	0051117	molecular_function	ATPase binding
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0006508	biological_process	proteolysis
O	0004176	molecular_function	ATP-dependent peptidase activity
O	0004252	molecular_function	serine-type endopeptidase activity
O	0006508	biological_process	proteolysis
P	0004176	molecular_function	ATP-dependent peptidase activity
P	0004252	molecular_function	serine-type endopeptidase activity
P	0006508	biological_process	proteolysis
Q	0004176	molecular_function	ATP-dependent peptidase activity
Q	0004252	molecular_function	serine-type endopeptidase activity
Q	0006508	biological_process	proteolysis
R	0004176	molecular_function	ATP-dependent peptidase activity
R	0004252	molecular_function	serine-type endopeptidase activity
R	0006508	biological_process	proteolysis
S	0004176	molecular_function	ATP-dependent peptidase activity
S	0004252	molecular_function	serine-type endopeptidase activity
S	0006508	biological_process	proteolysis
T	0004176	molecular_function	ATP-dependent peptidase activity
T	0004252	molecular_function	serine-type endopeptidase activity
T	0006508	biological_process	proteolysis

Functional Information from PROSITE/UniProt

site_id	PS00306
Number of Residues	8
Details	CASEIN_ALPHA_BETA Caseins alpha/beta signature. CLVAlALA

Chain	Residue	Details
U	CYS8-ALA15

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TvcLGqAASAAA

Chain	Residue	Details
G	THR102-ALA113

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RyalPharILMHQP

Chain	Residue	Details
N	ARG112-PRO125
G	ARG124-PRO137

site_id	PS00870
Number of Residues	13
Details	CLPAB_1 Chaperonins clpA/B signature 1. DAASILKPkLarG

Chain	Residue	Details
A	ASP303-GLY315

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	573
Details	Region: {"description":"II"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	77
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	14
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	14
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)