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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8Y8S

Cryo-EM structure of AQP3 in DMPC nanodisc

Functional Information from GO Data
ChainGOidnamespacecontents
A0002684biological_processpositive regulation of immune system process
A0002931biological_processresponse to ischemia
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0006833biological_processwater transport
A0015166molecular_functionpolyol transmembrane transporter activity
A0015204molecular_functionurea transmembrane transporter activity
A0015250molecular_functionwater channel activity
A0015254molecular_functionglycerol channel activity
A0015267molecular_functionchannel activity
A0015791biological_processpolyol transmembrane transport
A0015793biological_processglycerol transmembrane transport
A0015840biological_processurea transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0022857molecular_functiontransmembrane transporter activity
A0032526biological_processresponse to retinoic acid
A0042476biological_processodontogenesis
A0042802molecular_functionidentical protein binding
A0055085biological_processtransmembrane transport
A0070295biological_processrenal water absorption
A0071456biological_processcellular response to hypoxia
A0071918biological_processurea transmembrane transport
B0002684biological_processpositive regulation of immune system process
B0002931biological_processresponse to ischemia
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0006833biological_processwater transport
B0015166molecular_functionpolyol transmembrane transporter activity
B0015204molecular_functionurea transmembrane transporter activity
B0015250molecular_functionwater channel activity
B0015254molecular_functionglycerol channel activity
B0015267molecular_functionchannel activity
B0015791biological_processpolyol transmembrane transport
B0015793biological_processglycerol transmembrane transport
B0015840biological_processurea transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0022857molecular_functiontransmembrane transporter activity
B0032526biological_processresponse to retinoic acid
B0042476biological_processodontogenesis
B0042802molecular_functionidentical protein binding
B0055085biological_processtransmembrane transport
B0070295biological_processrenal water absorption
B0071456biological_processcellular response to hypoxia
B0071918biological_processurea transmembrane transport
C0002684biological_processpositive regulation of immune system process
C0002931biological_processresponse to ischemia
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0005911cellular_componentcell-cell junction
C0006833biological_processwater transport
C0015166molecular_functionpolyol transmembrane transporter activity
C0015204molecular_functionurea transmembrane transporter activity
C0015250molecular_functionwater channel activity
C0015254molecular_functionglycerol channel activity
C0015267molecular_functionchannel activity
C0015791biological_processpolyol transmembrane transport
C0015793biological_processglycerol transmembrane transport
C0015840biological_processurea transport
C0016020cellular_componentmembrane
C0016323cellular_componentbasolateral plasma membrane
C0022857molecular_functiontransmembrane transporter activity
C0032526biological_processresponse to retinoic acid
C0042476biological_processodontogenesis
C0042802molecular_functionidentical protein binding
C0055085biological_processtransmembrane transport
C0070295biological_processrenal water absorption
C0071456biological_processcellular response to hypoxia
C0071918biological_processurea transmembrane transport
D0002684biological_processpositive regulation of immune system process
D0002931biological_processresponse to ischemia
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0005911cellular_componentcell-cell junction
D0006833biological_processwater transport
D0015166molecular_functionpolyol transmembrane transporter activity
D0015204molecular_functionurea transmembrane transporter activity
D0015250molecular_functionwater channel activity
D0015254molecular_functionglycerol channel activity
D0015267molecular_functionchannel activity
D0015791biological_processpolyol transmembrane transport
D0015793biological_processglycerol transmembrane transport
D0015840biological_processurea transport
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0022857molecular_functiontransmembrane transporter activity
D0032526biological_processresponse to retinoic acid
D0042476biological_processodontogenesis
D0042802molecular_functionidentical protein binding
D0055085biological_processtransmembrane transport
D0070295biological_processrenal water absorption
D0071456biological_processcellular response to hypoxia
D0071918biological_processurea transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00221
Number of Residues9
DetailsMIP MIP family signature. HLNPAVTFA
ChainResidueDetails
AHIS81-ALA89
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues68
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues280
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues68
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues84
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues104
DetailsIntramembrane: {"description":"Discontinuously helical","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues68
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues64
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues8
DetailsMotif: {"description":"NPA 1","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues8
DetailsMotif: {"description":"NPA 2","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues12
DetailsSite: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

249697

PDB entries from 2026-02-25

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