8Y8S
Cryo-EM structure of AQP3 in DMPC nanodisc
Functional Information from PROSITE/UniProt
| site_id | PS00221 |
| Number of Residues | 9 |
| Details | MIP MIP family signature. HLNPAVTFA |
| Chain | Residue | Details |
| A | HIS81-ALA89 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 284 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:O14520 |
| Chain | Residue | Details |
| A | MET1-GLN24 | |
| B | ILE265-ILE292 | |
| C | MET1-GLN24 | |
| C | GLY75-SER78 | |
| C | LEU93-LYS100 | |
| C | ILE178-GLY189 | |
| C | ILE265-ILE292 | |
| D | MET1-GLN24 | |
| D | GLY75-SER78 | |
| D | LEU93-LYS100 | |
| D | ILE178-GLY189 | |
| A | GLY75-SER78 | |
| D | ILE265-ILE292 | |
| A | LEU93-LYS100 | |
| A | ILE178-GLY189 | |
| A | ILE265-ILE292 | |
| B | MET1-GLN24 | |
| B | GLY75-SER78 | |
| B | LEU93-LYS100 | |
| B | ILE178-GLY189 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 68 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000250|UniProtKB:O14520 |
| Chain | Residue | Details |
| A | ALA25-SER42 | |
| B | ALA25-SER42 | |
| C | ALA25-SER42 | |
| D | ALA25-SER42 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 280 |
| Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:O14520 |
| Chain | Residue | Details |
| A | VAL43-PHE56 | |
| C | LEU122-ASN159 | |
| C | GLY207-SER210 | |
| C | PHE225-TRP242 | |
| D | VAL43-PHE56 | |
| D | LEU122-ASN159 | |
| D | GLY207-SER210 | |
| D | PHE225-TRP242 | |
| A | LEU122-ASN159 | |
| A | GLY207-SER210 | |
| A | PHE225-TRP242 | |
| B | VAL43-PHE56 | |
| B | LEU122-ASN159 | |
| B | GLY207-SER210 | |
| B | PHE225-TRP242 | |
| C | VAL43-PHE56 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 68 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000250|UniProtKB:O14520 |
| Chain | Residue | Details |
| A | LEU57-ALA74 | |
| B | LEU57-ALA74 | |
| C | LEU57-ALA74 | |
| D | LEU57-ALA74 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 104 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:O14520 |
| Chain | Residue | Details |
| A | GLY79-PHE92 | |
| A | GLY211-LEU224 | |
| B | GLY79-PHE92 | |
| B | GLY211-LEU224 | |
| C | GLY79-PHE92 | |
| C | GLY211-LEU224 | |
| D | GLY79-PHE92 | |
| D | GLY211-LEU224 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000250|UniProtKB:O14520 |
| Chain | Residue | Details |
| A | LEU101-GLY121 | |
| B | LEU101-GLY121 | |
| C | LEU101-GLY121 | |
| D | LEU101-GLY121 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 68 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000250|UniProtKB:O14520 |
| Chain | Residue | Details |
| A | GLY160-ALA177 | |
| B | GLY160-ALA177 | |
| C | GLY160-ALA177 | |
| D | GLY160-ALA177 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 64 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000250|UniProtKB:O14520 |
| Chain | Residue | Details |
| A | LEU190-MET206 | |
| B | LEU190-MET206 | |
| C | LEU190-MET206 | |
| D | LEU190-MET206 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 84 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000250|UniProtKB:O14520 |
| Chain | Residue | Details |
| A | TRP243-MET264 | |
| B | TRP243-MET264 | |
| C | TRP243-MET264 | |
| D | TRP243-MET264 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 12 |
| Details | SITE: Selectivity filter => ECO:0000250|UniProtKB:O14520 |
| Chain | Residue | Details |
| A | PHE63 | |
| D | PHE63 | |
| D | TYR212 | |
| D | ARG218 | |
| A | TYR212 | |
| A | ARG218 | |
| B | PHE63 | |
| B | TYR212 | |
| B | ARG218 | |
| C | PHE63 | |
| C | TYR212 | |
| C | ARG218 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN141 | |
| B | ASN141 | |
| C | ASN141 | |
| D | ASN141 |
