8Y7O

FluPol-NS2 complex (hexamer)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0006351	biological_process	DNA-templated transcription
A	0016787	molecular_function	hydrolase activity
A	0030430	cellular_component	host cell cytoplasm
A	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
A	0039657	biological_process	symbiont-mediated suppression of host gene expression
A	0039694	biological_process	viral RNA genome replication
A	0042025	cellular_component	host cell nucleus
A	0046872	molecular_function	metal ion binding
A	0075523	biological_process	viral translational frameshifting
A	0075526	biological_process	cap snatching
B	0000166	molecular_function	nucleotide binding
B	0001172	biological_process	RNA-templated transcription
B	0003723	molecular_function	RNA binding
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0006351	biological_process	DNA-templated transcription
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0019083	biological_process	viral transcription
B	0030430	cellular_component	host cell cytoplasm
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
B	0039657	biological_process	symbiont-mediated suppression of host gene expression
B	0039694	biological_process	viral RNA genome replication
B	0042025	cellular_component	host cell nucleus
C	0001172	biological_process	RNA-templated transcription
C	0003723	molecular_function	RNA binding
C	0003968	molecular_function	RNA-directed RNA polymerase activity
C	0006351	biological_process	DNA-templated transcription
C	0006370	biological_process	7-methylguanosine mRNA capping
C	0006397	biological_process	mRNA processing
C	0019083	biological_process	viral transcription
C	0033650	cellular_component	host cell mitochondrion
C	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
C	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
C	0039657	biological_process	symbiont-mediated suppression of host gene expression
C	0039694	biological_process	viral RNA genome replication
C	0042025	cellular_component	host cell nucleus
C	0044423	cellular_component	virion component
C	0052031	biological_process	symbiont-mediated perturbation of host defense response
C	0052170	biological_process	symbiont-mediated suppression of host innate immune response
C	0075526	biological_process	cap snatching
D	0001172	biological_process	RNA-templated transcription
D	0003723	molecular_function	RNA binding
D	0003968	molecular_function	RNA-directed RNA polymerase activity
D	0006351	biological_process	DNA-templated transcription
D	0006370	biological_process	7-methylguanosine mRNA capping
D	0006397	biological_process	mRNA processing
D	0019083	biological_process	viral transcription
D	0033650	cellular_component	host cell mitochondrion
D	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
D	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
D	0039657	biological_process	symbiont-mediated suppression of host gene expression
D	0039694	biological_process	viral RNA genome replication
D	0042025	cellular_component	host cell nucleus
D	0044423	cellular_component	virion component
D	0052031	biological_process	symbiont-mediated perturbation of host defense response
D	0052170	biological_process	symbiont-mediated suppression of host innate immune response
D	0075526	biological_process	cap snatching
E	0003723	molecular_function	RNA binding
E	0004518	molecular_function	nuclease activity
E	0004519	molecular_function	endonuclease activity
E	0006351	biological_process	DNA-templated transcription
E	0016787	molecular_function	hydrolase activity
E	0030430	cellular_component	host cell cytoplasm
E	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
E	0039657	biological_process	symbiont-mediated suppression of host gene expression
E	0039694	biological_process	viral RNA genome replication
E	0042025	cellular_component	host cell nucleus
E	0046872	molecular_function	metal ion binding
E	0075523	biological_process	viral translational frameshifting
E	0075526	biological_process	cap snatching
F	0000166	molecular_function	nucleotide binding
F	0001172	biological_process	RNA-templated transcription
F	0003723	molecular_function	RNA binding
F	0003968	molecular_function	RNA-directed RNA polymerase activity
F	0006351	biological_process	DNA-templated transcription
F	0016740	molecular_function	transferase activity
F	0016779	molecular_function	nucleotidyltransferase activity
F	0019083	biological_process	viral transcription
F	0030430	cellular_component	host cell cytoplasm
F	0034062	molecular_function	5'-3' RNA polymerase activity
F	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
F	0039657	biological_process	symbiont-mediated suppression of host gene expression
F	0039694	biological_process	viral RNA genome replication
F	0042025	cellular_component	host cell nucleus
G	0001172	biological_process	RNA-templated transcription
G	0003723	molecular_function	RNA binding
G	0003968	molecular_function	RNA-directed RNA polymerase activity
G	0006351	biological_process	DNA-templated transcription
G	0006370	biological_process	7-methylguanosine mRNA capping
G	0006397	biological_process	mRNA processing
G	0019083	biological_process	viral transcription
G	0033650	cellular_component	host cell mitochondrion
G	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
G	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
G	0039657	biological_process	symbiont-mediated suppression of host gene expression
G	0039694	biological_process	viral RNA genome replication
G	0042025	cellular_component	host cell nucleus
G	0044423	cellular_component	virion component
G	0052031	biological_process	symbiont-mediated perturbation of host defense response
G	0052170	biological_process	symbiont-mediated suppression of host innate immune response
G	0075526	biological_process	cap snatching
H	0000166	molecular_function	nucleotide binding
H	0001172	biological_process	RNA-templated transcription
H	0003723	molecular_function	RNA binding
H	0003968	molecular_function	RNA-directed RNA polymerase activity
H	0006351	biological_process	DNA-templated transcription
H	0016740	molecular_function	transferase activity
H	0016779	molecular_function	nucleotidyltransferase activity
H	0019083	biological_process	viral transcription
H	0030430	cellular_component	host cell cytoplasm
H	0034062	molecular_function	5'-3' RNA polymerase activity
H	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
H	0039657	biological_process	symbiont-mediated suppression of host gene expression
H	0039694	biological_process	viral RNA genome replication
H	0042025	cellular_component	host cell nucleus
I	0003723	molecular_function	RNA binding
I	0004518	molecular_function	nuclease activity
I	0004519	molecular_function	endonuclease activity
I	0006351	biological_process	DNA-templated transcription
I	0016787	molecular_function	hydrolase activity
I	0030430	cellular_component	host cell cytoplasm
I	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
I	0039657	biological_process	symbiont-mediated suppression of host gene expression
I	0039694	biological_process	viral RNA genome replication
I	0042025	cellular_component	host cell nucleus
I	0046872	molecular_function	metal ion binding
I	0075523	biological_process	viral translational frameshifting
I	0075526	biological_process	cap snatching
J	0000166	molecular_function	nucleotide binding
J	0001172	biological_process	RNA-templated transcription
J	0003723	molecular_function	RNA binding
J	0003968	molecular_function	RNA-directed RNA polymerase activity
J	0006351	biological_process	DNA-templated transcription
J	0016740	molecular_function	transferase activity
J	0016779	molecular_function	nucleotidyltransferase activity
J	0019083	biological_process	viral transcription
J	0030430	cellular_component	host cell cytoplasm
J	0034062	molecular_function	5'-3' RNA polymerase activity
J	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
J	0039657	biological_process	symbiont-mediated suppression of host gene expression
J	0039694	biological_process	viral RNA genome replication
J	0042025	cellular_component	host cell nucleus
K	0001172	biological_process	RNA-templated transcription
K	0003723	molecular_function	RNA binding
K	0003968	molecular_function	RNA-directed RNA polymerase activity
K	0006351	biological_process	DNA-templated transcription
K	0006370	biological_process	7-methylguanosine mRNA capping
K	0006397	biological_process	mRNA processing
K	0019083	biological_process	viral transcription
K	0033650	cellular_component	host cell mitochondrion
K	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
K	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
K	0039657	biological_process	symbiont-mediated suppression of host gene expression
K	0039694	biological_process	viral RNA genome replication
K	0042025	cellular_component	host cell nucleus
K	0044423	cellular_component	virion component
K	0052031	biological_process	symbiont-mediated perturbation of host defense response
K	0052170	biological_process	symbiont-mediated suppression of host innate immune response
K	0075526	biological_process	cap snatching
L	0003723	molecular_function	RNA binding
L	0004518	molecular_function	nuclease activity
L	0004519	molecular_function	endonuclease activity
L	0006351	biological_process	DNA-templated transcription
L	0016787	molecular_function	hydrolase activity
L	0030430	cellular_component	host cell cytoplasm
L	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
L	0039657	biological_process	symbiont-mediated suppression of host gene expression
L	0039694	biological_process	viral RNA genome replication
L	0042025	cellular_component	host cell nucleus
L	0046872	molecular_function	metal ion binding
L	0075523	biological_process	viral translational frameshifting
L	0075526	biological_process	cap snatching
M	0003723	molecular_function	RNA binding
M	0004518	molecular_function	nuclease activity
M	0004519	molecular_function	endonuclease activity
M	0006351	biological_process	DNA-templated transcription
M	0016787	molecular_function	hydrolase activity
M	0030430	cellular_component	host cell cytoplasm
M	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
M	0039657	biological_process	symbiont-mediated suppression of host gene expression
M	0039694	biological_process	viral RNA genome replication
M	0042025	cellular_component	host cell nucleus
M	0046872	molecular_function	metal ion binding
M	0075523	biological_process	viral translational frameshifting
M	0075526	biological_process	cap snatching
N	0000166	molecular_function	nucleotide binding
N	0001172	biological_process	RNA-templated transcription
N	0003723	molecular_function	RNA binding
N	0003968	molecular_function	RNA-directed RNA polymerase activity
N	0006351	biological_process	DNA-templated transcription
N	0016740	molecular_function	transferase activity
N	0016779	molecular_function	nucleotidyltransferase activity
N	0019083	biological_process	viral transcription
N	0030430	cellular_component	host cell cytoplasm
N	0034062	molecular_function	5'-3' RNA polymerase activity
N	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
N	0039657	biological_process	symbiont-mediated suppression of host gene expression
N	0039694	biological_process	viral RNA genome replication
N	0042025	cellular_component	host cell nucleus
O	0001172	biological_process	RNA-templated transcription
O	0003723	molecular_function	RNA binding
O	0003968	molecular_function	RNA-directed RNA polymerase activity
O	0006351	biological_process	DNA-templated transcription
O	0006370	biological_process	7-methylguanosine mRNA capping
O	0006397	biological_process	mRNA processing
O	0019083	biological_process	viral transcription
O	0033650	cellular_component	host cell mitochondrion
O	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
O	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
O	0039657	biological_process	symbiont-mediated suppression of host gene expression
O	0039694	biological_process	viral RNA genome replication
O	0042025	cellular_component	host cell nucleus
O	0044423	cellular_component	virion component
O	0052031	biological_process	symbiont-mediated perturbation of host defense response
O	0052170	biological_process	symbiont-mediated suppression of host innate immune response
O	0075526	biological_process	cap snatching
P	0001172	biological_process	RNA-templated transcription
P	0003723	molecular_function	RNA binding
P	0003968	molecular_function	RNA-directed RNA polymerase activity
P	0006351	biological_process	DNA-templated transcription
P	0006370	biological_process	7-methylguanosine mRNA capping
P	0006397	biological_process	mRNA processing
P	0019083	biological_process	viral transcription
P	0033650	cellular_component	host cell mitochondrion
P	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
P	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
P	0039657	biological_process	symbiont-mediated suppression of host gene expression
P	0039694	biological_process	viral RNA genome replication
P	0042025	cellular_component	host cell nucleus
P	0044423	cellular_component	virion component
P	0052031	biological_process	symbiont-mediated perturbation of host defense response
P	0052170	biological_process	symbiont-mediated suppression of host innate immune response
P	0075526	biological_process	cap snatching
Q	0003723	molecular_function	RNA binding
Q	0004518	molecular_function	nuclease activity
Q	0004519	molecular_function	endonuclease activity
Q	0006351	biological_process	DNA-templated transcription
Q	0016787	molecular_function	hydrolase activity
Q	0030430	cellular_component	host cell cytoplasm
Q	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
Q	0039657	biological_process	symbiont-mediated suppression of host gene expression
Q	0039694	biological_process	viral RNA genome replication
Q	0042025	cellular_component	host cell nucleus
Q	0046872	molecular_function	metal ion binding
Q	0075523	biological_process	viral translational frameshifting
Q	0075526	biological_process	cap snatching
R	0000166	molecular_function	nucleotide binding
R	0001172	biological_process	RNA-templated transcription
R	0003723	molecular_function	RNA binding
R	0003968	molecular_function	RNA-directed RNA polymerase activity
R	0006351	biological_process	DNA-templated transcription
R	0016740	molecular_function	transferase activity
R	0016779	molecular_function	nucleotidyltransferase activity
R	0019083	biological_process	viral transcription
R	0030430	cellular_component	host cell cytoplasm
R	0034062	molecular_function	5'-3' RNA polymerase activity
R	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
R	0039657	biological_process	symbiont-mediated suppression of host gene expression
R	0039694	biological_process	viral RNA genome replication
R	0042025	cellular_component	host cell nucleus
S	0039675	biological_process	exit of virus from host cell nucleus through nuclear pore
S	0042025	cellular_component	host cell nucleus
S	0044423	cellular_component	virion component
T	0039675	biological_process	exit of virus from host cell nucleus through nuclear pore
T	0042025	cellular_component	host cell nucleus
T	0044423	cellular_component	virion component
U	0039675	biological_process	exit of virus from host cell nucleus through nuclear pore
U	0042025	cellular_component	host cell nucleus
U	0044423	cellular_component	virion component
V	0039675	biological_process	exit of virus from host cell nucleus through nuclear pore
V	0042025	cellular_component	host cell nucleus
V	0044423	cellular_component	virion component
W	0039675	biological_process	exit of virus from host cell nucleus through nuclear pore
W	0042025	cellular_component	host cell nucleus
W	0044423	cellular_component	virion component
X	0039675	biological_process	exit of virus from host cell nucleus through nuclear pore
X	0042025	cellular_component	host cell nucleus
X	0044423	cellular_component	virion component

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	90
Details	Motif: {"description":"Nuclear localization signal 1 (NLS1)","evidences":[{"source":"UniProtKB","id":"P03433","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	378
Details	Motif: {"description":"Nuclear localization signal 2 (NLS2)","evidences":[{"source":"UniProtKB","id":"P03433","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1182
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"HAMAP-Rule","id":"MF_04065","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	192
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	42
Details	Region: {"description":"Promoter-binding site","evidences":[{"source":"HAMAP-Rule","id":"MF_04065","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	54
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	9
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"HAMAP-Rule","id":"MF_04062","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	108
Details	Motif: {"description":"Nuclear export signal","evidences":[{"source":"HAMAP-Rule","id":"MF_04067","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---