8Y6O

Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP part

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000244	biological_process	spliceosomal tri-snRNP complex assembly
a	0000245	biological_process	spliceosomal complex assembly
a	0000387	biological_process	spliceosomal snRNP assembly
a	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
a	0000398	biological_process	mRNA splicing, via spliceosome
a	0003723	molecular_function	RNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005681	cellular_component	spliceosomal complex
a	0005682	cellular_component	U5 snRNP
a	0005683	cellular_component	U7 snRNP
a	0005684	cellular_component	U2-type spliceosomal complex
a	0005685	cellular_component	U1 snRNP
a	0005686	cellular_component	U2 snRNP
a	0005687	cellular_component	U4 snRNP
a	0005689	cellular_component	U12-type spliceosomal complex
a	0005697	cellular_component	telomerase holoenzyme complex
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0006397	biological_process	mRNA processing
a	0006479	biological_process	protein methylation
a	0008380	biological_process	RNA splicing
a	0030532	cellular_component	small nuclear ribonucleoprotein complex
a	0034709	cellular_component	methylosome
a	0034719	cellular_component	SMN-Sm protein complex
a	0036261	biological_process	7-methylguanosine cap hypermethylation
a	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
a	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
a	0070034	molecular_function	telomerase RNA binding
a	0070990	molecular_function	snRNP binding
a	0071004	cellular_component	U2-type prespliceosome
a	0071005	cellular_component	U2-type precatalytic spliceosome
a	0071007	cellular_component	U2-type catalytic step 2 spliceosome
a	0071013	cellular_component	catalytic step 2 spliceosome
a	0071045	biological_process	nuclear histone mRNA catabolic process
a	0071204	cellular_component	histone pre-mRNA 3'end processing complex
a	0071208	molecular_function	histone pre-mRNA DCP binding
a	1903241	biological_process	U2-type prespliceosome assembly
a	1990446	molecular_function	U1 snRNP binding
a	1990447	molecular_function	U2 snRNP binding
a	1990904	cellular_component	ribonucleoprotein complex
b	0000243	cellular_component	commitment complex
b	0000244	biological_process	spliceosomal tri-snRNP complex assembly
b	0000245	biological_process	spliceosomal complex assembly
b	0000387	biological_process	spliceosomal snRNP assembly
b	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005681	cellular_component	spliceosomal complex
b	0005682	cellular_component	U5 snRNP
b	0005684	cellular_component	U2-type spliceosomal complex
b	0005685	cellular_component	U1 snRNP
b	0005686	cellular_component	U2 snRNP
b	0005687	cellular_component	U4 snRNP
b	0005689	cellular_component	U12-type spliceosomal complex
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0006396	biological_process	RNA processing
b	0006397	biological_process	mRNA processing
b	0008380	biological_process	RNA splicing
b	0030532	cellular_component	small nuclear ribonucleoprotein complex
b	0034709	cellular_component	methylosome
b	0034715	cellular_component	pICln-Sm protein complex
b	0034719	cellular_component	SMN-Sm protein complex
b	0036261	biological_process	7-methylguanosine cap hypermethylation
b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
b	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
b	0071005	cellular_component	U2-type precatalytic spliceosome
b	0071007	cellular_component	U2-type catalytic step 2 spliceosome
b	0071011	cellular_component	precatalytic spliceosome
b	0071013	cellular_component	catalytic step 2 spliceosome
b	0097526	cellular_component	spliceosomal tri-snRNP complex
b	1903241	biological_process	U2-type prespliceosome assembly
b	1990446	molecular_function	U1 snRNP binding
b	1990904	cellular_component	ribonucleoprotein complex
c	0000244	biological_process	spliceosomal tri-snRNP complex assembly
c	0000245	biological_process	spliceosomal complex assembly
c	0000387	biological_process	spliceosomal snRNP assembly
c	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
c	0000398	biological_process	mRNA splicing, via spliceosome
c	0003723	molecular_function	RNA binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005681	cellular_component	spliceosomal complex
c	0005682	cellular_component	U5 snRNP
c	0005684	cellular_component	U2-type spliceosomal complex
c	0005685	cellular_component	U1 snRNP
c	0005686	cellular_component	U2 snRNP
c	0005687	cellular_component	U4 snRNP
c	0005689	cellular_component	U12-type spliceosomal complex
c	0005829	cellular_component	cytosol
c	0006397	biological_process	mRNA processing
c	0008380	biological_process	RNA splicing
c	0030532	cellular_component	small nuclear ribonucleoprotein complex
c	0034709	cellular_component	methylosome
c	0034715	cellular_component	pICln-Sm protein complex
c	0034719	cellular_component	SMN-Sm protein complex
c	0036261	biological_process	7-methylguanosine cap hypermethylation
c	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
c	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
c	0070062	cellular_component	extracellular exosome
c	0071005	cellular_component	U2-type precatalytic spliceosome
c	0071007	cellular_component	U2-type catalytic step 2 spliceosome
c	0071011	cellular_component	precatalytic spliceosome
c	0071013	cellular_component	catalytic step 2 spliceosome
c	0097525	cellular_component	spliceosomal snRNP complex
c	1903241	biological_process	U2-type prespliceosome assembly
c	1990904	cellular_component	ribonucleoprotein complex
C	0000244	biological_process	spliceosomal tri-snRNP complex assembly
C	0000375	biological_process	RNA splicing, via transesterification reactions
C	0000387	biological_process	spliceosomal snRNP assembly
C	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005681	cellular_component	spliceosomal complex
C	0005682	cellular_component	U5 snRNP
C	0006397	biological_process	mRNA processing
C	0008233	molecular_function	peptidase activity
C	0008237	molecular_function	metallopeptidase activity
C	0008380	biological_process	RNA splicing
C	0016020	cellular_component	membrane
C	0016607	cellular_component	nuclear speck
C	0017070	molecular_function	U6 snRNA binding
C	0030532	cellular_component	small nuclear ribonucleoprotein complex
C	0030619	molecular_function	U1 snRNA binding
C	0030620	molecular_function	U2 snRNA binding
C	0030623	molecular_function	U5 snRNA binding
C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
C	0070530	molecular_function	K63-linked polyubiquitin modification-dependent protein binding
C	0071005	cellular_component	U2-type precatalytic spliceosome
C	0071006	cellular_component	U2-type catalytic step 1 spliceosome
C	0071007	cellular_component	U2-type catalytic step 2 spliceosome
C	0071013	cellular_component	catalytic step 2 spliceosome
C	0071222	biological_process	cellular response to lipopolysaccharide
C	0071356	biological_process	cellular response to tumor necrosis factor
C	0097157	molecular_function	pre-mRNA intronic binding
C	0140492	molecular_function	metal-dependent deubiquitinase activity
C	1990904	cellular_component	ribonucleoprotein complex
d	0000243	cellular_component	commitment complex
d	0000244	biological_process	spliceosomal tri-snRNP complex assembly
d	0000245	biological_process	spliceosomal complex assembly
d	0000387	biological_process	spliceosomal snRNP assembly
d	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
d	0000398	biological_process	mRNA splicing, via spliceosome
d	0003723	molecular_function	RNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005681	cellular_component	spliceosomal complex
d	0005682	cellular_component	U5 snRNP
d	0005683	cellular_component	U7 snRNP
d	0005684	cellular_component	U2-type spliceosomal complex
d	0005685	cellular_component	U1 snRNP
d	0005686	cellular_component	U2 snRNP
d	0005687	cellular_component	U4 snRNP
d	0005689	cellular_component	U12-type spliceosomal complex
d	0005697	cellular_component	telomerase holoenzyme complex
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0006396	biological_process	RNA processing
d	0006397	biological_process	mRNA processing
d	0006479	biological_process	protein methylation
d	0008380	biological_process	RNA splicing
d	0016604	cellular_component	nuclear body
d	0019899	molecular_function	enzyme binding
d	0030532	cellular_component	small nuclear ribonucleoprotein complex
d	0034709	cellular_component	methylosome
d	0034715	cellular_component	pICln-Sm protein complex
d	0034719	cellular_component	SMN-Sm protein complex
d	0036261	biological_process	7-methylguanosine cap hypermethylation
d	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
d	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
d	0070034	molecular_function	telomerase RNA binding
d	0071005	cellular_component	U2-type precatalytic spliceosome
d	0071007	cellular_component	U2-type catalytic step 2 spliceosome
d	0071011	cellular_component	precatalytic spliceosome
d	0071013	cellular_component	catalytic step 2 spliceosome
d	0071045	biological_process	nuclear histone mRNA catabolic process
d	0071208	molecular_function	histone pre-mRNA DCP binding
d	0071209	molecular_function	U7 snRNA binding
d	0097526	cellular_component	spliceosomal tri-snRNP complex
d	1903241	biological_process	U2-type prespliceosome assembly
d	1990904	cellular_component	ribonucleoprotein complex
D	0000166	molecular_function	nucleotide binding
D	0000244	biological_process	spliceosomal tri-snRNP complex assembly
D	0000387	biological_process	spliceosomal snRNP assembly
D	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0003723	molecular_function	RNA binding
D	0003924	molecular_function	GTPase activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005681	cellular_component	spliceosomal complex
D	0005829	cellular_component	cytosol
D	0006397	biological_process	mRNA processing
D	0008380	biological_process	RNA splicing
D	0015030	cellular_component	Cajal body
D	0016020	cellular_component	membrane
D	0016607	cellular_component	nuclear speck
D	0030623	molecular_function	U5 snRNA binding
D	0042220	biological_process	response to cocaine
D	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
D	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
D	0071005	cellular_component	U2-type precatalytic spliceosome
D	0071007	cellular_component	U2-type catalytic step 2 spliceosome
D	0071013	cellular_component	catalytic step 2 spliceosome
D	0071466	biological_process	cellular response to xenobiotic stimulus
e	0000244	biological_process	spliceosomal tri-snRNP complex assembly
e	0000245	biological_process	spliceosomal complex assembly
e	0000387	biological_process	spliceosomal snRNP assembly
e	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
e	0000398	biological_process	mRNA splicing, via spliceosome
e	0003723	molecular_function	RNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005681	cellular_component	spliceosomal complex
e	0005682	cellular_component	U5 snRNP
e	0005683	cellular_component	U7 snRNP
e	0005684	cellular_component	U2-type spliceosomal complex
e	0005685	cellular_component	U1 snRNP
e	0005686	cellular_component	U2 snRNP
e	0005687	cellular_component	U4 snRNP
e	0005689	cellular_component	U12-type spliceosomal complex
e	0005697	cellular_component	telomerase holoenzyme complex
e	0005829	cellular_component	cytosol
e	0006397	biological_process	mRNA processing
e	0008380	biological_process	RNA splicing
e	0030532	cellular_component	small nuclear ribonucleoprotein complex
e	0034709	cellular_component	methylosome
e	0034715	cellular_component	pICln-Sm protein complex
e	0034719	cellular_component	SMN-Sm protein complex
e	0036261	biological_process	7-methylguanosine cap hypermethylation
e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
e	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
e	0071005	cellular_component	U2-type precatalytic spliceosome
e	0071007	cellular_component	U2-type catalytic step 2 spliceosome
e	0071011	cellular_component	precatalytic spliceosome
e	0071013	cellular_component	catalytic step 2 spliceosome
e	0071045	biological_process	nuclear histone mRNA catabolic process
e	1903241	biological_process	U2-type prespliceosome assembly
e	1990904	cellular_component	ribonucleoprotein complex
E	0000166	molecular_function	nucleotide binding
E	0000244	biological_process	spliceosomal tri-snRNP complex assembly
E	0000354	biological_process	cis assembly of pre-catalytic spliceosome
E	0000387	biological_process	spliceosomal snRNP assembly
E	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0001649	biological_process	osteoblast differentiation
E	0003676	molecular_function	nucleic acid binding
E	0003723	molecular_function	RNA binding
E	0003724	molecular_function	RNA helicase activity
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005681	cellular_component	spliceosomal complex
E	0005682	cellular_component	U5 snRNP
E	0006397	biological_process	mRNA processing
E	0008380	biological_process	RNA splicing
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0030532	cellular_component	small nuclear ribonucleoprotein complex
E	0042802	molecular_function	identical protein binding
E	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
E	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
E	0071005	cellular_component	U2-type precatalytic spliceosome
E	0071006	cellular_component	U2-type catalytic step 1 spliceosome
E	0071013	cellular_component	catalytic step 2 spliceosome
f	0000244	biological_process	spliceosomal tri-snRNP complex assembly
f	0000245	biological_process	spliceosomal complex assembly
f	0000387	biological_process	spliceosomal snRNP assembly
f	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
f	0000398	biological_process	mRNA splicing, via spliceosome
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005681	cellular_component	spliceosomal complex
f	0005683	cellular_component	U7 snRNP
f	0005684	cellular_component	U2-type spliceosomal complex
f	0005685	cellular_component	U1 snRNP
f	0005687	cellular_component	U4 snRNP
f	0005689	cellular_component	U12-type spliceosomal complex
f	0005829	cellular_component	cytosol
f	0006397	biological_process	mRNA processing
f	0008380	biological_process	RNA splicing
f	0022618	biological_process	protein-RNA complex assembly
f	0030532	cellular_component	small nuclear ribonucleoprotein complex
f	0034709	cellular_component	methylosome
f	0034715	cellular_component	pICln-Sm protein complex
f	0034719	cellular_component	SMN-Sm protein complex
f	0036261	biological_process	7-methylguanosine cap hypermethylation
f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
f	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
f	0071005	cellular_component	U2-type precatalytic spliceosome
f	0071007	cellular_component	U2-type catalytic step 2 spliceosome
f	0071013	cellular_component	catalytic step 2 spliceosome
f	0071045	biological_process	nuclear histone mRNA catabolic process
f	1903241	biological_process	U2-type prespliceosome assembly
f	1990904	cellular_component	ribonucleoprotein complex
F	0000244	biological_process	spliceosomal tri-snRNP complex assembly
F	0000375	biological_process	RNA splicing, via transesterification reactions
F	0000387	biological_process	spliceosomal snRNP assembly
F	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005681	cellular_component	spliceosomal complex
F	0005682	cellular_component	U5 snRNP
F	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
F	0006396	biological_process	RNA processing
F	0006397	biological_process	mRNA processing
F	0008380	biological_process	RNA splicing
F	0016607	cellular_component	nuclear speck
F	0071007	cellular_component	U2-type catalytic step 2 spliceosome
F	0071013	cellular_component	catalytic step 2 spliceosome
g	0000244	biological_process	spliceosomal tri-snRNP complex assembly
g	0000245	biological_process	spliceosomal complex assembly
g	0000387	biological_process	spliceosomal snRNP assembly
g	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
g	0000398	biological_process	mRNA splicing, via spliceosome
g	0003723	molecular_function	RNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005681	cellular_component	spliceosomal complex
g	0005682	cellular_component	U5 snRNP
g	0005683	cellular_component	U7 snRNP
g	0005684	cellular_component	U2-type spliceosomal complex
g	0005685	cellular_component	U1 snRNP
g	0005686	cellular_component	U2 snRNP
g	0005687	cellular_component	U4 snRNP
g	0005689	cellular_component	U12-type spliceosomal complex
g	0005829	cellular_component	cytosol
g	0006397	biological_process	mRNA processing
g	0008380	biological_process	RNA splicing
g	0030532	cellular_component	small nuclear ribonucleoprotein complex
g	0034709	cellular_component	methylosome
g	0034719	cellular_component	SMN-Sm protein complex
g	0036261	biological_process	7-methylguanosine cap hypermethylation
g	0043186	cellular_component	P granule
g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
g	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
g	0071004	cellular_component	U2-type prespliceosome
g	0071005	cellular_component	U2-type precatalytic spliceosome
g	0071007	cellular_component	U2-type catalytic step 2 spliceosome
g	0071011	cellular_component	precatalytic spliceosome
g	0071013	cellular_component	catalytic step 2 spliceosome
g	0071045	biological_process	nuclear histone mRNA catabolic process
g	0097526	cellular_component	spliceosomal tri-snRNP complex
g	1903241	biological_process	U2-type prespliceosome assembly
g	1990904	cellular_component	ribonucleoprotein complex
G	0000244	biological_process	spliceosomal tri-snRNP complex assembly
G	0000245	biological_process	spliceosomal complex assembly
G	0000375	biological_process	RNA splicing, via transesterification reactions
G	0000387	biological_process	spliceosomal snRNP assembly
G	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
G	0000398	biological_process	mRNA splicing, via spliceosome
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005681	cellular_component	spliceosomal complex
G	0005682	cellular_component	U5 snRNP
G	0006396	biological_process	RNA processing
G	0006397	biological_process	mRNA processing
G	0006403	biological_process	RNA localization
G	0008380	biological_process	RNA splicing
G	0016020	cellular_component	membrane
G	0016607	cellular_component	nuclear speck
G	0030674	molecular_function	protein-macromolecule adaptor activity
G	0042802	molecular_function	identical protein binding
G	0043021	molecular_function	ribonucleoprotein complex binding
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
G	0071005	cellular_component	U2-type precatalytic spliceosome
G	0071013	cellular_component	catalytic step 2 spliceosome
h	0000244	biological_process	spliceosomal tri-snRNP complex assembly
h	0000245	biological_process	spliceosomal complex assembly
h	0000387	biological_process	spliceosomal snRNP assembly
h	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0003723	molecular_function	RNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005681	cellular_component	spliceosomal complex
h	0005682	cellular_component	U5 snRNP
h	0005683	cellular_component	U7 snRNP
h	0005684	cellular_component	U2-type spliceosomal complex
h	0005685	cellular_component	U1 snRNP
h	0005686	cellular_component	U2 snRNP
h	0005687	cellular_component	U4 snRNP
h	0005689	cellular_component	U12-type spliceosomal complex
h	0005697	cellular_component	telomerase holoenzyme complex
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0006397	biological_process	mRNA processing
h	0006479	biological_process	protein methylation
h	0008380	biological_process	RNA splicing
h	0030532	cellular_component	small nuclear ribonucleoprotein complex
h	0034709	cellular_component	methylosome
h	0034719	cellular_component	SMN-Sm protein complex
h	0036261	biological_process	7-methylguanosine cap hypermethylation
h	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
h	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
h	0070034	molecular_function	telomerase RNA binding
h	0070990	molecular_function	snRNP binding
h	0071004	cellular_component	U2-type prespliceosome
h	0071005	cellular_component	U2-type precatalytic spliceosome
h	0071007	cellular_component	U2-type catalytic step 2 spliceosome
h	0071013	cellular_component	catalytic step 2 spliceosome
h	0071045	biological_process	nuclear histone mRNA catabolic process
h	0071204	cellular_component	histone pre-mRNA 3'end processing complex
h	0071208	molecular_function	histone pre-mRNA DCP binding
h	1903241	biological_process	U2-type prespliceosome assembly
h	1990446	molecular_function	U1 snRNP binding
h	1990447	molecular_function	U2 snRNP binding
h	1990904	cellular_component	ribonucleoprotein complex
H	0000244	biological_process	spliceosomal tri-snRNP complex assembly
H	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
H	0000398	biological_process	mRNA splicing, via spliceosome
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005681	cellular_component	spliceosomal complex
H	0005682	cellular_component	U5 snRNP
H	0006397	biological_process	mRNA processing
H	0008380	biological_process	RNA splicing
H	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
i	0000243	cellular_component	commitment complex
i	0000244	biological_process	spliceosomal tri-snRNP complex assembly
i	0000245	biological_process	spliceosomal complex assembly
i	0000387	biological_process	spliceosomal snRNP assembly
i	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
i	0000398	biological_process	mRNA splicing, via spliceosome
i	0003723	molecular_function	RNA binding
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005681	cellular_component	spliceosomal complex
i	0005682	cellular_component	U5 snRNP
i	0005684	cellular_component	U2-type spliceosomal complex
i	0005685	cellular_component	U1 snRNP
i	0005686	cellular_component	U2 snRNP
i	0005687	cellular_component	U4 snRNP
i	0005689	cellular_component	U12-type spliceosomal complex
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0006396	biological_process	RNA processing
i	0006397	biological_process	mRNA processing
i	0008380	biological_process	RNA splicing
i	0030532	cellular_component	small nuclear ribonucleoprotein complex
i	0034709	cellular_component	methylosome
i	0034715	cellular_component	pICln-Sm protein complex
i	0034719	cellular_component	SMN-Sm protein complex
i	0036261	biological_process	7-methylguanosine cap hypermethylation
i	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
i	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
i	0071005	cellular_component	U2-type precatalytic spliceosome
i	0071007	cellular_component	U2-type catalytic step 2 spliceosome
i	0071011	cellular_component	precatalytic spliceosome
i	0071013	cellular_component	catalytic step 2 spliceosome
i	0097526	cellular_component	spliceosomal tri-snRNP complex
i	1903241	biological_process	U2-type prespliceosome assembly
i	1990446	molecular_function	U1 snRNP binding
i	1990904	cellular_component	ribonucleoprotein complex
I	0000166	molecular_function	nucleotide binding
I	0000244	biological_process	spliceosomal tri-snRNP complex assembly
I	0000354	biological_process	cis assembly of pre-catalytic spliceosome
I	0000375	biological_process	RNA splicing, via transesterification reactions
I	0000387	biological_process	spliceosomal snRNP assembly
I	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
I	0000398	biological_process	mRNA splicing, via spliceosome
I	0000785	cellular_component	chromatin
I	0003676	molecular_function	nucleic acid binding
I	0003723	molecular_function	RNA binding
I	0003724	molecular_function	RNA helicase activity
I	0003729	molecular_function	mRNA binding
I	0004386	molecular_function	helicase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005681	cellular_component	spliceosomal complex
I	0005682	cellular_component	U5 snRNP
I	0005694	cellular_component	chromosome
I	0005730	cellular_component	nucleolus
I	0006397	biological_process	mRNA processing
I	0008380	biological_process	RNA splicing
I	0016787	molecular_function	hydrolase activity
I	0016887	molecular_function	ATP hydrolysis activity
I	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
I	0062176	biological_process	R-loop processing
I	0070062	cellular_component	extracellular exosome
I	0071013	cellular_component	catalytic step 2 spliceosome
j	0000244	biological_process	spliceosomal tri-snRNP complex assembly
j	0000245	biological_process	spliceosomal complex assembly
j	0000387	biological_process	spliceosomal snRNP assembly
j	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
j	0000398	biological_process	mRNA splicing, via spliceosome
j	0003723	molecular_function	RNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005681	cellular_component	spliceosomal complex
j	0005682	cellular_component	U5 snRNP
j	0005684	cellular_component	U2-type spliceosomal complex
j	0005685	cellular_component	U1 snRNP
j	0005686	cellular_component	U2 snRNP
j	0005687	cellular_component	U4 snRNP
j	0005689	cellular_component	U12-type spliceosomal complex
j	0005829	cellular_component	cytosol
j	0006397	biological_process	mRNA processing
j	0008380	biological_process	RNA splicing
j	0030532	cellular_component	small nuclear ribonucleoprotein complex
j	0034709	cellular_component	methylosome
j	0034715	cellular_component	pICln-Sm protein complex
j	0034719	cellular_component	SMN-Sm protein complex
j	0036261	biological_process	7-methylguanosine cap hypermethylation
j	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
j	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
j	0070062	cellular_component	extracellular exosome
j	0071005	cellular_component	U2-type precatalytic spliceosome
j	0071007	cellular_component	U2-type catalytic step 2 spliceosome
j	0071011	cellular_component	precatalytic spliceosome
j	0071013	cellular_component	catalytic step 2 spliceosome
j	0097525	cellular_component	spliceosomal snRNP complex
j	1903241	biological_process	U2-type prespliceosome assembly
j	1990904	cellular_component	ribonucleoprotein complex
k	0000243	cellular_component	commitment complex
k	0000244	biological_process	spliceosomal tri-snRNP complex assembly
k	0000245	biological_process	spliceosomal complex assembly
k	0000387	biological_process	spliceosomal snRNP assembly
k	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
k	0000398	biological_process	mRNA splicing, via spliceosome
k	0003723	molecular_function	RNA binding
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005681	cellular_component	spliceosomal complex
k	0005682	cellular_component	U5 snRNP
k	0005683	cellular_component	U7 snRNP
k	0005684	cellular_component	U2-type spliceosomal complex
k	0005685	cellular_component	U1 snRNP
k	0005686	cellular_component	U2 snRNP
k	0005687	cellular_component	U4 snRNP
k	0005689	cellular_component	U12-type spliceosomal complex
k	0005697	cellular_component	telomerase holoenzyme complex
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0006396	biological_process	RNA processing
k	0006397	biological_process	mRNA processing
k	0006479	biological_process	protein methylation
k	0008380	biological_process	RNA splicing
k	0016604	cellular_component	nuclear body
k	0019899	molecular_function	enzyme binding
k	0030532	cellular_component	small nuclear ribonucleoprotein complex
k	0034709	cellular_component	methylosome
k	0034715	cellular_component	pICln-Sm protein complex
k	0034719	cellular_component	SMN-Sm protein complex
k	0036261	biological_process	7-methylguanosine cap hypermethylation
k	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
k	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
k	0070034	molecular_function	telomerase RNA binding
k	0071005	cellular_component	U2-type precatalytic spliceosome
k	0071007	cellular_component	U2-type catalytic step 2 spliceosome
k	0071011	cellular_component	precatalytic spliceosome
k	0071013	cellular_component	catalytic step 2 spliceosome
k	0071045	biological_process	nuclear histone mRNA catabolic process
k	0071208	molecular_function	histone pre-mRNA DCP binding
k	0071209	molecular_function	U7 snRNA binding
k	0097526	cellular_component	spliceosomal tri-snRNP complex
k	1903241	biological_process	U2-type prespliceosome assembly
k	1990904	cellular_component	ribonucleoprotein complex
l	0000244	biological_process	spliceosomal tri-snRNP complex assembly
l	0000245	biological_process	spliceosomal complex assembly
l	0000387	biological_process	spliceosomal snRNP assembly
l	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
l	0000398	biological_process	mRNA splicing, via spliceosome
l	0003723	molecular_function	RNA binding
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005681	cellular_component	spliceosomal complex
l	0005682	cellular_component	U5 snRNP
l	0005683	cellular_component	U7 snRNP
l	0005684	cellular_component	U2-type spliceosomal complex
l	0005685	cellular_component	U1 snRNP
l	0005686	cellular_component	U2 snRNP
l	0005687	cellular_component	U4 snRNP
l	0005689	cellular_component	U12-type spliceosomal complex
l	0005697	cellular_component	telomerase holoenzyme complex
l	0005829	cellular_component	cytosol
l	0006397	biological_process	mRNA processing
l	0008380	biological_process	RNA splicing
l	0030532	cellular_component	small nuclear ribonucleoprotein complex
l	0034709	cellular_component	methylosome
l	0034715	cellular_component	pICln-Sm protein complex
l	0034719	cellular_component	SMN-Sm protein complex
l	0036261	biological_process	7-methylguanosine cap hypermethylation
l	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
l	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
l	0071005	cellular_component	U2-type precatalytic spliceosome
l	0071007	cellular_component	U2-type catalytic step 2 spliceosome
l	0071011	cellular_component	precatalytic spliceosome
l	0071013	cellular_component	catalytic step 2 spliceosome
l	0071045	biological_process	nuclear histone mRNA catabolic process
l	1903241	biological_process	U2-type prespliceosome assembly
l	1990904	cellular_component	ribonucleoprotein complex
L	0000244	biological_process	spliceosomal tri-snRNP complex assembly
L	0000387	biological_process	spliceosomal snRNP assembly
L	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0003723	molecular_function	RNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005681	cellular_component	spliceosomal complex
L	0005684	cellular_component	U2-type spliceosomal complex
L	0005687	cellular_component	U4 snRNP
L	0005690	cellular_component	U4atac snRNP
L	0006397	biological_process	mRNA processing
L	0008380	biological_process	RNA splicing
L	0015030	cellular_component	Cajal body
L	0016607	cellular_component	nuclear speck
L	0030621	molecular_function	U4 snRNA binding
L	0030622	molecular_function	U4atac snRNA binding
L	0030674	molecular_function	protein-macromolecule adaptor activity
L	0042802	molecular_function	identical protein binding
L	0043021	molecular_function	ribonucleoprotein complex binding
L	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
L	0048254	biological_process	snoRNA localization
L	0070990	molecular_function	snRNP binding
L	0071005	cellular_component	U2-type precatalytic spliceosome
L	0071011	cellular_component	precatalytic spliceosome
L	0071166	biological_process	ribonucleoprotein complex localization
L	0071339	cellular_component	MLL1 complex
L	0097526	cellular_component	spliceosomal tri-snRNP complex
L	1990904	cellular_component	ribonucleoprotein complex
m	0000244	biological_process	spliceosomal tri-snRNP complex assembly
m	0000245	biological_process	spliceosomal complex assembly
m	0000387	biological_process	spliceosomal snRNP assembly
m	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
m	0000398	biological_process	mRNA splicing, via spliceosome
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005681	cellular_component	spliceosomal complex
m	0005683	cellular_component	U7 snRNP
m	0005684	cellular_component	U2-type spliceosomal complex
m	0005685	cellular_component	U1 snRNP
m	0005687	cellular_component	U4 snRNP
m	0005689	cellular_component	U12-type spliceosomal complex
m	0005829	cellular_component	cytosol
m	0006397	biological_process	mRNA processing
m	0008380	biological_process	RNA splicing
m	0022618	biological_process	protein-RNA complex assembly
m	0030532	cellular_component	small nuclear ribonucleoprotein complex
m	0034709	cellular_component	methylosome
m	0034715	cellular_component	pICln-Sm protein complex
m	0034719	cellular_component	SMN-Sm protein complex
m	0036261	biological_process	7-methylguanosine cap hypermethylation
m	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
m	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
m	0071005	cellular_component	U2-type precatalytic spliceosome
m	0071007	cellular_component	U2-type catalytic step 2 spliceosome
m	0071013	cellular_component	catalytic step 2 spliceosome
m	0071045	biological_process	nuclear histone mRNA catabolic process
m	1903241	biological_process	U2-type prespliceosome assembly
m	1990904	cellular_component	ribonucleoprotein complex
M	0000244	biological_process	spliceosomal tri-snRNP complex assembly
M	0000245	biological_process	spliceosomal complex assembly
M	0000375	biological_process	RNA splicing, via transesterification reactions
M	0000387	biological_process	spliceosomal snRNP assembly
M	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
M	0000398	biological_process	mRNA splicing, via spliceosome
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005681	cellular_component	spliceosomal complex
M	0006396	biological_process	RNA processing
M	0006397	biological_process	mRNA processing
M	0008380	biological_process	RNA splicing
M	0015030	cellular_component	Cajal body
M	0016607	cellular_component	nuclear speck
M	0017070	molecular_function	U6 snRNA binding
M	0030621	molecular_function	U4 snRNA binding
M	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
M	0071001	cellular_component	U4/U6 snRNP
M	0071005	cellular_component	U2-type precatalytic spliceosome
M	0097525	cellular_component	spliceosomal snRNP complex
n	0000244	biological_process	spliceosomal tri-snRNP complex assembly
n	0000245	biological_process	spliceosomal complex assembly
n	0000387	biological_process	spliceosomal snRNP assembly
n	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
n	0000398	biological_process	mRNA splicing, via spliceosome
n	0003723	molecular_function	RNA binding
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005681	cellular_component	spliceosomal complex
n	0005682	cellular_component	U5 snRNP
n	0005683	cellular_component	U7 snRNP
n	0005684	cellular_component	U2-type spliceosomal complex
n	0005685	cellular_component	U1 snRNP
n	0005686	cellular_component	U2 snRNP
n	0005687	cellular_component	U4 snRNP
n	0005689	cellular_component	U12-type spliceosomal complex
n	0005829	cellular_component	cytosol
n	0006397	biological_process	mRNA processing
n	0008380	biological_process	RNA splicing
n	0030532	cellular_component	small nuclear ribonucleoprotein complex
n	0034709	cellular_component	methylosome
n	0034719	cellular_component	SMN-Sm protein complex
n	0036261	biological_process	7-methylguanosine cap hypermethylation
n	0043186	cellular_component	P granule
n	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
n	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
n	0071004	cellular_component	U2-type prespliceosome
n	0071005	cellular_component	U2-type precatalytic spliceosome
n	0071007	cellular_component	U2-type catalytic step 2 spliceosome
n	0071011	cellular_component	precatalytic spliceosome
n	0071013	cellular_component	catalytic step 2 spliceosome
n	0071045	biological_process	nuclear histone mRNA catabolic process
n	0097526	cellular_component	spliceosomal tri-snRNP complex
n	1903241	biological_process	U2-type prespliceosome assembly
n	1990904	cellular_component	ribonucleoprotein complex
N	0000244	biological_process	spliceosomal tri-snRNP complex assembly
N	0000245	biological_process	spliceosomal complex assembly
N	0000375	biological_process	RNA splicing, via transesterification reactions
N	0000387	biological_process	spliceosomal snRNP assembly
N	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0003723	molecular_function	RNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005681	cellular_component	spliceosomal complex
N	0006397	biological_process	mRNA processing
N	0008380	biological_process	RNA splicing
N	0015030	cellular_component	Cajal body
N	0016607	cellular_component	nuclear speck
N	0032991	cellular_component	protein-containing complex
N	0042802	molecular_function	identical protein binding
N	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
N	0071005	cellular_component	U2-type precatalytic spliceosome
o	0000244	biological_process	spliceosomal tri-snRNP complex assembly
o	0000245	biological_process	spliceosomal complex assembly
o	0000387	biological_process	spliceosomal snRNP assembly
o	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
o	0000398	biological_process	mRNA splicing, via spliceosome
o	0003723	molecular_function	RNA binding
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005681	cellular_component	spliceosomal complex
o	0005682	cellular_component	U5 snRNP
o	0005683	cellular_component	U7 snRNP
o	0005684	cellular_component	U2-type spliceosomal complex
o	0005685	cellular_component	U1 snRNP
o	0005686	cellular_component	U2 snRNP
o	0005687	cellular_component	U4 snRNP
o	0005689	cellular_component	U12-type spliceosomal complex
o	0005697	cellular_component	telomerase holoenzyme complex
o	0005737	cellular_component	cytoplasm
o	0005829	cellular_component	cytosol
o	0006397	biological_process	mRNA processing
o	0006479	biological_process	protein methylation
o	0008380	biological_process	RNA splicing
o	0030532	cellular_component	small nuclear ribonucleoprotein complex
o	0034709	cellular_component	methylosome
o	0034719	cellular_component	SMN-Sm protein complex
o	0036261	biological_process	7-methylguanosine cap hypermethylation
o	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
o	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
o	0070034	molecular_function	telomerase RNA binding
o	0070990	molecular_function	snRNP binding
o	0071004	cellular_component	U2-type prespliceosome
o	0071005	cellular_component	U2-type precatalytic spliceosome
o	0071007	cellular_component	U2-type catalytic step 2 spliceosome
o	0071013	cellular_component	catalytic step 2 spliceosome
o	0071045	biological_process	nuclear histone mRNA catabolic process
o	0071204	cellular_component	histone pre-mRNA 3'end processing complex
o	0071208	molecular_function	histone pre-mRNA DCP binding
o	1903241	biological_process	U2-type prespliceosome assembly
o	1990446	molecular_function	U1 snRNP binding
o	1990447	molecular_function	U2 snRNP binding
o	1990904	cellular_component	ribonucleoprotein complex
O	0000244	biological_process	spliceosomal tri-snRNP complex assembly
O	0000245	biological_process	spliceosomal complex assembly
O	0000387	biological_process	spliceosomal snRNP assembly
O	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0000451	biological_process	rRNA 2'-O-methylation
O	0000492	biological_process	box C/D snoRNP assembly
O	0001651	cellular_component	dense fibrillar component
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005681	cellular_component	spliceosomal complex
O	0005690	cellular_component	U4atac snRNP
O	0005730	cellular_component	nucleolus
O	0006397	biological_process	mRNA processing
O	0008380	biological_process	RNA splicing
O	0016556	biological_process	mRNA modification
O	0030182	biological_process	neuron differentiation
O	0030490	biological_process	maturation of SSU-rRNA
O	0030515	molecular_function	snoRNA binding
O	0030621	molecular_function	U4 snRNA binding
O	0030622	molecular_function	U4atac snRNA binding
O	0031428	cellular_component	box C/D methylation guide snoRNP complex
O	0032040	cellular_component	small-subunit processome
O	0032991	cellular_component	protein-containing complex
O	0034511	molecular_function	U3 snoRNA binding
O	0034512	molecular_function	box C/D sno(s)RNA binding
O	0042254	biological_process	ribosome biogenesis
O	0042274	biological_process	ribosomal small subunit biogenesis
O	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
O	0051117	molecular_function	ATPase binding
O	0071005	cellular_component	U2-type precatalytic spliceosome
O	0071011	cellular_component	precatalytic spliceosome
O	1990904	cellular_component	ribonucleoprotein complex
p	0000243	cellular_component	commitment complex
p	0000244	biological_process	spliceosomal tri-snRNP complex assembly
p	0000245	biological_process	spliceosomal complex assembly
p	0000387	biological_process	spliceosomal snRNP assembly
p	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
p	0000398	biological_process	mRNA splicing, via spliceosome
p	0003723	molecular_function	RNA binding
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0005681	cellular_component	spliceosomal complex
p	0005682	cellular_component	U5 snRNP
p	0005684	cellular_component	U2-type spliceosomal complex
p	0005685	cellular_component	U1 snRNP
p	0005686	cellular_component	U2 snRNP
p	0005687	cellular_component	U4 snRNP
p	0005689	cellular_component	U12-type spliceosomal complex
p	0005737	cellular_component	cytoplasm
p	0005829	cellular_component	cytosol
p	0006396	biological_process	RNA processing
p	0006397	biological_process	mRNA processing
p	0008380	biological_process	RNA splicing
p	0030532	cellular_component	small nuclear ribonucleoprotein complex
p	0034709	cellular_component	methylosome
p	0034715	cellular_component	pICln-Sm protein complex
p	0034719	cellular_component	SMN-Sm protein complex
p	0036261	biological_process	7-methylguanosine cap hypermethylation
p	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
p	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
p	0071005	cellular_component	U2-type precatalytic spliceosome
p	0071007	cellular_component	U2-type catalytic step 2 spliceosome
p	0071011	cellular_component	precatalytic spliceosome
p	0071013	cellular_component	catalytic step 2 spliceosome
p	0097526	cellular_component	spliceosomal tri-snRNP complex
p	1903241	biological_process	U2-type prespliceosome assembly
p	1990446	molecular_function	U1 snRNP binding
p	1990904	cellular_component	ribonucleoprotein complex
q	0000244	biological_process	spliceosomal tri-snRNP complex assembly
q	0000245	biological_process	spliceosomal complex assembly
q	0000387	biological_process	spliceosomal snRNP assembly
q	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
q	0000398	biological_process	mRNA splicing, via spliceosome
q	0003723	molecular_function	RNA binding
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005681	cellular_component	spliceosomal complex
q	0005682	cellular_component	U5 snRNP
q	0005684	cellular_component	U2-type spliceosomal complex
q	0005685	cellular_component	U1 snRNP
q	0005686	cellular_component	U2 snRNP
q	0005687	cellular_component	U4 snRNP
q	0005689	cellular_component	U12-type spliceosomal complex
q	0005829	cellular_component	cytosol
q	0006397	biological_process	mRNA processing
q	0008380	biological_process	RNA splicing
q	0030532	cellular_component	small nuclear ribonucleoprotein complex
q	0034709	cellular_component	methylosome
q	0034715	cellular_component	pICln-Sm protein complex
q	0034719	cellular_component	SMN-Sm protein complex
q	0036261	biological_process	7-methylguanosine cap hypermethylation
q	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
q	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
q	0070062	cellular_component	extracellular exosome
q	0071005	cellular_component	U2-type precatalytic spliceosome
q	0071007	cellular_component	U2-type catalytic step 2 spliceosome
q	0071011	cellular_component	precatalytic spliceosome
q	0071013	cellular_component	catalytic step 2 spliceosome
q	0097525	cellular_component	spliceosomal snRNP complex
q	1903241	biological_process	U2-type prespliceosome assembly
q	1990904	cellular_component	ribonucleoprotein complex
Q	0000166	molecular_function	nucleotide binding
Q	0000244	biological_process	spliceosomal tri-snRNP complex assembly
Q	0000387	biological_process	spliceosomal snRNP assembly
Q	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0000776	cellular_component	kinetochore
Q	0003723	molecular_function	RNA binding
Q	0004672	molecular_function	protein kinase activity
Q	0004674	molecular_function	protein serine/threonine kinase activity
Q	0005515	molecular_function	protein binding
Q	0005524	molecular_function	ATP binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005681	cellular_component	spliceosomal complex
Q	0005694	cellular_component	chromosome
Q	0006397	biological_process	mRNA processing
Q	0006468	biological_process	protein phosphorylation
Q	0008380	biological_process	RNA splicing
Q	0016301	molecular_function	kinase activity
Q	0016607	cellular_component	nuclear speck
Q	0016740	molecular_function	transferase activity
Q	0035332	biological_process	positive regulation of hippo signaling
Q	0045292	biological_process	mRNA cis splicing, via spliceosome
Q	0046827	biological_process	positive regulation of protein export from nucleus
Q	0071013	cellular_component	catalytic step 2 spliceosome
Q	0090266	biological_process	regulation of mitotic cell cycle spindle assembly checkpoint
Q	0106310	molecular_function	protein serine kinase activity
r	0000243	cellular_component	commitment complex
r	0000244	biological_process	spliceosomal tri-snRNP complex assembly
r	0000245	biological_process	spliceosomal complex assembly
r	0000387	biological_process	spliceosomal snRNP assembly
r	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
r	0000398	biological_process	mRNA splicing, via spliceosome
r	0003723	molecular_function	RNA binding
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0005681	cellular_component	spliceosomal complex
r	0005682	cellular_component	U5 snRNP
r	0005683	cellular_component	U7 snRNP
r	0005684	cellular_component	U2-type spliceosomal complex
r	0005685	cellular_component	U1 snRNP
r	0005686	cellular_component	U2 snRNP
r	0005687	cellular_component	U4 snRNP
r	0005689	cellular_component	U12-type spliceosomal complex
r	0005697	cellular_component	telomerase holoenzyme complex
r	0005737	cellular_component	cytoplasm
r	0005829	cellular_component	cytosol
r	0006396	biological_process	RNA processing
r	0006397	biological_process	mRNA processing
r	0006479	biological_process	protein methylation
r	0008380	biological_process	RNA splicing
r	0016604	cellular_component	nuclear body
r	0019899	molecular_function	enzyme binding
r	0030532	cellular_component	small nuclear ribonucleoprotein complex
r	0034709	cellular_component	methylosome
r	0034715	cellular_component	pICln-Sm protein complex
r	0034719	cellular_component	SMN-Sm protein complex
r	0036261	biological_process	7-methylguanosine cap hypermethylation
r	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
r	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
r	0070034	molecular_function	telomerase RNA binding
r	0071005	cellular_component	U2-type precatalytic spliceosome
r	0071007	cellular_component	U2-type catalytic step 2 spliceosome
r	0071011	cellular_component	precatalytic spliceosome
r	0071013	cellular_component	catalytic step 2 spliceosome
r	0071045	biological_process	nuclear histone mRNA catabolic process
r	0071208	molecular_function	histone pre-mRNA DCP binding
r	0071209	molecular_function	U7 snRNA binding
r	0097526	cellular_component	spliceosomal tri-snRNP complex
r	1903241	biological_process	U2-type prespliceosome assembly
r	1990904	cellular_component	ribonucleoprotein complex
R	0000244	biological_process	spliceosomal tri-snRNP complex assembly
R	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0005515	molecular_function	protein binding
R	0005813	cellular_component	centrosome
R	0006397	biological_process	mRNA processing
R	0008380	biological_process	RNA splicing
R	0010826	biological_process	negative regulation of centrosome duplication
R	0042176	biological_process	regulation of protein catabolic process
R	0051304	biological_process	chromosome separation
s	0000244	biological_process	spliceosomal tri-snRNP complex assembly
s	0000245	biological_process	spliceosomal complex assembly
s	0000387	biological_process	spliceosomal snRNP assembly
s	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
s	0000398	biological_process	mRNA splicing, via spliceosome
s	0003723	molecular_function	RNA binding
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0005681	cellular_component	spliceosomal complex
s	0005682	cellular_component	U5 snRNP
s	0005683	cellular_component	U7 snRNP
s	0005684	cellular_component	U2-type spliceosomal complex
s	0005685	cellular_component	U1 snRNP
s	0005686	cellular_component	U2 snRNP
s	0005687	cellular_component	U4 snRNP
s	0005689	cellular_component	U12-type spliceosomal complex
s	0005697	cellular_component	telomerase holoenzyme complex
s	0005829	cellular_component	cytosol
s	0006397	biological_process	mRNA processing
s	0008380	biological_process	RNA splicing
s	0030532	cellular_component	small nuclear ribonucleoprotein complex
s	0034709	cellular_component	methylosome
s	0034715	cellular_component	pICln-Sm protein complex
s	0034719	cellular_component	SMN-Sm protein complex
s	0036261	biological_process	7-methylguanosine cap hypermethylation
s	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
s	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
s	0071005	cellular_component	U2-type precatalytic spliceosome
s	0071007	cellular_component	U2-type catalytic step 2 spliceosome
s	0071011	cellular_component	precatalytic spliceosome
s	0071013	cellular_component	catalytic step 2 spliceosome
s	0071045	biological_process	nuclear histone mRNA catabolic process
s	1903241	biological_process	U2-type prespliceosome assembly
s	1990904	cellular_component	ribonucleoprotein complex
S	0000244	biological_process	spliceosomal tri-snRNP complex assembly
S	0000387	biological_process	spliceosomal snRNP assembly
S	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0000481	biological_process	maturation of 5S rRNA
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005681	cellular_component	spliceosomal complex
S	0005737	cellular_component	cytoplasm
S	0005794	cellular_component	Golgi apparatus
S	0005829	cellular_component	cytosol
S	0006397	biological_process	mRNA processing
S	0008380	biological_process	RNA splicing
S	0015030	cellular_component	Cajal body
S	0016607	cellular_component	nuclear speck
S	0045292	biological_process	mRNA cis splicing, via spliceosome
S	0045585	biological_process	positive regulation of cytotoxic T cell differentiation
S	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
S	0071005	cellular_component	U2-type precatalytic spliceosome
S	0071013	cellular_component	catalytic step 2 spliceosome
t	0000244	biological_process	spliceosomal tri-snRNP complex assembly
t	0000245	biological_process	spliceosomal complex assembly
t	0000387	biological_process	spliceosomal snRNP assembly
t	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
t	0000398	biological_process	mRNA splicing, via spliceosome
t	0003723	molecular_function	RNA binding
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005681	cellular_component	spliceosomal complex
t	0005683	cellular_component	U7 snRNP
t	0005684	cellular_component	U2-type spliceosomal complex
t	0005685	cellular_component	U1 snRNP
t	0005687	cellular_component	U4 snRNP
t	0005689	cellular_component	U12-type spliceosomal complex
t	0005829	cellular_component	cytosol
t	0006397	biological_process	mRNA processing
t	0008380	biological_process	RNA splicing
t	0022618	biological_process	protein-RNA complex assembly
t	0030532	cellular_component	small nuclear ribonucleoprotein complex
t	0034709	cellular_component	methylosome
t	0034715	cellular_component	pICln-Sm protein complex
t	0034719	cellular_component	SMN-Sm protein complex
t	0036261	biological_process	7-methylguanosine cap hypermethylation
t	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
t	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
t	0071005	cellular_component	U2-type precatalytic spliceosome
t	0071007	cellular_component	U2-type catalytic step 2 spliceosome
t	0071013	cellular_component	catalytic step 2 spliceosome
t	0071045	biological_process	nuclear histone mRNA catabolic process
t	1903241	biological_process	U2-type prespliceosome assembly
t	1990904	cellular_component	ribonucleoprotein complex
u	0000244	biological_process	spliceosomal tri-snRNP complex assembly
u	0000245	biological_process	spliceosomal complex assembly
u	0000387	biological_process	spliceosomal snRNP assembly
u	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
u	0000398	biological_process	mRNA splicing, via spliceosome
u	0003723	molecular_function	RNA binding
u	0005515	molecular_function	protein binding
u	0005634	cellular_component	nucleus
u	0005654	cellular_component	nucleoplasm
u	0005681	cellular_component	spliceosomal complex
u	0005682	cellular_component	U5 snRNP
u	0005683	cellular_component	U7 snRNP
u	0005684	cellular_component	U2-type spliceosomal complex
u	0005685	cellular_component	U1 snRNP
u	0005686	cellular_component	U2 snRNP
u	0005687	cellular_component	U4 snRNP
u	0005689	cellular_component	U12-type spliceosomal complex
u	0005829	cellular_component	cytosol
u	0006397	biological_process	mRNA processing
u	0008380	biological_process	RNA splicing
u	0030532	cellular_component	small nuclear ribonucleoprotein complex
u	0034709	cellular_component	methylosome
u	0034719	cellular_component	SMN-Sm protein complex
u	0036261	biological_process	7-methylguanosine cap hypermethylation
u	0043186	cellular_component	P granule
u	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
u	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
u	0071004	cellular_component	U2-type prespliceosome
u	0071005	cellular_component	U2-type precatalytic spliceosome
u	0071007	cellular_component	U2-type catalytic step 2 spliceosome
u	0071011	cellular_component	precatalytic spliceosome
u	0071013	cellular_component	catalytic step 2 spliceosome
u	0071045	biological_process	nuclear histone mRNA catabolic process
u	0097526	cellular_component	spliceosomal tri-snRNP complex
u	1903241	biological_process	U2-type prespliceosome assembly
u	1990904	cellular_component	ribonucleoprotein complex
U	0000244	biological_process	spliceosomal tri-snRNP complex assembly
U	0000245	biological_process	spliceosomal complex assembly
U	0000387	biological_process	spliceosomal snRNP assembly
U	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
U	0000398	biological_process	mRNA splicing, via spliceosome
U	0004843	molecular_function	cysteine-type deubiquitinase activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005681	cellular_component	spliceosomal complex
U	0006397	biological_process	mRNA processing
U	0008270	molecular_function	zinc ion binding
U	0008380	biological_process	RNA splicing
U	0016579	biological_process	protein deubiquitination
U	0016787	molecular_function	hydrolase activity
U	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
U	0046872	molecular_function	metal ion binding
U	0051301	biological_process	cell division
V	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
V	0000398	biological_process	mRNA splicing, via spliceosome
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005681	cellular_component	spliceosomal complex
V	0005689	cellular_component	U12-type spliceosomal complex
V	0006397	biological_process	mRNA processing
V	0008270	molecular_function	zinc ion binding
V	0008380	biological_process	RNA splicing
V	0046872	molecular_function	metal ion binding
W	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
W	0000398	biological_process	mRNA splicing, via spliceosome
W	0003676	molecular_function	nucleic acid binding
W	0003723	molecular_function	RNA binding
W	0003729	molecular_function	mRNA binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005681	cellular_component	spliceosomal complex
W	0005689	cellular_component	U12-type spliceosomal complex
W	0005730	cellular_component	nucleolus
W	0006397	biological_process	mRNA processing
W	0008380	biological_process	RNA splicing
W	0017069	molecular_function	snRNA binding
W	1990904	cellular_component	ribonucleoprotein complex
X	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
X	0000398	biological_process	mRNA splicing, via spliceosome
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005681	cellular_component	spliceosomal complex
X	0005689	cellular_component	U12-type spliceosomal complex
X	0006397	biological_process	mRNA processing
X	0008380	biological_process	RNA splicing
Y	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
Y	0000398	biological_process	mRNA splicing, via spliceosome
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005681	cellular_component	spliceosomal complex
Y	0005689	cellular_component	U12-type spliceosomal complex
Y	0005829	cellular_component	cytosol
Y	0006397	biological_process	mRNA processing
Y	0008270	molecular_function	zinc ion binding
Y	0008380	biological_process	RNA splicing
Y	0046872	molecular_function	metal ion binding
Z	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
Z	0000398	biological_process	mRNA splicing, via spliceosome
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005689	cellular_component	U12-type spliceosomal complex
Z	0006915	biological_process	apoptotic process
Z	0008380	biological_process	RNA splicing
Z	0051384	biological_process	response to glucocorticoid

Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmI

Chain	Residue	Details
I	VAL547-ILE555

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHaDIKpdNILV

Chain	Residue	Details
Q	ILE811-VAL823

---

site_id	PS00436
Number of Residues	12
Details	PEROXIDASE_2 Peroxidases active site signature. TVrvARVmWHPS

Chain	Residue	Details
M	THR323-SER334

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LGTTcyDrSWRLWDL

Chain	Residue	Details
M	LEU338-LEU352
M	ILE422-LEU436
F	LEU81-VAL95
F	LEU124-SER138
F	VAL167-ILE181
F	ILE208-LEU222
F	ILE300-THR314

---

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CedknVPYvfVrSKqaLG

Chain	Residue	Details
O	CYS73-GLY90

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	131
Details	Domain: {"description":"MPN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	491
Details	Region: {"description":"Reverse transcriptase homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	273
Details	Region: {"description":"Linker"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	13
Details	Region: {"description":"Important for branch point selection","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	171
Details	Region: {"description":"Restriction endonuclease homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	34
Details	Region: {"description":"Required for interaction with EFTUD2 and SNRNP200","evidences":[{"source":"PubMed","id":"17317632","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N6,N6-dimethyllysine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	282
Details	Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	183
Details	Domain: {"description":"Helicase ATP-binding 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	237
Details	Domain: {"description":"Helicase C-terminal 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	305
Details	Domain: {"description":"SEC63 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	175
Details	Domain: {"description":"Helicase ATP-binding 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	208
Details	Domain: {"description":"Helicase C-terminal 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	312
Details	Domain: {"description":"SEC63 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	53
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	133
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	3
Details	Motif: {"description":"DEIH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	3
Details	Motif: {"description":"DEVH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23045696","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4F93","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"F1LNJ2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q6P4T2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	16
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	78
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	86
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	79
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	78
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	78
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	79
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	63
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	32
Details	Repeat: {"description":"HAT 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	26
Details	Repeat: {"description":"HAT 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	31
Details	Repeat: {"description":"HAT 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	32
Details	Repeat: {"description":"HAT 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	32
Details	Repeat: {"description":"HAT 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	32
Details	Repeat: {"description":"HAT 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	32
Details	Repeat: {"description":"HAT 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	32
Details	Repeat: {"description":"HAT 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	205
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI49
Number of Residues	148
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI50
Number of Residues	28
Details	Motif: {"description":"Q motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00552","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI51
Number of Residues	3
Details	Motif: {"description":"DEAD box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI52
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI53
Number of Residues	648
Details	Domain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI54
Number of Residues	79
Details	Region: {"description":"Sufficient for interaction with CLNS1A","evidences":[{"source":"PubMed","id":"11747828","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI55
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI56
Number of Residues	14
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI57
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Matallanas D.","Cooper W.N.","Kolch W."]}},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI58
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI59
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI60
Number of Residues	34
Details	Coiled coil: {"evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI61
Number of Residues	13
Details	Motif: {"description":"Nuclear localization signal (NLS)","evidences":[{"source":"PubMed","id":"12444105","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI62
Number of Residues	1
Details	Site: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI63
Number of Residues	3
Details	Site: {"description":"Interaction with U4 snRNA and U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI64
Number of Residues	1
Details	Site: {"description":"Interaction with U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI65
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI66
Number of Residues	12
Details	Region: {"description":"Interaction with U4 snRNA and U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21784869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI67
Number of Residues	32
Details	Region: {"description":"Important for U4 snRNA-binding","evidences":[{"source":"PubMed","id":"10545122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI68
Number of Residues	2
Details	Site: {"description":"Interaction with U4 snRNA and U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21784869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI69
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D0T1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI70
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; by NAT10","evidences":[{"source":"PubMed","id":"31722219","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI71
Number of Residues	28
Details	Zinc finger: {"description":"C3H1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00723","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI72
Number of Residues	78
Details	Domain: {"description":"RRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI73
Number of Residues	27
Details	Zinc finger: {"description":"CHHC U11-48K-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01141","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI74
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01141","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI75
Number of Residues	330
Details	Domain: {"description":"USP"}

Chain

Residue

Details

---

site_id	SWS_FT_FI76
Number of Residues	97
Details	Zinc finger: {"description":"UBP-type; degenerate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00502","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI77
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00502","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI78
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI79
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI80
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI81
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q5RKH1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---