8Y9C
De novo design mini-binder in complex with TcdB4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0008289 | molecular_function | lipid binding |
| B | 0016020 | cellular_component | membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0020002 | cellular_component | host cell plasma membrane |
| B | 0030430 | cellular_component | host cell cytoplasm |
| B | 0033644 | cellular_component | host cell membrane |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0044164 | cellular_component | host cell cytosol |
| B | 0044174 | cellular_component | host cell endosome |
| B | 0044175 | cellular_component | host cell endosome membrane |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0090729 | molecular_function | toxin activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 373 |
| Details | Domain: {"description":"GT44","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 207 |
| Details | Domain: {"description":"Peptidase C80","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | Repeat: {"description":"Cell wall-binding 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00591","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 89 |
| Details | Region: {"description":"Four-helical bundle","evidences":[{"source":"UniProtKB","id":"Q46342","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 373 |
| Details | Region: {"description":"Glucosyltransferase region","evidences":[{"source":"UniProtKB","id":"P18177","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 255 |
| Details | Region: {"description":"Autoprocessing region","evidences":[{"source":"UniProtKB","id":"P18177","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 32 |
| Details | Region: {"description":"Interaction with host frizzled receptors FZD1, FZD2 and FZD7","evidences":[{"source":"UniProtKB","id":"P18177","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile; for protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P18177","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P16154","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage; by autolysis","evidences":[{"source":"PubMed","id":"15632438","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
