8Y8P
Cryo-EM structure of AQP3 Y212F in POPC nanodisc
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002684 | biological_process | positive regulation of immune system process |
| A | 0002931 | biological_process | response to ischemia |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005911 | cellular_component | cell-cell junction |
| A | 0006833 | biological_process | water transport |
| A | 0015166 | molecular_function | polyol transmembrane transporter activity |
| A | 0015204 | molecular_function | urea transmembrane transporter activity |
| A | 0015250 | molecular_function | water channel activity |
| A | 0015254 | molecular_function | glycerol channel activity |
| A | 0015267 | molecular_function | channel activity |
| A | 0015791 | biological_process | polyol transmembrane transport |
| A | 0015793 | biological_process | glycerol transmembrane transport |
| A | 0015840 | biological_process | urea transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0032526 | biological_process | response to retinoic acid |
| A | 0042476 | biological_process | odontogenesis |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070295 | biological_process | renal water absorption |
| A | 0071456 | biological_process | cellular response to hypoxia |
| A | 0071918 | biological_process | urea transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00221 |
| Number of Residues | 9 |
| Details | MIP MIP family signature. HLNPAVTFA |
| Chain | Residue | Details |
| A | HIS81-ALA89 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 70 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 26 |
| Details | Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Motif: {"description":"NPA 1","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Motif: {"description":"NPA 2","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | Site: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"O14520","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
