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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8Y89

Structure of HCoV-HKU1C spike in the functionally anchored-3up conformation with 2TMPRSS2

Functional Information from GO Data
ChainGOidnamespacecontents
A0016020cellular_componentmembrane
A0019031cellular_componentviral envelope
A0019062biological_processvirion attachment to host cell
A0019064biological_processfusion of virus membrane with host plasma membrane
A0020002cellular_componenthost cell plasma membrane
A0039654biological_processfusion of virus membrane with host endosome membrane
A0039663biological_processmembrane fusion involved in viral entry into host cell
A0042802molecular_functionidentical protein binding
A0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
A0044423cellular_componentvirion component
A0046718biological_processsymbiont entry into host cell
A0046813biological_processreceptor-mediated virion attachment to host cell
A0055036cellular_componentvirion membrane
A0075509biological_processendocytosis involved in viral entry into host cell
B0016020cellular_componentmembrane
B0019031cellular_componentviral envelope
B0019062biological_processvirion attachment to host cell
B0019064biological_processfusion of virus membrane with host plasma membrane
B0020002cellular_componenthost cell plasma membrane
B0039654biological_processfusion of virus membrane with host endosome membrane
B0039663biological_processmembrane fusion involved in viral entry into host cell
B0042802molecular_functionidentical protein binding
B0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
B0044423cellular_componentvirion component
B0046718biological_processsymbiont entry into host cell
B0046813biological_processreceptor-mediated virion attachment to host cell
B0055036cellular_componentvirion membrane
B0075509biological_processendocytosis involved in viral entry into host cell
C0016020cellular_componentmembrane
C0019031cellular_componentviral envelope
C0019062biological_processvirion attachment to host cell
C0019064biological_processfusion of virus membrane with host plasma membrane
C0020002cellular_componenthost cell plasma membrane
C0039654biological_processfusion of virus membrane with host endosome membrane
C0039663biological_processmembrane fusion involved in viral entry into host cell
C0042802molecular_functionidentical protein binding
C0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
C0044423cellular_componentvirion component
C0046718biological_processsymbiont entry into host cell
C0046813biological_processreceptor-mediated virion attachment to host cell
C0055036cellular_componentvirion membrane
C0075509biological_processendocytosis involved in viral entry into host cell
G0004252molecular_functionserine-type endopeptidase activity
G0006508biological_processproteolysis
G0016020cellular_componentmembrane
T0004252molecular_functionserine-type endopeptidase activity
T0006508biological_processproteolysis
T0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC
ChainResidueDetails
TVAL292-CYS297
site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV
ChainResidueDetails
TASP435-VAL446
site_idPS01209
Number of Residues23
DetailsLDLRA_1 LDL-receptor class A (LDLRA) domain signature. CInpsnw.CDgvsHCpgg.EDEnr...C
ChainResidueDetails
TCYS127-CYS149
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues63
DetailsRegion: {"description":"Fusion peptide 1","evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues60
DetailsRegion: {"description":"Fusion peptide 2","evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues150
DetailsRegion: {"description":"Heptad repeat 1","evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues132
DetailsCoiled coil: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues3
DetailsSite: {"description":"Cleavage","evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues72
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues560
DetailsDomain: {"description":"BetaCoV S1-NTD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01270","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues472
DetailsDomain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XYD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HD8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues260
DetailsRegion: {"description":"HKU1-CoV S protein-binding","evidences":[{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964328","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsActive site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11245484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsActive site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

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PDB entries from 2026-01-14

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